NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
- amrubicin hydrochloride
The hydrochloride salt of a third-generation synthetic 9-amino-anthracycline with antineoplastic activity. Amrubicin intercalates into DNA and inhibits the activity of topoisomerase II, resulting in inhibition of DNA replication, and RNA and protein synthesis, followed by cell growth inhibition and cell death. This agent has demonstrated a higher level of anti-tumor activity than conventional anthracycline drugs without exhibiting any indication of the cumulative cardiac toxicity common to this class of compounds. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonym: Amirubicin Hydrochloride Foreign brand name: Calsed Abbreviation: AMR Chemical structure:
- (+)-(7S,9S)-9-acetyl-9-amino-7-[(2-deoxy-β-D-erythro-pentopyranosyl)oxy]- 6,11-dihydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride
- 5,12-naphthacenedione, 9-acetyl-9-amino-7-[(2-deoxy-β-D-erythro- pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxy-, (7S,9S)-