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Alternate Title
Basic Trial Information
Trial Description
     Purpose
     Eligibility
     Treatment/Intervention
Trial Contact Information
Registry Information

Alternate Title

Randomized Study of Heparin Versus Minocycline Hydrochloride and Edetate Calcium Disodium (M-EDTA) for the Prevention of Catheter-Related Infections and Occlusions in Patients at High Risk for a Catheter-Related Infection

Basic Trial Information

Phase	Type	Status	Age	Sponsor	Protocol IDs
No phase specified	Supportive care	Completed	Any age	NCI	MDA-ID-93004 MDA ID93-004, NCT00378781

Trial Description

Purpose:

Heparin or M-EDTA may prevent catheter -related infections and blockages in patients at high risk for a catheter-related infection. It is not yet known whether heparin is more effective than M-EDTA in preventing catheter-related infections and blockages in patients at high risk for a catheter-related infection.

This randomized clinical trial is studying heparin to see how well it works compared with M-EDTA in preventing catheter-related infections and blockages in patients at high risk for a catheter-related infection.

Eligibility:

Eligibility criteria include the following:

• Any age
• No more than 10 days since placement of a central venous catheter
• Central venous catheter is working
• No catheter-related blockage or infection
• For more information about the eligibility criteria for this trial, refer to the Health Professional version.

Final eligibility for a clinical trial is determined by the health professionals conducting the trial.

Treatment/Intervention:

Patients will be randomly assigned (have an equal chance of being placed) to one of two treatment groups.

Patients in group one will have their central venous catheter flushed with M-EDTA once a day. Treatment may continue for up to 3 months.

Patients in group two will have their central venous catheter flushed with heparin once a day. Treatment may continue for up to 3 months.

Important:

For more details about this trial, refer to the Health Professional version of the trial summary.

If you are interested in participating in a clinical trial, contact your doctor for a referral or call a trial contact person listed below. You may see the same contact person listed at more than one site, however, if you call the number listed you can ask to speak to the study coordinator or person involved with the specific trial you are interested in. If you have questions about cancer or clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). General information about clinical trials, including risks, benefits, and costs, can be found on NCI's Web site.

Trial Contact Information

Trial Lead Organizations

M. D. Anderson Cancer Center at University of Texas

Jorge Cortes, MD, Principal investigator		Ph: 713-794-5783; 800-392-1611 Email: jcortes@mdanderson.org

Registry Information
Official Title		Prospective, Randomized Trial Comparing Heparin and Minocycline-EDTA Flush for the Prevention of Catheter-Related Infections and Occlusions
Trial Completion Date		2007-12-28
Registered in ClinicalTrials.gov		NCT00378781
Date Submitted to PDQ		2006-07-31
Information Last Verified		2007-09-30
NCI Grant/Contract Number		CA16672

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