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Cancer Snapshots: Disease Focused and Other Snapshots

  • Posted: 11/05/2014

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A Snapshot of Adolescent and Young Adult Cancers

Cancers Affecting Adolescents and Young Adults (AYAs)

An estimated 69,212 adolescents and young adults (AYAs) ages 15–39 were diagnosed with cancer in 2011.1 This is about six times the number of cases diagnosed in children ages 0–14. The incidence of specific cancer types varies dramatically across the AYA age continuum. For example, leukemia, lymphoma, testicular cancer (germ cell tumors), and thyroid cancer are the most common cancer types in younger AYAs (15–24 years old). By ages 25–39, breast cancer and melanoma comprise a growing share of cancers among AYAs.2

Bar graphs depicting the number of observed cases of the Common Types of Cancer Affecting AYAs for Age at Diagnosis 15-19, 20-24, 25-29, 30-34, and 35-39. Leukemia and lymphoma are the most common types of cancers at ages at diagnosis 15-19, 20-24, and 25-29. By ages at diagnosis 30-34, thyroid and breast cancers are the most common types of cancer.

Source:  SEER 18, 2007-2011, ages 15-39

Incidence, Mortality, and Survival

In 2011, cancer was the leading cause of disease-related death in the AYA population.3 Among AYAs, only accidents, suicide, and homicide claimed more lives than cancer.

Incidence rates of cancers in AYAs vary by race and ethnicity. Rates of both cancer incidence and 5-year survival are highest among white AYAs. Asian/Pacific Islander AYAs have the lowest cancer incidence rates. African Americans have intermediate incidence rates and the lowest 5-year survival rates. Despite concerns that improvements in mortality were seen in childhood cancers but not AYA populations, recent analyses suggest that mortality rates among adolescents with cancer decreased in a manner similar to that observed among children aged <15 years since 2000.4
 

Line graph depicting 5-Year Survival of AYAs with Cancer (Survival Percentage) for White Non-Hispanic, Hispanic, Asian/Pacific Islander, American Indian/Alaska Native, and African American for 1-5 Years after diagnosis.  Analysis was based on any death from any cancer site in both sexes and all races, ages 15-39. At 5 years after diagnosis, percent survival is 86% for Whites, 79% for Hispanics and Asian/Pacific Islanders, and 72% for African Americans.

Data source: SEER 13 Areas, 1992-2010

Examples of NCI Activities Relevant to AYA Cancers

Selected Advances in AYA Cancers Research

  • Cancer death rates for both children and adolescents younger than 20 years declined from 2000 to 2010, particularly for those diagnosed with acute lymphoblastic leukemia, acute myeloid leukemia, non-Hodgkin lymphoma, Hodgkin lymphoma, neuroblastoma, central nervous system cancers, and gonadal cancers.  The rates of decline in cancer mortality in 15- to19-year-olds were equal to or greater that the rates of decline for for younger children. Published May 2014. [PubMed Abstract]
  • Selected Adolescent and Young Adult Health Outcomes and Patient Experiences (AYA HOPE) Study advances include:
    • A survey of AYA cancer patients found that perceptions of their cancer care depended on how satisfied they were with the communication of information, side-effect management, and expediency and flexibility of treatments.  Financial and health insurance struggles contributed to dissatisfaction with care.  Published January 2014.  [PubMed Abstract]
    • AYA cancer survivors reported that a lack of health insurance and financial concerns were the biggest barriers to receiving medical care in the first few years after diagnosis.  Published January 2014.  [PubMed Abstract]
    • In AYA cancer survivors, the likelihood of having health insurance decreased with increasing time since diagnosis.  AYAs who were of an older age at the time of diagnosis and had lower levels of education were most likely to lack insurance. Published June 2014. [PubMed Abstract]
  • Compared with adults without a history of cancer, AYA cancer survivors have excess medical expenditures greater than $3,000 per person and excess annual productivity losses greater than $2,000 per person. [PubMed Abstract]

Additional Resources for AYA Cancers

NCI Adolescents and Young Adults with Cancer Portal
Information about cancer in adolescents and young adults: treatment, clinical trials, support options, research, and other topics from the National Cancer Institute.

Cancer in Young People
Information about the most common types of cancer seen in adolescents and young adults.

Cancer in Children and Adolescents
A fact sheet about statistics, types, causes, and treatment of cancers in children and adolescents in the United States.

Focus Under Forty
A series of educational modules developed by American Society of Clinical Oncology and LIVESTRONG Foundation, with input from the NCI. 

NCI’s AYA YouTube Playlist
Three videos where cancer researchers, advocates, and cancer survivors discuss AYA cancers and issues relevant to AYA cancers.

Adolescents and Young Adults with Cancer: Reports, Research, and Literature
Reports and research projects that address the special challenges facing AYAs with cancer and provide details about incidence, outcomes, and survival for this population.


  • 1 An estimated projection calculated by the Surveillance, Epidemiology and End Results (SEER) Program using SEER 18, 2007-2011.
  • 2 Data from the SEER Program.
  • 3 Total U.S. deaths in 2011, ages 15–39, from the SEER Program and the National Center for Health Statistics.
  • 4 Smith, M.A., Altekruse, S.F., Adamson, P.C., Reaman, G.H. and N.L. Seibel. Declining childhood and adolescent cancer mortality. Cancer. 2014;120(16):2497-2506.  [PubMed Abstract]