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Alternate Title
Basic Trial Information
Trial Description
     Purpose
     Eligibility
     Treatment/Intervention
Trial Contact Information
Registry Information

Alternate Title

Phase I Study of Photodynamic Therapy With Silicon Phthalocyanine 4 in Patients With Cutaneous Malignancies

Basic Trial Information

Phase	Type	Status	Age	Sponsor	Protocol IDs
Phase I	Treatment	Completed	18 and over	NCI	CWRU-1Y97 NCI-T99-0007, NCT00023790, T99-0007, CASE-1Y97

Trial Description

Purpose:

Photodynamic therapy uses light and drugs that make cancer cells more sensitive to light to kill tumor cells. This may be effective treatment for skin cancer and cancer that is metastatic to the skin.

Phase I trial to study the effectiveness of photodynamic therapy in treating patients who have either squamous cell or basal cell carcinoma of the skin or solid tumors metastatic to the skin.

Eligibility:

Eligibility criteria include the following:

• At least 18 years old
• Measurable disease
• No tumors of the eyelids
• At least 4 weeks since biological therapy or chemotherapy
• More than 4 weeks since radiation therapy
• At least 6 months since photodynamic therapy
• For more information about the eligibility criteria for this trial, refer to the Health Professional version.

Final eligibility for a clinical trial is determined by the health professionals conducting the trial.

Treatment/Intervention:

Patients will receive a 2-hour infusion of the photosensitizing drug on day 1 followed by light therapy directed at the skin lesions on day 2. Treatment may be repeated after 6 weeks. Patients will be evaluated at 6-8 weeks and every 3 months thereafter.

Important:

For more details about this trial, refer to the Health Professional version of the trial summary.

If you are interested in participating in a clinical trial, contact your doctor for a referral or call a trial contact person listed below. You may see the same contact person listed at more than one site, however, if you call the number listed you can ask to speak to the study coordinator or person involved with the specific trial you are interested in. If you have questions about cancer or clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). General information about clinical trials, including risks, benefits, and costs, can be found on NCI's Web site.

Trial Contact Information

Trial Lead Organizations

Ireland Cancer Center at University Hospitals/Case Medical Center

Scot Remick, MD, Protocol chair		Ph: 216-844-5412

Registry Information
Official Title		Phase I Trial of PC 4-PDT (NSC 676418) for Cutaneous Malignancies
Trial Start Date		2001-08-24
Trial Completion Date		2006-02-08
Registered in ClinicalTrials.gov		NCT00023790
Date Submitted to PDQ		2001-07-06
Information Last Verified		2006-01-19
NCI Grant/Contract Number		CA43703, CA62502

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