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Established Investigator Award in Cancer Prevention and Control (K05)

Please note: NCI no longer accepts applications for the K05. The Funding Opportunity Announcement expires on January 8, 2015, and will not be reissued.

The NCI Established Investigator Award in Cancer Prevention and Control (K05) provides established investigators protected time to:

  1. Conduct research in cancer prevention, control, behavioral sciences and population sciences, and
  2. Mentor junior investigators.

For more complete information, reference the Program Announcement and/or contact the program staff.

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Applicant Eligibility

At the time of the award, the candidate must be:

  • a citizen of the United States,
  • or a noncitizen national,
  • or must have been lawfully admitted for permanent residence and possess an Alien Registration Receipt Card (1-151 or 1-551) or some other verification of legal admission as a permanent resident.

Citizenship or green card is not needed to apply. Citizenship or green card is needed at the time of award issuance.

Foreign Nationals with Student VisasNot eligible for this award
Degree/Academic AppointmentEstablished Investigators (Full Professor or equivalent); at the time of application and award, the candidate must have independent R01 research funding or its equivalent
Effort Level/ CommitmentThe candidate must commit up to 3 calendar months (25%) full-time professional effort to the research and mentoring proposed in this award.
Duration of Award3 - 5 years; the K05 Award is renewable one time

Special NCI Eligibility Requirements

The candidate must be the Principal Investigator (PI) of an R01, or R01-like, peer-reviewed cancer-focused research grant at the time of application and during the award to be eligible for the K05 Award.

For the NCI K05, R01-like research funding includes peer-reviewed research grants from other federal sources and private foundations. The award duration must be for at least 3 years with a minimum of $150,000 direct costs per year. Grants under a no-cost extension do not qualify.

The PI is expected to maintain such research grant support during the K05 project period. If the awardee loses peer-reviewed independent research support during the K05 Award period, the awardee must document efforts to replace this support and demonstrate that he or she continues to meet all other requirements of the K05 Award.


Financial Support
SalaryUp to $50K/year + fringe benefits
Research Development Support for Mentees: Tuition/Fees, Supplies/Equipment, Travel, Technical Personnel and Statistical ServicesUp to $25K/year
F&A Costs/ Indirect Costs8%
Ancillary Personnel Support: Salary for Secretarial and Administrative Assistance, etc.Not allowed

How to Apply

For assistance with application submission, please see the Frequently Asked Questions and/or contact eRA Commons Help Desk/ contact Center.


Application Receipt Dates and Review Schedule
Receipt CycleReceipt Date: New ApplicationReceipt Date: Renewal, Resubmission ApplicationInitial ReviewCouncil ReviewEarliest Possible Start Date*
1February 12March 12June/JulySeptember/
2June 12July 12October/NovemberJanuary/
3October 12November 12February/MarchMay/JuneJuly

* Start dates are determined by the availability of NCI funds and may not occur until well after the earliest possible start date.

Applications are due by 5 pm local time. 

When a standard submission date falls on a weekend or Federal holiday, the application deadline is automatically extended to the next business day.

Review and Selection Process

The Center for Scientific Review (CSR) and the National Cancer Institute (NCI) review applications for completeness and for conformance to all eligibility requirements and special provisions and requirements. Incomplete applications will be returned to the applicant without further consideration.

Subcommittee J, convened by the Division of Extramural Activities of the NCI, evaluates applications according to the review criteria listed in the Program Announcement. Before an award is made, the National Cancer Advisory Board (NCAB) conducts a second level of review and ensures that an application meets the broad program needs and priorities of the NCI and the National Cancer Program.

For review criteria for the K05 grant mechanism, see the Review Criteria section of the Program Announcement.

Find an overview of the grant process


NCI Staff Contacts

For additional information regarding policies and/or guidance in preparing an application for the K05 Award, contact:

For information regarding fiscal and/or budget issues, contact:

For information regarding review issues, contact:

  • Referral Officer
    Division of Extramural Activities
    Phone: 240-276-6390

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  • Updated: December 5, 2014