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Alternate Title
Basic Trial Information
Trial Description
     Purpose
     Eligibility
     Treatment/Intervention
Trial Contact Information
Related Information
Registry Information

Alternate Title

Diagnostic Study of Contrast-Enhanced Magnetic Resonance Imaging and Correlative Molecular Studies in Women With Locally Advanced Breast Cancer Who Are Receiving Neoadjuvant Chemotherapy

Basic Trial Information

Phase	Type	Status	Age	Sponsor	Protocol IDs
No phase specified	Diagnostic	Active	18 and over	NCI	CALGB-150007 NCT00033397

Trial Description

Purpose:

Comparing results of diagnostic procedures performed before, during, and after chemotherapy may help doctors predict a patient's response to treatment and help plan the most effective treatment.

Diagnostic trial to study magnetic resonance imaging (MRI) and biomarkers in women who are receiving chemotherapy before surgery for locally advanced breast cancer.

Eligibility:

Eligibility criteria include the following:

• At least 18 years old
• No distant metastases
• Must be enrolled in clinical trial ACRIN-6657/CALGB-150012
• No chemotherapy or radiation therapy to the other breast
• At least 4 weeks since tamoxifen or raloxifene
• For more information about the eligibility criteria for this trial, refer to the Health Professional version.

Final eligibility for a clinical trial is determined by the health professionals conducting the trial.

Treatment/Intervention:

Patients will undergo MRI of the breast, biopsy, and blood collections before, during and after chemotherapy. They will also undergo mammography with or without ultrasound before and after chemotherapy. Patients will be evaluated every 6 months for 5 years and once a year for 10 years.

Important:

For more details about this trial, refer to the Health Professional version of the trial summary.

If you are interested in participating in a clinical trial, contact your doctor for a referral or call a trial contact person listed below. You may see the same contact person listed at more than one site, however, if you call the number listed you can ask to speak to the study coordinator or person involved with the specific trial you are interested in. If you have questions about cancer or clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). General information about clinical trials, including risks, benefits, and costs, can be found on NCI's Web site.

Trial Contact Information

Trial Lead Organizations

Cancer and Leukemia Group B

Laura Esserman, MD, MBA, Protocol chair		Ph: 415-885-7691; 800-888-8664

U.S.A.
California
	San Francisco
	UCSF Helen Diller Family Comprehensive Cancer Center
		Clinical Trials Office - UCSF Helen Diller Family Comprehensive Cancer Center	Ph:  877-827-3222
District of Columbia
	Washington
	Lombardi Comprehensive Cancer Center at Georgetown University Medical Center
		Clinical Trials Office - Lombardi Comprehensive Cancer Center	Ph:  202-444-0381
Illinois
	Chicago
	University of Chicago Cancer Research Center
		Clinical Trials Office - University of Chicago Cancer Research Center	Ph:  773-834-7424
Minnesota
	Minneapolis
	Masonic Cancer Center at University of Minnesota
		Clinical Trials Office - Masonic Cancer Center at University of Minnesota	Ph:  612-624-2620
North Carolina
	Chapel Hill
	Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
		Clinical Trials Office - Lineberger Comprehensive Cancer Center	Ph:  877-668-0683; 919-966-4432
Texas
	Dallas
	Parkland Memorial Hospital
		Thomas Weatherall, Jr.	Ph:  214-590-5582
	Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
		Clinical Trials Office - Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas	Ph:  866-460-4673; 214-648-7097

Related Information

PDQ® clinical trial CLB-49808
PDQ® clinical trial ACRIN-6657

Registry Information
Official Title		Contrast-Enhanced Breast MRI, MRS, And Correlative Science Studies To Characterize Tumor Response In Patients Undergoing Neoadjuvant Treatment For Locally Advanced Breast Cancer
Trial Start Date		2002-02-01
Trial Completion Date		2005-06-05 (estimated)
Registered in ClinicalTrials.gov		NCT00033397
Date Submitted to PDQ		2002-02-28
Information Last Verified		2009-11-13
NCI Grant/Contract Number		CA31946

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