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Alternate Title
Basic Trial Information
Trial Description
     Purpose
     Eligibility
     Treatment/Intervention
Trial Contact Information
Registry Information

Alternate Title

Phase II Study of Sequential Neoadjuvant Docetaxel, Cisplatin, and Radiotherapy Followed By Surgery in Patients With Operable Stage IIIB Non-Small Cell Lung Cancer

Basic Trial Information

Phase	Type	Status	Age	Sponsor	Protocol IDs
Phase II	Treatment	Closed	18 to 75	Other	SWS-SAKK-16/01 EU-20137, NCT00030810

Trial Description

Purpose:

Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high energy x-rays to damage tumor cells. Combining chemotherapy with radiation therapy before surgery may shrink the tumor so that it can be removed during surgery.

Phase II trial to study the effectiveness of combination chemotherapy followed by radiation therapy before surgery in treating patients who have stage IIIB non-small cell lung cancer.

Eligibility:

Eligibility criteria include the following:

• 18-75 years old
• No metastatic cancer
• No previous radiation therapy to the chest
• For more information about the eligibility criteria for this trial, refer to the Health Professional version.

Final eligibility for a clinical trial is determined by the health professionals conducting the trial.

Treatment/Intervention:

Patients will receive infusions of docetaxel and cisplatin. Treatment may be repeated every 3 weeks for three courses. Beginning 3 weeks after completing chemotherapy, some patients will undergo radiation therapy once or twice a day 5 days a week for 3 weeks. Within 3-4 weeks after completing radiation therapy, patients will undergo surgery to remove the tumor. All patients will be evaluated at 1 month and every 3 months thereafter.

Important:

For more details about this trial, refer to the Health Professional version of the trial summary.

If you are interested in participating in a clinical trial, contact your doctor for a referral or call a trial contact person listed below. You may see the same contact person listed at more than one site, however, if you call the number listed you can ask to speak to the study coordinator or person involved with the specific trial you are interested in. If you have questions about cancer or clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). General information about clinical trials, including risks, benefits, and costs, can be found on NCI's Web site.

Trial Contact Information

Trial Lead Organizations

Swiss Group for Clinical Cancer Research

Roger Stupp, MD, Protocol chair		Ph: 41-21-314-0156 Email: roger.stupp@chuv.ch

Registry Information
Official Title		Preoperative Chemoradiotherapy In Non-Small Cell Lung Cancer (NSCLC) Patients With Operable Stage IIIB Disease: A Prospective Phase II Trial
Trial Start Date		2001-09-05
Registered in ClinicalTrials.gov		NCT00030810
Date Submitted to PDQ		2001-12-11
Information Last Verified		2006-10-01

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