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Alternate Title
Basic Trial Information
Trial Description
     Purpose
     Eligibility
     Treatment/Intervention
Trial Contact Information
Registry Information

Alternate Title

Phase II Pilot Study of Temozolomide in Patients With Leptomeningeal Metastases From a Solid Tumor or Lymphoma

Basic Trial Information

Phase	Type	Status	Age	Sponsor	Protocol IDs
Phase II	Treatment	Completed	Over 18	NCI	DMS-9812 NCI-G00-1782, NCT00005812

Trial Description

Purpose:

Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die.

Phase II trial to study the effectiveness of temozolomide in treating patients who have leptomeningeal metastases from a solid tumor or lymphoma.

Eligibility:

• At least 19 years old
• For more information about the eligibility criteria for this trial, refer to the Health Professional version.

Final eligibility for a clinical trial is determined by the health professionals conducting the trial.

Treatment/Intervention:

Patients will receive temozolomide by mouth daily for 6 weeks. Treatment may continue every 10 weeks for as long as benefit is shown. Quality of life will be assessed before treatment, once a week for 4 weeks, and then once a month thereafter.

Important:

For more details about this trial, refer to the Health Professional version of the trial summary.

If you are interested in participating in a clinical trial, contact your doctor for a referral or call a trial contact person listed below. You may see the same contact person listed at more than one site, however, if you call the number listed you can ask to speak to the study coordinator or person involved with the specific trial you are interested in. If you have questions about cancer or clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). General information about clinical trials, including risks, benefits, and costs, can be found on NCI's Web site.

Trial Contact Information

Trial Lead Organizations

Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center

Thomas Davis, MD, Protocol chair		Ph: 603-650-8626; 800-639-6918

Registry Information
Official Title		A Pilot Phase II Trial of Temozolomide in Leptomeningeal Metastases
Trial Start Date		2000-01-03
Registered in ClinicalTrials.gov		NCT00005812
Date Submitted to PDQ		2000-03-24
Information Last Verified		2003-11-20
NCI Grant/Contract Number		CA23108

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