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The Pathway to Independence Award (K99/R00)

  • Updated: 02/04/2014

Introduction

The objective of the NIH Pathway to Independence Award (K99/R00) is to help outstanding postdoctoral researchers complete needed mentored training and transition in a timely manner to independent tenure-track or equivalent faculty positions.

NCI accepts K99/R00 applications that propose laboratory-based cancer research. NCI encourages those involved in non-laboratory based research to consider applying for the NCI K07 (Cancer Prevention, Control, Behavioral Sciences, and Population Sciences Career Development Award), or the NCI K22 (NCI Transition Career Development Award) mechanisms.

Reference the program announcement or contact the program staff for more information.

Applicant Eligibility

Citizens, Foreign Nationals and Student VisasU.S. citizens and non-U.S. citizen/permanent residents are eligible to apply for this award. For applications submitted on behalf of non-U.S. citizens with temporary U.S. visas, visa status during each phase of the K99/R00 award must allow the PD/PI to conduct the proposed research at the applicant institution. For the K99 phase of the award, the applicant institution is responsible for determining and documenting, in the K99 application, that the candidate’s visa will allow him or her to remain in the U.S. long enough to complete the K99 phase of the award. For the R00 phase of the award, the U.S institution at which the R00 phase of the award will be conducted is responsible for determining and documenting, in the R00 application, that the PD/PI’s visa will allow the PD/PI to remain in the U.S. for the duration of the R00 award.
Geographic LocationK99/R00 recipients must reside in and work at U.S.-based institutions for the duration of the award
Career Stage
  • Postdoctoral and Clinical Fellows
  • Applicants must have no more than 4 years of postdoctoral research experience (i.e., employment in a research position since completing the requirements for the doctorate) at the time of the initial or the subsequent resubmission or revision application. If an applicant achieves independence (i.e., any faculty or non-mentored research position) before a K99 award is made, neither the K99 award, nor the R00 award, will be issued.
CommitmentCandidate must commit a minimum 9.0 calendar months (75%) full-time professional effort to the K99/R00 career development award
Duration of Award
  • K99 phase: 1-2 years
  • R00 phase: 1-3 years
  • Up to 5 years of total support

Financial Support

K99 Phase
SalaryUp to $100K a year + fringe benefits
Research Development Support: Research and Career Development ActivitiesUp to $30K a year
F&A Costs/Indirect Costs8%
Ancillary Personnel Support; Salary for Mentors, Secretarial and Administrative Assistance, etc.Not Allowed
R00 Phase
Salary Research Development Support: Research and Career Development Activities F&A/ Indirect CostsUp to $249K a year
Ancillary Personnel Support; Salary for Mentors, Secretarial and Administrative Assistance, etc.Not Allowed
Salary for Postdoctoral, Technician, Lab Manager SupportAllowed

Program Announcement & Related Links

Program Announcementhttp://grants.nih.gov/grants/guide/pa-files/PA-14-042.html
Current List of K99/R00 AwardsFunded active K99
Link to Main Peer Review Group NCI-Ihttps://public.era.nih.gov/pubroster/jsp/proster.jsp?CID=102233
Application Form and Detailshttp://www.grants.gov/web/grants/applicants/download-application-package.html#download=true&oppNum=PA-14-042
Noticeshttp://grants.nih.gov/grants/new_investigators/QsandAs.htm
Transition Info/Formshttp://grants.nih.gov/grants/guide/pa-files/PA-14-042.html#_Section_VI._Award

R00 Transition Application Information

R00 Transition Application Details

http://grants.nih.gov/grants/guide/pa-files/PA-14-042.html#_Section_VI._Award

http://grants.nih.gov/grants/new_investigators/index.htm

http://grants.nih.gov/grants/new_investigators/index.htm#indaward


Citizenship, Foreign Nationals, and Student VisasFor the R00 phase of the award, the U.S institution at which the R00 phase of the award will be conducted is responsible for determining and documenting, in the R00 application, that the PD/PI’s visa will allow the PD/PI to remain in the U.S. for the duration of the R00 award.
Geographic LocationR00 recipients must reside in and work at U.S. based institutions for the duration of the award
Career StageTenure-track full-time position (or equivalent) offered and accepted
Institutional Commitment
  • The R00 Institution must provide protected time (9 calendar months or 75% effort) for the duration of the R00 award
  • The R00 Institution may not require the use of R00 funds to offset a typical start-up package (salary and other)
  • The R00 Institution must provide assurance that the PI’s appointment is not contingent on the transfer of the R00 award to the institution
Duration of AwardR00 phase: Up to 3 years
Transition Application

The independent phase institution should submit an application on behalf of the candidate for the R00 award using the PHS 398 Application no later than 2 months prior to the proposed activation date of the R00 award.


The R00 application must include:

  • A new face page signed by the R00 phase institutional representative
  • A new project description page (the project summary or abstract should be updated to reflect current plans for the R00 phase)
  • Detailed budget pages for a non-modular budget
  • Biographical sketches (PI, collaborators, and consultants)
  • A new Resources page
  • Final Progress Report for the K99 phase
  • An updated research plan (the specific aims should be updated to reflect current plans for the R00 phase and the updated research plan should be briefly described in less than 5 pages)
  • An updated Bibliography & References Cited section
  • A new checklist
  • A letter from the R00 Department or Division Chairman describing the R00 institution’s commitment to the candidate and plans for his/her career development
  • A final evaluation statement by the K99 phase mentor

Human Subjects

If the proposed research involves human subjects, provide:

  • An updated Human Subjects section, including an "Inclusion Enrollment Report"
  • Current IRB approval or expected approval date. Award is not made until final IRB approval is granted.

Vertebrate Animals

If the proposed research involves vertebrate animals, provide:

  • An updated Vertebrate Animals section. IACUC approval is JIT information. Award is not made until final IACUC approval is granted.
Application Due DateAt least two months prior to the proposed activation date of the R00 award