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Alternate Title
Basic Trial Information
Trial Description
     Purpose
     Eligibility
     Treatment/Intervention
Trial Contact Information
Registry Information

Alternate Title

Phase II Study of Unrelated Bone Marrow Transplantation with Cyclophosphamide and Total-Body Irradiation in Patients With Hematologic Malignancies/Disorders

Basic Trial Information

Phase	Type	Status	Age	Sponsor	Protocol IDs
Phase II	Treatment	Closed	17 to 60	Other	TUHSC-2803 NCI-V96-0950, NCT00002809

Trial Description

Purpose:

Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage cancer cells. Combining chemotherapy and radiation therapy together with bone marrow transplant may allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells.

This phase II trial is studying how well giving bone marrow transplant from an unrelated donor together with cyclophosphamide and total-body irradiation works in treating patients with hematologic cancer.

Eligibility:

Eligibility criteria include the following:

• 17-60 years old
• No CNS cancer
• For more information about the eligibility criteria for this trial, refer to the Health Professional version.

Final eligibility for a clinical trial is determined by the health professionals conducting the trial.

Treatment/Intervention:

Patients will receive high-dose cyclophosphamide and total-body irradiation for 4 days followed by infusion of donor bone marrow plus filgrastim. Some patients may also receive sargramostim. Patients will receive tacrolimus and methotrexate to prevent graft-versus-host disease. Patients will receive follow-up evaluations at approximately 3 months, 6 months, 1 year, and once a year thereafter.

Important:

For more details about this trial, refer to the Health Professional version of the trial summary.

If you are interested in participating in a clinical trial, contact your doctor for a referral or call a trial contact person listed below. You may see the same contact person listed at more than one site, however, if you call the number listed you can ask to speak to the study coordinator or person involved with the specific trial you are interested in. If you have questions about cancer or clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). General information about clinical trials, including risks, benefits, and costs, can be found on NCI's Web site.

Trial Contact Information

Trial Lead Organizations

Fox Chase Cancer Center CCOP Research Base

Kenneth Mangan, MD, FACP, Protocol chair		Ph: 215-214-3129 Email: mangank@tuhs.temple.edu

Registry Information
Official Title		Unrelated Bone Marrow Transplantation With Cyclophosphamide and Total Body Irradiation For Hematologic Malignancies and Bone Marrow Failure States
Trial Start Date		1996-08-02
Registered in ClinicalTrials.gov		NCT00002809
Date Submitted to PDQ		1996-08-02
Information Last Verified		2005-08-20

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