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Alternate Title
Basic Trial Information
Trial Description
     Purpose
     Eligibility
     Treatment/Intervention
Trial Contact Information
Registry Information

Alternate Title

Phase II Study of Bortezomib in Patients With Recurrent or Refractory Extensive-Stage Small Cell Lung Cancer Previously Treated With Platinum-Based Therapy

Basic Trial Information

Phase	Type	Status	Age	Sponsor	Protocol IDs
Phase II	Treatment	Completed	18 and over	NCI	SWOG-S0327 S0327, NCT00068289

Trial Description

Purpose:

Bortezomib may stop the growth of tumor cells by blocking the enzymes necessary for their growth.

Phase II trial to study the effectiveness of bortezomib in treating patients who have recurrent or refractory extensive-stage small cell lung cancer that was previously treated with platinum -based chemotherapy (such as cisplatin, carboplatin, or oxaliplatin).

Eligibility:

• At least 18 years old
• Measurable disease
• At least 3 weeks since chemotherapy or radiation therapy
• At least 2 weeks since surgery
• For more information about the eligibility criteria for this trial, refer to the Health Professional version.

Final eligibility for a clinical trial is determined by the health professionals conducting the trial.

Treatment/Intervention:

Patients will receive an infusion of bortezomib twice a week for 2 weeks. Treatment may be repeated every 3 weeks for as long as benefit is shown. Patients will be evaluated every 6 months for 2 years.

Important:

For more details about this trial, refer to the Health Professional version of the trial summary.

If you are interested in participating in a clinical trial, contact your doctor for a referral or call a trial contact person listed below. You may see the same contact person listed at more than one site, however, if you call the number listed you can ask to speak to the study coordinator or person involved with the specific trial you are interested in. If you have questions about cancer or clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). General information about clinical trials, including risks, benefits, and costs, can be found on NCI's Web site.

Trial Contact Information

Trial Lead Organizations

Southwest Oncology Group

Primo Lara, MD, Study coordinator		Ph: 916-734-3771
Angela Davies, MD, Study coordinator		Ph: 916-734-3771

Registry Information
Official Title		A Phase II Trial of PS-341 (NSC-681239) in Patients with Platinum-Treated Extensive Stage Small Cell Lung Cancer
Trial Start Date		2003-09-01
Registered in ClinicalTrials.gov		NCT00068289
Date Submitted to PDQ		2003-07-10
Information Last Verified		2004-08-16
NCI Grant/Contract Number		CA32102

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