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Alternate Title
Basic Trial Information
Trial Description
     Purpose
     Eligibility
     Treatment/Intervention
Trial Contact Information
Registry Information

Alternate Title

Phase III Randomized Study of Bleomycin vs Doxycycline vs Talc for Malignant Pleural Effusions (Summary Last Modified 04/2000)

Basic Trial Information

Phase	Type	Status	Age	Sponsor	Protocol IDs
Phase III	Supportive care, Treatment	Completed	18 and over	NCI	E-8592 NCCTG-942853, NCI-P96-0076, NCT00002872

Trial Description

Purpose:

Some drugs such as bleomycin or doxycycline, or other compounds like talc, may help to control fluid in the chest caused by cancer. It is not yet known if bleomycin, doxycycline, or talc is more effective in treating patients with malignant pleural effusions.

Randomized phase III trial to compare the effectiveness of bleomycin, doxycycline, or talc in treating patients with malignant pleural effusions.

Eligibility:

• At least 18 years old
• No previous bleomycin
• For more information about the eligibility criteria for this trial, refer to the Health Professional version.

Final eligibility for a clinical trial is determined by the health professionals conducting the trial.

Treatment/Intervention:

Patients will undergo placement of a catheter. Patients will be randomized to receive treatment with either bleomycin, doxycycline, or talc. Treatment may be repeated 3 days later. Patients will receive follow-up evaluations once a month.

Important:

For more details about this trial, refer to the Health Professional version of the trial summary.

If you are interested in participating in a clinical trial, contact your doctor for a referral or call a trial contact person listed below. You may see the same contact person listed at more than one site, however, if you call the number listed you can ask to speak to the study coordinator or person involved with the specific trial you are interested in. If you have questions about cancer or clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). General information about clinical trials, including risks, benefits, and costs, can be found on NCI's Web site.

Trial Contact Information

Trial Lead Organizations

Eastern Cooperative Oncology Group

John Ruckdeschel, MD, Protocol chair(Contact information may not be current)		Ph: 813-979-7265; 888-663-3488 Email: ruckdeschel@moffitt.usf.edu

North Central Cancer Treatment Group

Randolph Marks, MD, Protocol chair		Ph: 507-284-2511

Registry Information
Official Title		A PROSPECTIVE RANDOMIZED TRIAL OF BLEOMYCIN VS. DOXYCYCLINE VS. TALC FOR THE INTRAPLEURAL TREATMENT OF MALIGNANT PLEURAL EFFUSIONS
Trial Start Date		1996-11-06
Registered in ClinicalTrials.gov		NCT00002872
Date Submitted to PDQ		1996-11-06
Information Last Verified		2009-01-30

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