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Alternate Title
Basic Trial Information
Trial Description
     Purpose
     Eligibility
     Treatment/Intervention
Trial Contact Information
Registry Information

Alternate Title

Phase II Study of Perifosine in Patients With Advanced Soft Tissue Sarcoma

Basic Trial Information

Phase	Type	Status	Age	Sponsor	Protocol IDs
Phase II	Treatment	Closed	18 and over	NCI	MAYO-MC0276 NCI-5972, NCT00064324, 5972

Trial Description

Purpose:

Drugs used in chemotherapy such as perifosine use different ways to stop tumor cells from dividing so they stop growing or die.

Phase II trial to study the effectiveness of perifosine in treating patients who have advanced soft tissue sarcoma.

Eligibility:

• At least 18 years old
• Measurable disease
• More than 4 weeks since biological therapy, chemotherapy, or radiation therapy
• No more than two previous chemotherapy regimens for metastatic sarcoma
• For more information about the eligibility criteria for this trial, refer to the Health Professional version.

Final eligibility for a clinical trial is determined by the health professionals conducting the trial.

Treatment/Intervention:

Patients will receive perifosine by mouth every 6 hours on day 1 and once a day thereafter. Treatment may continue for as long as benefit is shown. Patients will be evaluated every 3 months for 5 years.

Important:

For more details about this trial, refer to the Health Professional version of the trial summary.

If you are interested in participating in a clinical trial, contact your doctor for a referral or call a trial contact person listed below. You may see the same contact person listed at more than one site, however, if you call the number listed you can ask to speak to the study coordinator or person involved with the specific trial you are interested in. If you have questions about cancer or clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). General information about clinical trials, including risks, benefits, and costs, can be found on NCI's Web site.

Trial Contact Information

Trial Lead Organizations

Mayo Clinic Cancer Center

Howard Bailey, MD, Protocol chair		Ph: 608-263-8624; 800-622-8922 Email: hhb@medicine.wisc.edu

Registry Information
Official Title		A Phase II Study Of Perifosine In Soft Tissue Sarcoma
Trial Start Date		2003-06-13
Registered in ClinicalTrials.gov		NCT00064324
Date Submitted to PDQ		2003-06-03
Information Last Verified		2004-04-19
NCI Grant/Contract Number		P30-CA15083

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