NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

buserelin
A synthetic analog of gonadotropin-releasing hormone (GnRH). Buserelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Prolonged administration of buserelin results in sustained inhibition of gonadotropin production, suppression of testicular and ovarian steroidogenesis, and reduced levels of circulating gonadotropin and gonadal steroids. Buserelin is more potent that GnRH. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonyms:buserelin acetate
busereline
US brand name:Etilamide
Foreign brand names:Bigonist
Profact
Profact Depot
Receptal
Suprecur
Suprefact
Suprefact Depot
Suprefact Flakon
Abbreviation:BSRL
Code names:HOE 766
ICI 123215
S74-6766
Chemical structures:6-[O-(1,1-dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-10-deglycinamide luteinizing hormone-releasing factor (pig)
D-ser (bu(t))(6) pro(9) NEt LHRH Acetate