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News from NCI
  • Increased risk of chronic lymphocytic leukemia in Chernobyl cleanup workers
    NCI News Note

    (Posted: 11/08/2012) - A new study found a significantly elevated risk for chronic lymphocytic leukemia among workers who were engaged in recovery and clean-up activities following the Chernobyl power plant accident in 1986.

  • This bar graph displays the years of life gained when participants met various percentages of  HHS guidelines for physical activity. 50% = 1.8 years.  100% = 3.4 years. 200% = 4.2 years. 300% = 4.5 years.
    NIH study finds leisure-time physical activity extends life expectancy as much as 4.5 years
    NCI Press Release

    (Posted: 11/06/2012) - Leisure-time physical activity is associated with longer life expectancy, even at relatively low levels of activity and regardless of body weight, according to a study by a team of researchers led by the NCI. The study, which found that people who engaged in leisure-time physical activity had life expectancy gains of as much as 4.5 years, appeared Nov. 6, 2012, in PLoS Medicine.
    View the article in Spanish

  • NIH study uncovers new mechanism of action for class of chemotherapy drugs
    NCI Press Release

    (Posted: 11/01/2012) - NIH researchers have discovered a significant new mechanism of action for a class of chemotherapy drugs known as poly (ADP-ribose) polymerase inhibitors, or PARP inhibitors. They have also identified differences in the toxic capabilities of three drugs in this class which are currently being tested in clinical trials. Prior to this study, PARP inhibitors were thought to work primarily by blocking PARP enzyme activity, thus preventing the repair of DNA damage and ultimately causing cell death.

  • Gene variant linked to lung cancer risk
    NCI News Note

    (Posted: 10/09/2012) - A variation of the gene NFKB1, called rs4648127, is associated with an estimated 44 percent reduction in lung cancer risk. When this information, derived from samples obtained as part of a large NCI-sponsored prevention clinical trial, was compared with data on a different sample collection from NCI’s genome-wide association studies (GWAS), lung cancer risk was still estimated to be lower, but only by 21 percent.

  • HIV infection connected to rising anal cancer rates in men in the U.S.
    NCI News Note

    (Posted: 10/05/2012) - Human immunodeficiency virus (HIV) infection contributes substantially to the epidemic of anal cancer in men, but not women in the United States, according to new research from NCI. Chart shows overall incidence rates of anal cancers in general population with dashed line showing those with HIV infection.

  • Black and white microscope image of human lymphocyte, which appears as a white ball with tendrils branching off from the surface.
    NIH study uncovers likely role of major cancer protein
    NIH Press Release

    (Posted: 09/27/2012) - Scientists may have discovered why a protein called MYC can provoke a variety of cancers. Like many proteins associated with cancer, MYC helps regulate cell growth. A study carried out by researchers at NIH and colleagues found that, unlike many other cell growth regulators, MYC does not turn genes on or off, but instead boosts the expression of genes that are already turned on.

  • Microscopic view of breast cancer cells with cell nuclei stained blue and dots responding to overproduction of the HER2 protein lit up in bright red
    Study reveals genomic similarities between breast and ovarian cancers
    NIH Press Release

    (Posted: 09/24/2012) - A new study from The Cancer Genome Atlas captured a complete view of genomic alterations in breast cancer and classified them into four intrinsic subtypes, one of which shares many genetic features with high-grade serous ovarian cancer. Depicted are breast cancer cells with the HER2 protein, which can trigger cell growth responses, lit up in bright red. (Photo credit: NIST)

  • Head shot color photo of NCI director Harold Varmus
    What Impedes Cancer Research?: NCI Director Harold Varmus to address National Press Club
    Press Opportunity

    (Posted: 09/21/2012) - The barriers that impede greater and faster progress against cancer include the inherent biological properties of tumors; the difficulties of developing new ways to prevent, diagnose and treat cancers; and economic and social factors that slow the nation’s cancer research efforts

  • Kidneys and adrenal glands in cartoon illustration
    Rare cancers yield potential source of tumor growth
    NIH Press Release

    (Posted: 09/17/2012) - Researchers at the National Institutes of Health have discovered a genetic mutation that appears to increase production of red blood cells in tumors. The discovery, based on analysis of tissue from rare endocrine tumors, may help clarify how some tumors generate a new blood supply to sustain their growth, the researchers explained.

  • Box of colored bars, depicting genes identified by TCGA for association with methylation (blue) or mutation (purple) in squamous lung cancer
    TCGA discovers potential therapeutic targets for lung squamous cell carcinoma
    NCI Press Release

    (Posted: 09/10/2012) - After sequencing the genomes of nearly 200 patients, researchers from The Cancer Genome Atlas initiative have identified potential therapeutic targets in lung squamous cell carcinoma, the second most common form of lung cancer. In the image above, squamous lung cancer subtypes are grouped into four columns. The horizontal rows depict genes identified by TCGA and how they differ by subtype.

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