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  • Cervical Cancer: paradigms at home and abroad
    NCI Perspective

    (Posted: 06/02/2013) - NCI funded a clinical trial that will have an impact on the treatment of late-stage cervical cancer, and also supported a screening trial in India using a network of community outreach workers offering low tech-screening by direct visualization of the cervix coated with dilute acetic acid (vinegar), a process known as VIA. Image depicts cervical cancer microvessel density which increases lethality of the cancer.

  • NIH scientists find link between allergic and autoimmune diseases in mouse study
    NCI Press Release

    (Posted: 06/02/2013) - Scientists at the National Institutes of Health, and their colleagues, have discovered that a gene called BACH2 may play a central role in the development of diverse allergic and autoimmune diseases, such as multiple sclerosis, asthma, Crohn's disease, celiac disease, and type-1 diabetes.

  • NIH researchers conduct first genomic survey of human skin fungal diversity; Location on the body surface determines fungal composition with the greatest diversity on feet
    NIH Press Release

    (Posted: 05/22/2013) - Fungal infections of the skin affect 29 million people in the United States. In the first study of human fungal skin diversity, National Institutes of Health researchers sequenced the DNA of fungi that thrive at different skin sites of healthy adults to define the normal populations across the skin topography and to provide a framework for investigating fungal skin conditions.

  • Black and white CT scan from 25 year-old patient with newly diagnosed metastatic ASPS; left scan is cross-section of the chest at the start of the trial showing significant tumor mass in white, and right scan is post-treatment, with significant tumor shrinkage, shown as smaller areas in white.
    Experimental drug beneficial in NIH trial to treat a rare sarcoma
    NCI Press Release

    (Posted: 05/02/2013) - Patients with advanced alveolar soft part sarcoma (ASPS), a rare cancer, achieved some control of their disease using an experimental anti-cancer drug called cediranib. The results from this largest clinical trial on ASPS to date were published in the Journal of Clinical Oncology

  • Study establishes basis for genomic classification of endometrial cancers; proper categorization is important for choosing the best treatment
    NCI Press Release

    (Posted: 05/01/2013) - A comprehensive genomic analysis of nearly 400 endometrial tumors suggests that certain molecular characteristics – such as the frequency of mutations – could complement current pathology methods and help distinguish between principal types of endometrial tumors, as well as provide insights into potential treatment strategies.

  • TCGA researchers identify potential drug targets, markers for leukemia risk; New study reveals relatively few mutations in AML genomes
    NCI Press Release

    (Posted: 05/01/2013) - Investigators for The Cancer Genome Atlas (TCGA) Research Network have detailed and broadly classified the genomic alterations that frequently underlie the development of acute myeloid leukemia (AML), a deadly cancer of the blood and bone marrow. Their work paints a picture of a cancer marked by relatively few mutations compared to other types of cancer occurring in adults.

  • A drug target that stimulates development of healthy stem cells
    NCI News Note

    (Posted: 04/17/2013) - Scientists have overcome a major impediment to the development of effective stem cell therapies by studying mice that lack CD47, a protein found on the surface of both healthy and cancer cells. They discovered that cells obtained from the lungs of CD47-deficient mice, but not from ordinary mice that have the CD47 gene, multiplied in a culture dish and spontaneously converted into stem cells

  • Testing lung cancer drugs and therapies in mice
    NCI News Note

    (Posted: 04/15/2013) - National Cancer Institute (NCI) investigators have designed a genetically engineered mouse for use in the study of human lung squamous cell carcinoma (SCC). SCC is a type of non-small cell lung carcinoma, one of the most common types of lung cancer, with a five-year survival rate of about 15 percent.

  • Two NCI investigators reviewing CT scan on computer screen with 26 year old male patient, shown at far right.  Cross-sectional scan on right side of screen shows 15 cm tumor mass in mediastinum and scan on left shows complete remission 7 months later with no tumor evident.
    NIH trial shows promising results in treating a lymphoma in young people
    NCI Press Release

    (Posted: 04/10/2013) - Patients with a type of cancer known as primary mediastinal B-cell lymphoma who received infusions of chemotherapy, but who did not have radiation therapy to an area of the thorax known as the mediastinum, had excellent outcomes, according to clinical trial results.

  • Schematic of TLR4-C/EBPdelta- FBXW7alpha feedback loops in inflammatory signaling, showing, with arrows, how these proteins interact with each other
    A tumor suppressor is identified as an inhibitor of inflammatory pathways
    NCI News Note

    (Posted: 04/09/2013) - Scientists at NCI have found that a protein, FBXW7, which acts as a tumor suppressor, is also important for the reduction in strength of inflammatory pathways. It has long been recognized that a complex interaction exists between cancer causing mechanisms and inflammation.

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  • Posted: August 13, 2012
  • Updated: August 13, 2012