NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

A semisynthetic derivative of the nucleoside-like antineoplastic antibiotic spicamycin, originally isolated from the bacterium Streptomyces alanosinicus. KRN 5500 inhibits protein synthesis by interfering with endoplasmic reticulum and Golgi apparatus functions. This agent also induces cell differentiation and caspase-dependent apoptosis. Check for active clinical trials using this agent. (NCI Thesaurus)
Chemical structure:(6-[4-deoxy-4-(2E, 4E)-tetradecadienoylglycyl] amino-L-glycero - beta-L-mannoheptopyranosyl] amino-9H-purine)