NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
A murine monoclonal antibody with two antigen-recognition sites: one for CD3, an antigen expressed on mature T cells, and one for HER-2-neu, a tumor-associated antigen that promotes tumor growth. Ertumaxomab attaches to CD3-expressing T cells and HER-2-neu-expressing tumor cells, selectively cross-linking tumor and immunologic cells which results in the recruitment of cytotoxic T cells to the T cell/tumor cell aggregate. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms: anti-CD3 x anti-HER-2-neu bispecific monoclonal antibody
MOAB anti-CD3 x anti-HER-2-neu
Abbreviation: CD3-HER2neu MOAB