NCI Dictionary of Cancer Terms

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The NCI Dictionary of Cancer Terms features 7,777 terms related to cancer and medicine.

Browse the dictionary by selecting a letter of the alphabet or by entering a cancer-related word or phrase in the search box.

AG014699
A substance being studied in the treatment of breast cancers caused by mutations (changes) in the BRCA1 and BRCA2 genes. It is also being studied in the treatment of other types of cancer. It blocks an enzyme involved in many functions of the cell, including the repair of DNA damage. DNA damage may be caused by normal cell actions, UV light, some anticancer drugs, and radiation used to treat cancer. AG014699 may cause cancer cells to die. It is a type of poly(ADP-ribose) polymerase inhibitor. Also called PARP-1 inhibitor AG014699.