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Alternate Title
Basic Trial Information
Trial Description
     Purpose
     Eligibility
     Treatment/Intervention
Trial Contact Information
Registry Information

Alternate Title

Phase II Study of Fludeoxyglucose F18 Positron Emission Tomography for Pre- and Post-treatment Assessment in Patients With Locally Advanced Non-Small Cell Lung Cancer

Basic Trial Information

Phase	Type	Status	Age	Sponsor	Protocol IDs
Phase II	Biomarker/Laboratory analysis, Diagnostic	Closed	18 and over	NCI	ACRIN-6668 RTOG-0235, NCT00083083

Trial Description

Purpose:

Imaging procedures, such as fludeoxyglucose F18 positron emission tomography (¹⁸FDG-PET), may improve the ability to detect disease progression and help doctors predict a patient's response to treatment and plan more effective treatment.

This phase II trial is studying how well ¹⁸FDG-PET imaging works in detecting disease progression and determining response to treatment in patients who are undergoing chemoradiotherapy for locally advanced non-small cell lung cancer.

Eligibility:

Eligibility criteria include the following:

• At least 18 years old
• No brain metastases
• No previous radiation therapy to the chest
• For more information about the eligibility criteria for this trial, refer to the Health Professional version.

Final eligibility for a clinical trial is determined by the health professionals conducting the trial.

Treatment/Intervention:

Patients will receive an infusion of fludeoxyglucose F 18 followed by a whole-body PET scan before and approximately 14 weeks after undergoing chemoradiotherapy. Patients will be evaluated every 3 months for 2 years and every 6 months for at least 1 year.

Important:

For more details about this trial, refer to the Health Professional version of the trial summary.

If you are interested in participating in a clinical trial, contact your doctor for a referral or call a trial contact person listed below. You may see the same contact person listed at more than one site, however, if you call the number listed you can ask to speak to the study coordinator or person involved with the specific trial you are interested in. If you have questions about cancer or clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). General information about clinical trials, including risks, benefits, and costs, can be found on NCI's Web site.

Trial Contact Information

Trial Lead Organizations

American College of Radiology Imaging Network

Mitchell Machtay, MD, Protocol chair		Ph: 215-955-6706; 800-533-3669 Email: mitchell.machtay@jeffersonhospital.org

Radiation Therapy Oncology Group

Mitchell Machtay, MD, Protocol chair		Ph: 215-955-6706; 800-533-3669 Email: mitchell.machtay@jeffersonhospital.org

Registry Information
Official Title		Positron Emission Tomography Pre- and Post-treatment Assessment For Locally Advanced Non-Small Cell Lung Carcinoma
Trial Start Date		2005-03-01
Trial Completion Date		2006-06-01 (estimated)
Registered in ClinicalTrials.gov		NCT00083083
Date Submitted to PDQ		2004-03-17
Information Last Verified		2007-10-29
NCI Grant/Contract Number		CA080098

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