Introduction
The Paul Calabresi Award (K12) is a multi- and transdisciplinary institutional training award supporting the research career development of clinicians only or clinicians and Ph.D. basic scientists to: 1) perform clinical oncology therapeutic research that develops and tests scientific hypotheses based on fundamental and clinical research findings; 2) design and test hypothesis-based, clinical therapeutic protocols and adjunct biological analyses and for clinician candidates to administer all phases (i.e., pilot/phase I, phase II, and phase III) of cancer therapeutic clinical trials; and 3) conduct cancer therapeutic research in team research settings in which basic and clinical scientists collaborate and interact to expedite the translation of basic research discoveries into patient-oriented therapeutic cancer research.
For more complete information, reference the program announcement 1 and/or contact the program staff.
PI Eligibility
| Citizenship | At the time of the award, the PI must be a citizen or must have been lawfully admitted to the United States for permanent residence (i.e., in possession of a currently valid Alien Registration Receipt Card (1-151 or 1-551), or other legal verification of such status |
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| Foreign Nationals and Student Visas | Not eligible for this award |
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| Career Stage | Established Investigators (Associate and Full Professors) |
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| Commitment | Recommended: 2 - 10% |
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| Duration of Award | Up to 5 yrs of support
The K12 is renewable |
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K12 Scored Review Criteria
| Career Development Program Plan and Environment | - Does the proposed program clearly outline a plan to recruit and develop well-qualified new investigators in an area relevant to the objectives of the FOA?
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| Program PI | - Do the PD/PI and Research Administrator (if applicable), have the experience to develop, direct and administer the proposed program?
- Does the leadership team bring complementary and integrated expertise to the program?
- Is there evidence that an appropriate level of effort will be devoted by the program leadership to ensure program objectives?
- Are the research qualifications, scientific stature, previous leadership and mentoring experience, and track records appropriate for the proposed career development program?
- Are the PD(s)/PI(s) currently engaged in research relevant to the scientific area of the proposed program?
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| Mentors | - Do the mentors have expertise and experience, as well as track records of past mentoring and training?
- Are the quality and extent of the mentor’s roles in providing guidance and scientific advice to the scholars acceptable?
- Are the mentors currently engaged in relevant research?
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| Candidates/Scholars | - What is the quality of plans to identify, recruit, and select candidates, with a commitment to research relevant to the mission of the FOA, and the potential to develop as independent researchers?
- Is there an appropriate plan for the content, the phasing, and the proposed duration of the career development plan for achieving scientific independence for the prospective candidates?
- How useful is the research plan as a vehicle for ensuring research training for all Scholars as described in the career development plan?
- What is the likelihood that the career development plan will contribute significantly to the scientific development of the scholars?
- Does the program include a plan to recruit, identify, and select candidates with a commitment to research relevant to the objectives of the FOA?
- Does the program description include a plan to recruit a diverse group of scholars locally and nationally?
- Does the plan for selection of the scholars include all of the eligibility criteria stated in the FOA?
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| Training Record | - Is there evidence of a successful past training record of the PD/PI and mentors, including the success of former scholars in seeking independent support and establishing productive scientific careers?
- Are the evaluation plan and timeline adequate for assessing the effectiveness (process and outcome) of the program in achieving its goals and objectives?
- For Renewal applications: Has the program been adequately evaluated and has the level of success been satisfactory? Do the results of the evaluation document a continued need for support for this program? Is the approach for the next project period responsive to the results of the program’s evaluation?
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Other Information
| Institutional Commitment | - The strength of the institution's commitment to the Program, especially with regard to ensuring that each scholar will have protected time to commit 75 percent of a full-time professional effort to research career development.
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| Integration with Other Programs | - The degree to which this program is effectively integrated with other existing training and career development programs to avoid duplication and achieve maximum complementarily.
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| Responsible Conduct of Research | - Appropriateness and adequacy of training in the responsible conduct of research
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| MD: PhD Ratio | 2:1 |
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Scholar Eligibility
| Citizenship | At the time of the award the candidate must be a citizen of the United States, or must have been lawfully admitted for permanent residence and possess an Alien Registration Receipt Card (1-151 or 1-551) or some other verification of legal admission as a permanent resident |
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| Foreign Nationals and Student Visas | Not eligible for this award |
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| Career Stage | - Candidates or trainees must be physicians holding the M.D. or D.O. degrees, Pham.D. recipients, or be nurses with a Ph.D. degree; and must have completed the necessary clinical training (i.e., completed residency and are board eligible) to engage in clinical oncology research.
- All basic science candidates must have doctoral-level degrees (e.g., Ph.D.) or the equivalent, a minimum of 2 years of postdoctoral research training, and a total basic research experience that is clearly preparatory (e.g., experience with animal models or preclinical research) for devoting a career to human therapeutic cancer research.
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| Commitment | Candidate must commit a minimum 9.0 calendar months. (75%) full-time professional effort to research and career development |
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| VA Appointments | Candidates who have U.S. Veterans’ Administration (VA) appointments may not consider part of the VA effort toward satisfying the “full time” requirement at the applicant institution |
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| Duration of Award | 2 to 4 yrs of support |
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K12 Program Allowable Costs
| Direct Cost limits: | - Applications supporting only clinician scholars must not exceed $750,000 for direct costs per year
- Applications supporting both clinician scholars and basic science scholars must not exceed $1,050,000 for direct costs per year.
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| Other Costs: | - Leadership, management, coordination, and evaluation of the program in accordance to the percent effort commitment to the program.
- Partial salary plus fringe benefits for a dedicated administrator
- Minimal costs for advertising and recruitment
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| Ancillary Personnel Support | Salary for mentors, secretarial and administrative assistance, etc., not Allowed |
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| F & A costs/Indirect costs | 8% |
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Financial Support for each K12 Fellow
| Salary | Up to $100K/ yr + fringe benefits |
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| Research Development Support; i.e. tuition/fees, supplies/ equipment, travel, and statistical services | Up to $30K/ yr |
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Program Announcement & Related Links
