NCI Drug Dictionary

  • Resize font
  • Print
  • Email
  • Facebook
  • Twitter
  • Google+
  • Pinterest

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

penicillamine
A beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, penicillamine chelates with heavy metals and increases their urinary excretion. Possessing antineoplastic properties, penicillamine induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Depamine
D-mercaptovaline
D-Penicillamine
US brand names:Cuprenil
Cuprimine
Depen
Perdolat
Sufortan
Foreign brand names:Atamir
Cupripen
Distamine
Kelatin
Mercaptyl
Metalcaptase
Pendramine
Trolovol
Chemical structures:3-mercapto-D-valine
alpha-amino-beta-methyl-beta-mercaptobutyric acid
beta,beta-dimethylcysteine
beta-thiovaline