NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
A fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity. Vadimezan induces the cytokines tumor necrosis alpha (TNF-alpha), serotonin and nitric oxide, resulting in hemorrhagic necrosis and a decrease in angiogenesis. This agent also stimulates the anti-tumor activity of tumor-associated macrophages. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonym: Dimethyloxoxanthene Acetic Acid Abbreviation: 5,6-MexXAA
Code name: AS1404
Chemical structure: 5,6-Dimethylxanthenone-4-Acetic Acid