NCI Dictionary of Cancer Terms
The NCI Dictionary of Cancer Terms features 7,940 terms related to cancer and medicine.
- Bloom syndrome
- listen (… SIN-drome)
- A rare, inherited disorder marked by height that is shorter than average, a narrow face with redness and a rash, a high-pitched voice, and fertility problems. Patients with this disorder have an increased risk of cancer, especially leukemia and osteosarcoma (bone cancer). Bloom syndrome is caused by changes in a protein that normally helps cells make copies of the DNA. Changes in this protein cause many breaks, rearrangements, and other mutations in the DNA. It is a type of autosomal recessive genetic disease. Also called Bloom-Torre-Machacek syndrome.