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News from NCI

  • Schematic of TLR4-C/EBPdelta- FBXW7alpha feedback loops in inflammatory signaling, showing, with arrows, how these proteins interact with each other
    A tumor suppressor is identified as an inhibitor of inflammatory pathways
    NCI News Note

    (Posted: 04/09/2013) - Scientists at NCI have found that a protein, FBXW7, which acts as a tumor suppressor, is also important for the reduction in strength of inflammatory pathways. It has long been recognized that a complex interaction exists between cancer causing mechanisms and inflammation.

  • 3 investigators from NCI’s Pediatric Oncology Branch, standing side by side in the atrium of the D.C. convention center at the AACR 2013 annual meeting, with the AACR banner in the background. From left to right, Crystal Mackall, M.D., Daniel Lee, M.D., and Alan Wayne, M.D.
    Cancer immunotherapy in children: How does it differ from approaches in adults?
    NCI Perspective

    (Posted: 04/08/2013) - More often than not, cancer immunotherapies that work in adults are used in modified ways in children. Seldom are new therapies developed just for children, primarily because of the small number of pediatric patients relative to the adult cancer patient population. Depicted are members of NCI’s Pediatric Oncology Branch. From left: Drs. Crystal Mackall, Daniel Lee, and Alan Wayne

  • Mitochondrial chaperones may represent novel targets for developing anti-cancer drugs
    NCI News Note

    (Posted: 04/01/2013) - Scientists at NCI have found that a mitochondrial chaperone protein, TRAP1, may act indirectly as a tumor suppressor as well as a novel target for developing anti-cancer drugs. Chaperone proteins, such as TRAP1, help other proteins adapt to stress, but scientists are coming to appreciate that they have other functions as well, such as, in this case, affecting tumor development.

  • The potential of large studies for building genetic risk prediction models
    NCI News Note

    (Posted: 03/04/2013) - NCI scientists have developed a new paradigm to assess hereditary risk prediction in common diseases, such as prostate cancer. This genetic risk prediction concept is based on polygenic analysis—the study of a group of common DNA sequences, known as single nucleotide polymorphisms (SNPs), each of which contributes a very small amount to overall disease risk, but has a strong effect when grouped together.

  • NIH study finds increases in risk of certain leukemias related to treatment
    NCI Press Release

    (Posted: 02/14/2013) - A new study describes the pattern of risk for chemotherapy-related acute myeloid leukemia among adult cancer survivors over the past three decades who have previously been treated with chemotherapy for other cancers. These patterns coincide with major shifts in treatment practices. In particular, the study found that the risk of treatment-related AML among patients treated for non-Hodgkin lymphoma has increased steadily during the last few decades.

  • NCI study finds that sunitinib benefits patients with renal cell carcinoma
    NCI News Note

    (Posted: 02/07/2013) - Findings from clinical trial patients with metastatic renal cell carcinoma, a common kidney cancer, show they did not have accelerated tumor growth after treatment with sunitinib, in contrast to some study results in animals.

  •  Translucent plastic bag containing bevacizumab and other chemo drugs dripping through I.V. port
    Bevacizumab significantly improves survival for patients with recurrent and metastatic cervical cancer
    NCI Press Release

    (Posted: 02/07/2013, Updated: 06/02/2013) - Patients with advanced, recurrent, or persistent cervical cancer that was not curable with standard treatment who received the drug bevacizumab (Avastin) lived 3.7 months longer than patients who did not receive the drug, according to an analysis of a large, randomized clinical trial.

  • NIH scientists identify molecular link between metabolism and breast cancer
    NCI Press Release

    (Posted: 02/05/2013) - A protein associated with conditions of metabolic imbalance, such as diabetes and obesity, may play a role in the development of aggressive forms of breast cancer, according to new findings by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, and their colleagues.

  • DNA breaks early in replication process associated with B cell cancers
    NCI News Note

    (Posted: 01/24/2013) - Research by scientists at the NCI has identified a new class of DNA sites in cells that break early in the replication process. They found that these break sites correlate with damage often seen in B cell cancers, such as diffuse large B cell lymphoma.

  • Map of U.S. showing percentages of girls who have received HPV vaccine, with states in yellow showing low rates and states in purple having high rates.
    Report to the Nation shows U.S. cancer death rates continue to drop; Special feature highlights trends in HPV-associated cancers and HPV vaccination coverage levels
    NCI Press Release

    (Posted: 01/07/2013) - The Annual Report to the Nation on the Status of Cancer, 1975–2009, shows that overall cancer death rates continued to decline in the United States among both men and women, among all major racial and ethnic groups, and for all of the most common cancer sites, including lung, colon and rectum, female breast, and prostate.
    View the article in Spanish

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  • Posted: August 13, 2012
  • Updated: August 13, 2012