NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

vadimezan
A fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity. Vadimezan induces the cytokines tumor necrosis alpha (TNF-alpha), serotonin and nitric oxide, resulting in hemorrhagic necrosis and a decrease in angiogenesis. This agent also stimulates the anti-tumor activity of tumor-associated macrophages. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonym:Dimethyloxoxanthene Acetic Acid
Abbreviations:5,6-MexXAA
DMXAA
Code names:AS1404
ASA404
Chemical structure:5,6-Dimethylxanthenone-4-Acetic Acid