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Alternate Title
Basic Trial Information
Trial Description
     Purpose
     Eligibility
     Treatment/Intervention
Trial Contact Information
Related Information
Registry Information

Alternate Title

Genetic, Clinical, and Epidemiological Study of Individuals and Families at High Risk of Cancer

Basic Trial Information

Phase	Type	Status	Age	Sponsor	Protocol IDs
No phase specified	Biomarker/Laboratory analysis, Genetics, Natural history/Epidemiology	Active	1 month to 95 years	NCI	NCI-78-C-0039 NCT00004007

Special Category: NIH Clinical Center trial, NCI Web site featured trial

Trial Description

Purpose:

Studying individuals and families at high risk for cancer may help to identify other persons at risk and identify cancer genes.

This clinical trial is studying genetic and environmental factors related to cancer risk in individuals and families at high risk for cancer.

Eligibility:

Eligibility criteria include the following:

• 1 month to 95 years old
• Known or suspected cancer risk factors, such as family or personal history of cancer or environmental or genetic factors known to increase risk of cancer
• For more information about the eligibility criteria for this trial, refer to the Health Professional version.

Final eligibility for a clinical trial is determined by the health professionals conducting the trial.

Treatment/Intervention:

One family member will complete a family history questionnaire to verify the diagnosis and create a family pedigree. Individuals and families will undergo a physical evaluation and have blood samples drawn for testing. Some patients may undergo additional diagnostic studies and examinations. A family participating in the study may undergo genetic testing. Genetic counseling will be offered to all individuals who undergo genetic testing. Families will be evaluated every 1-2 years. Some individuals and families will be evaluated more frequently.

Important:

For more details about this trial, refer to the Health Professional version of the trial summary.

If you are interested in participating in a clinical trial, contact your doctor for a referral or call a trial contact person listed below. You may see the same contact person listed at more than one site, however, if you call the number listed you can ask to speak to the study coordinator or person involved with the specific trial you are interested in. If you have questions about cancer or clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). General information about clinical trials, including risks, benefits, and costs, can be found on NCI's Web site.

Trial Contact Information

Trial Lead Organizations

NCI - Center for Cancer Research

Margaret Tucker, MD, Protocol chair		Ph: 301-496-4375

U.S.A.
Maryland
	Bethesda
	NCI - Division of Cancer Epidemiology and Genetics
		Genetic Epidemiology Branch Referral Nurse	Ph:  800-518-8474
	Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office
		Patient Recruitment	Ph:  888-NCI-1937

Related Information

Featured trial article

Registry Information
Official Title		Clinical, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Cancer
Trial Start Date		1978-01-01
Trial Completion Date		2020-12-31 (estimated)
Registered in ClinicalTrials.gov		NCT00004007
Date Submitted to PDQ		1999-07-08
Information Last Verified		2009-06-07

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