Alternate Title
Basic Trial Information
Objectives
Entry Criteria
Expected Enrollment
Outcomes
Outline
Trial Contact Information
Registry Information

Alternate Title

Tegafur-Uracil or Observation in Treating Patients With Stage II Colorectal Cancer That Has Been Completely Removed By Surgery

Basic Trial Information

Phase	Type	Status	Age	Sponsor	Protocol IDs
Phase III	Treatment	Active	20 to 80	Other	TMDU-BRI-CC-05-01 NCT00392899

Objectives

Primary

1. Compare the efficacy of adjuvant tegafur-uracil vs observation only in patients with curatively resected stage II colorectal cancer.

Secondary

1. Compare relapse-free and overall survival of patients treated with these regimens.
2. Compare the occurrence of adverse events in patients treated with these regimens.

Entry Criteria

Disease Characteristics:

• Histologically confirmed adenocarcinoma of the colon or rectosigmoid
  • Stage II disease



• Has undergone curative (R0) resection within the past 8 weeks



• No suspicion of hereditary colorectal cancer



• No severe postoperative complications

Prior/Concurrent Therapy:

• See Disease Characteristics
• No prior chemotherapy
• No prior or concurrent radiotherapy
• No concurrent prophylactic growth factors
• No concurrent biologic response modifiers

Patient Characteristics:

• ECOG performance status 0-1
• WBC 3,500-12,000/mm³
• Absolute neutrophil count ≥ 1,500/mm³
• Platelet count ≥ 100,000/mm³
• Hemoglobin ≥ 9.0 g/dL
• Bilirubin ≤ 2.0 mg/dL
• AST and ALT ≤ 100 IU/L
• Creatinine ≤ 1.5 mg/dL
• Not pregnant or nursing
• Able to take oral medications
• Major organ functions are preserved
• No other active malignancy
• None of the following conditions:
  • Uncontrolled diabetes mellitus
  • Uncontrolled hypertension
  • Myocardial infarction or unstable angina pectoris within the past 6 months
  • Liver cirrhosis
  • Interstitial pneumonia
  • Pulmonary fibrosis
  • Severe emphysema
• No psychiatric disease or other condition that would preclude study participation

Expected Enrollment

A total of 2,000 patients will be accrued for this study.

Outcomes

Disease-free survival

Relapse-free survival
Overall survival
Adverse events

Outline

This is a randomized, controlled study. Patients are randomized to 1 of 2 treatment arms.

• Arm I: Patients undergo observation.



• Arm II: Patients receive oral tegafur-uracil on days 1-5. Treatment repeats every 7 days for 1 year in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed periodically for 5 years.

Trial Contact Information

Trial Lead Organizations

Tokyo Medical and Dental University

Kenichi Sugihara, MD, PhD, Protocol chair		Ph: 81-3-5803-5261 Email: k-sugi.srg2@tmd.ac.jp

Japan
	Osaka
	Osaka Red Cross Hospital
		Akiyoshi Kanazawa, MD, PhD	Ph:  81-6-6774-5111
Aichi
	Aichi-gun
	Aichi Medical University
		Toshiaki Nonami, MD	Ph:  81-561-62-3311
	Nagoya
	Aichi Cancer Center
		Takashi Hirai, MD	Ph:  81-52-762-6111
			Email: thirai@aichi-cc.jp
	Ban Buntane Houtokukai Hospital
		Satoshi Arakawa, MD	Ph:  81-52-321-8171
	Nagoya Central Hospital
		Contact Person	Ph:  81-52-452-3165
			Email: soichiro.inoue@jr-central.co.jp
	Nagoya Ekisaikai Hospital
		Hiroshi Kohno, MD	Ph:  81-52-652-7711
	Nagoya Midori Municipal Hospital
		Takuji Fukui, MD, PhD	Ph:  81-52-892-1331
	Nagoya University Hospital
		Yasuhiro Kodera, MD	Ph:  81-52-744-2250
			Email: ykodera@med.nagoya-u.ac.jp
	Nagoya University School of Medicine
		Norihiko Yuasa, MD, PhD	Ph:  81-52-744-2222
	West Medical Center Jouhoku Municipal Hospital
		Takuya Ando, MD, PhD	Ph:  81-52-991-8121
	Nagoya-shi
	Japanese Red Cross Nagoya First Hospital
		Eiji Takeuchi, MD	Ph:  81-52-481-5111
	Nagoya City University Hospital
		Hiromitsu Takeyama, MD	Ph:  81-52-853-8224
	Okazaki
	Aichi Cancer Center at Aichi Hospital
		Contact Person	Ph:  81-564-21-6251
			Email: matsui-ngy@umin.ac.jp
	Toyohashi
	National Hospital Organization Toyohashi Medical Center
		Tooru Ichihara, MD, PhD	Ph:  81-532-62-0301
	Toyohashi Municipal Hospital
		Contact Person	Ph:  81-532-33-6111
			Email: hiramatsu-kazuhiro@toyohashi-mh.jp
	Toyota
	Koseiren Kamo Hospital
		Junichi Kamiya, MD, PhD	Ph:  81-565-31-1511
Akita
	Akita
	Akita Kumiai General Hospital
		Kazuhiko Endo, MD	Ph:  81-18-880-3000
	Noshiro
	Yamamoto Kumiai General Hospital
		Kenichi Oyama, MD	Ph:  81-185-52-3111
	Yokote
	Hiraka General Hospital
		Contact Person	Ph:  81-182-32-5121
			Email: fcl3btkai@yahoo.co.jp
Aomori
	Aomori
	Aomori City Hospital
		Contact Person	Ph:  81-17-734-2171
			Email: htume@actv.ne.jp
Chiba
	Asahi-machi
	Asahi General Hospital
		Nobutaka Tanaka, MD, PhD	Ph:  81-479-63-8111
	Chiba
	Chiba Cancer Center
		Contact Person	Ph:  81-43-264-5431
			Email: ntaki@chiba-cc.jp
	Chiba University
		Contact Person	Ph:  81-43-226-2110
			Email: miyahide@faculty.chiba-u.jp
	Ichihara
	Teikyo University Chiba Medical Center
		Toru Tezuka, MD, PhD	Ph:  81-436-62-1211
	Urayasu-shi
	Juntendo Urayasu Hospital
		Masaki Fukunaga, MD, PhD	Ph:  81-47-353-3111
			Email: masaki-f@juntendo-urayasui.jp
Ehime
	Matsuyama
	Shikoku Cancer Center
		Contact Person	Ph:  81-89-932-1111
			Email: ykubo@shikoku-cc.go.jp
	Niihama
	Sumitomo Besshi Hospital
		Hideyuki Saeki, MD	Ph:  81-397-37-7111
Fukui
	Fukui-shi
	Fukuiken Saiseikai Hospital
		Yoshinori Munemoto, MD	Ph:  81-776-23-1111
	Yoshida-gun
	University of Fukui Hospital
		Akio Yamaguchi, MD, PhD	Ph:  86-776-61-8372
			Email: akio@u-fukui.ac.jp
Fukuoka
	Fukuoka
	National Hospital Organization Kyushu Medical Center
		Tetsuya Kusumoto, MD, PhD
	National Kyushu Cancer Center
		Yasushi Toh, MD, PhD	Ph:  81-92-541-3231
	Fukuoka-shi
	Kyushu University Hospital
		Yoshihiko Maehara, MD, PhD	Ph:  81-92-642-5461
	Kitakyushu
	Kitakyushu Municipal Medical Center
		Yoshitaka Tanabe	Ph:  81-93-541-1831
	Kitakyushu-shi
	University of Occupational and Environmental Health
		Naoki Nagata, MD	Ph:  81-93-691-7441
	Kurume
	Kurume University School of Medicine
		Kazuo Shirouzu, MD, PhD	Ph:  81-942-31-7566
			Email: skazuo@med.kurume-u.ac.jp
	Saint Mary's Hospital
		Satoshi Taniwaki, MD	Ph:  81-942-35-3322
	Tagawa
	Social Insurance Tagawa Hospital
		Takaho Tanaka, MD, PhD	Ph:  81-947-44-0460
Fukushima
	Fukushima-shi
	Fukushima Medical University Hospital
		Shinji Ohki, MD, PhD	Ph:  81-24-547-1259
Gifu
	Gifu
	Matsunami General Hospital
		Kenji Kobayashi, MD	Ph:  81-58-388-0111
	Gifu-shi
	Gifu Municipal Hospital
		Hiroo Oshita, MD	Ph:  81-58-251-1101
	Hashima
	Hashima City Hospital
		Mikio Yasumura, MD, PhD	Ph:  81-58-393-0111
	Ogaki-shi
	Ogaki Municipal Hospital
		Masatoshi Isogai, MD, PhD	Ph:  81-584-81-3341
Gunma
	Maebashi-shi
	Gunma University Graduate School of Medicine
		Hiroyuki Kuwano, MD, PhD	Ph:  81-27-220-8224
			Email: hkuwano@med.gunma-u.ac.jp
	Otashi
	Gunma Cancer Center
		Shinichi Sameshima, MD, PhD	Ph:  81-276-38-0771
Hiroshima
	Fukuyama
	Chugoku Central Hospital of the Mutual Aid Association of Public School Teachers
		Takeshi Kanbara, MD	Ph:  81-84-970-2121
	National Hospital Organization Fukuyama Medical Center
		Hiromi Iwagaki	Ph:  81-84-922-0001
	Hiroshima
	Hiroshima Prefectural Hospital
		Hiroyuki Egi, MD	Ph:  81-82-254-1818
	Hiroshima University Hospital
		Contact Person	Ph:  81-82-257-5222
			Email: mokajima@hiroshima-u.ac.jp
	Kure
	National Hospital Organization Kure Medical Center
		Masato Koseki, MD	Ph:  81-823-22-3111
	Miyoshi
	Miyoshi Central Hospital
		Naokuni Tatsumoto, MD, PhD	Ph:  81-824-65-0101
Hokkaido
	Asahikawa
	Asahikawa Medical College
		Toru Kono, MD	Ph:  81-166-68-2503
	Otaru Ekisaikai Hospital
		Kazuaki Sasaki, MD, PhD	Ph:  81-134-24-0325
	Hakodate
	Hakodate Goryoukaku Hospital
		Akinori Takagane, MD	Ph:  81-138-51-2295
	Otaru-shi
	Hirosaki University, School of Medicine
		Akihiko Murata, MD	Ph:  81-172-39-5079
	Sapporo
	Hokkaido University Graduate School of Medicine
		Satoshi Kondo, MD	Ph:  81-11-706-7714
	Sapporo City General Hospital
		Tatsuyoshi Fukushima, MD	Ph:  81-11-726-2211
	Sapporo Medical University
		Tomohisa Furuhata, MD	Ph:  81-11-611-2111
	Sapporo-shi
	Sapporo-Kosei General Hospital
		Yukifumi Kondo, MD, PhD	Ph:  81-11-261-5331
Hyogo
	Akashi
	Akashi Municipal Hospital
		Youichi Kadotani, MD	Ph:  81-78-912-2323
	Hyogo Cancer Center
		Takeshi Nakamura, MD	Ph:  81-78-929-1151
	Akou
	Ako City Hospital
		Tadashi Yokoyama, MD	Ph:  81-791-43-3222
	Amagasaki
	Hyogo Prefectural Amagasaki Hospital
		Hisashi Shinohara, MD	Ph:  81-6-6482-1521
	Kansai Rosai Hospital
		Syu Okamura	Ph:  81-6-6416-1221
	Himeji
	Himeji Central Hospital
		Yoshinori Munemoto, MD	Ph:  81-79-235-7331
	Himeji St. Mary's Hospital
		Contact Person	Ph:  81-79-265-5111
			Email: yokoyama@himemaria.or.jp
	Itami
	Kinki Central Hospital
		Yoshio Uemura, MD, PhD	Ph:  81-72-781-3712
	Kakogawa
	Kakogawa Municipal Hospital
		Masaaki Mitsutsuji, MD, PhD
	Kobe
	Kobe Medical Center
		Etsuji Shimada, MD	Ph:  81-78-791-0111
	Kobe University Hospital
		Takashi Kamigaki, MD	Ph:  81-78-382-5111
	Kobe West City Hospital
		Masahiko Takeo	Ph:  81-78-576-5251
	Nishi-Kobe Medical Center
		Husao Ikeda, MD	Ph:  81-78-997-2200
	Sano Hospital
		Masahito Kotaka, MD	Ph:  81-78-785-1000
	Shakai Hoken Kobe Central Hospital
		Atsushi Oguro, MD	Ph:  81-78-594-2211
	Kobe-shi
	Kobe City General Hospital
		Noriyuki Okada, MD, PhD	Ph:  81-78-302-4321
	Nishinomiya
	Hyogo College of Medicine
		Contact Person	Ph:  81-798-45-6372
			Email: ntomita@hyo-med.ac.jp
	Sumoto
	Hyogo Prefectural Awaji Hospital
		Masahiko Umeki, MD, PhD	Ph:  81-799-22-1200
	Takarazuka
	Takarazuka Municipal Hospital
		Chang Wooho, MD	Ph:  81-797-87-1161
	Takarazukai
	Higashi Takarazuka Satoh Hospital
		Atsushi Ohkawa, MD	Ph:  81-797-88-2200
	Yamsakicho
	Public Shiso General Hospital
		Shinsuke Satake, MD	Ph:  81-790-62-2410
Ibaraki
	Ibaraki
	National Hospital Organization Mito Medical Center
		Contact Person	Ph:  81-29-240-7711
			Email: koiumim@mito.hosp.go.jp
	Mito
	Mito Saiseikai General Hospital
		Contact Person	Ph:  81-29-254-5151
			Email: takaku@mito-saisei.jp
	Tsuchiura
	Tsuchiura Kyodo General Hospital
		Susumu Hiranuma, MD	Ph:  81-29-823-3111
Ishikawa
	Kahoku-gun
	Kanazawa Medical University
		Shigeki Takashima, MD	Ph:  81-76-286-2211
	Kanazawa
	Kanazawa University Hospital
		Contact Person	Ph:  81-76-265-2362
			Email: hfujita@surg2.m.kanazawa.u.ac.jp
Iwate
	Morioka
	Iwate Medical University Hospital
		Koki Otsuka	Ph:  81-19-651-5111
	Iwate Prefectural Central Hospital
		Contact Person	Ph:  81-19-653-1151
			Email: imochizu@chuo-hp.jp
Kagawa
	Marugame
	Kagawa Rosai Hospital
		Contact Person	Ph:  81-877-23-3111
	Miki
	Kagawa University Hospital
		Keiichi Okano, MD	Ph:  81-87-891-2438
	Takamatsu
	Kagawa Prefectural Central Hospital
		Ichio Suzuka, MD	Ph:  81-87-835-2222
Kagoshima
	Kagoshima
	Nanpuh Hospital
		Toyokuni Suenaga, MD	Ph:  81-99-226-9111
Kanagawa
	Ashigarakami-gun
	Kanagawa Prefectural Ashigawa-kami Hospital
		Yuji Yamamoto, MD, PhD	Ph:  81-465-83-0351
	Chigasaki
	Chigasaki Municipal Hospital
		Contact Person	Ph:  81-467-52-1111
			Email: hosp_keiei@city.chigasaki.kanagawa.jp
	Fujisawa-shi
	Fujisawa City Hospital
		Akira Nakano, MD	Ph:  81-466-25-3111
	Kanagawa
	Kitasato University School of Medicine
		Masahiko Watanabe, MD, PhD	Ph:  81-42-778-8735
	Kawasaki
	Kanto Rosai Hospital
		Masahiro Ishimaru, MD	Ph:  81-44-411-3131 ext. 8101
	Nippon Medical School Musashikosugi Hospital
		Tetsuro Matsunobu, MD, PhD	Ph:  81-44-733-5181
	Saint Marianna University School of Medicine
		Contact Person	Ph:  81-44-977-8111
			Email: s2tsuki@marianna-u.ac.jp
	Sagamihara
	Sagamihara National Hospital
		Yasuhiko Nishiyama, MD	Ph:  81-42-742-8311
	Yokohama
	International Goodwill Hospital
		Noriaki Kameyama, MD, PhD	Ph:  81-45-813-0221
	Kanagawa Cancer Center
		Makoto Akaike, MD	Ph:  81-45-391-5761
	Saiseikai Yokohama City Nanbu Hospital
		Hideyuki Ike, MD, PhD	Ph:  81-45-832-1111
	Showa University Fujigaoka Hospital
		Contact Person	Ph:  81-45-971-1151
			Email: kenjih-ngy@umin.ac.jp
	Social Insurance Yokohama Central Hospital
		Contact Person	Ph:  81-45-641-1921
			Email: mimatsu.kenji@yokochu.jp
	St. Marianna University Yokohama City Seibu Hospital
		Contact Person	Ph:  81-45-366-1111
			Email: a2hanai@marianna-u.ac.jp
	Yokohama City Hospital
		Daiduke Minabe, MD	Ph:  81-45-331-1961
	Yokohama City University Medical Center
		Shoichi Fujii, MD	Ph:  81-45-261-5656
			Email: u0970047@urahp.yokohama-cu.ac.jp
	Yokohama-shi
	Showa University Northern Yokohama Hospital
		Shinei Kudo, MD, PhD	Ph:  81-45-949-7000
	Yokosuka
	Yokosuka Kyosai Hospital
		Kaoru Nagahori, MD, PhD	Ph:  81-46-822-2710
			Email: nagakkr@yahoo.co.jp
Kochi
	Kochi
	Kochi Health Sciences Center
		Akihito Tsuji, MD, PhD	Ph:  81-88-837-3000
	Nankoku
	Kochi Medical School
		Michiya Kobayashi, MD, PhD	Ph:  81-88-880-2202
Kumamoto
	Kumamoto
	Japanese Red Cross Kumamoto Hospital
		Toshihiko Hirata, MD	Ph:  81-96-384-2111
	Kumamoto University Faculty of Medical and Pharmaceutical Sciences
		Naoko Hayashi, MD	Ph:  81-96-373-5212
	Uki
	National Hospital Organization - Kumamotominami Hospital
		Junji Akagi, MD, PhD	Ph:  81-964-32-0826
	Yashiro
	Japan Labor Health and Welfare Organization Kumamoto Rosai Hospital
		Katsuhiko Inoue, MD	Ph:  81-965-33-4151
	Yatsushiro
	Yatsushiro Health Insurance General Hospital
		Masafumi Kuramoto, MD	Ph:  81-965-32-71111
Kyoto
	Higashiyama-ku
	Kyoto First Red Cross Hospital
		Hideaki Kurioka, MD	Ph:  81-75-561-1121
	Kanigyou-ku
	Kyoto Second Red Cross Hospital
		Hitoshi Izumi, MD	Ph:  81-75-231-5171
	Kyoto
	Kyoto Prefectural University of Medicine
		Chohei Sakakura, MD, PhD	Ph:  81-75-251-5527
	Kyoto-Katsura Hospital
		Dai Manaka, PhD	Ph:  81-75-391-5811
	National Hospital Organization - Kyoto Medical Center
		Contact Person	Ph:  81-75-641-9161
			Email: tayamagu@kyotolan.hosp.go.jp
	Nishijin Hospital
		Takuya Miyagaki, MD, PhD	Ph:  81-75-461-8800
	Nantan
	Nantan General Hospital
		Contact Person	Ph:  81-771-42-2510
			Email: uujil015@kha.biglobe.ne.jp
	Sakyo-ku
	Kyoto University Hospital
		Satoshi Nagayama, MD, PhD	Ph:  81-75-751-3227
Mie
	Thu-shi
	Mie University Graduate School of Medicine
		Yashuhiro Inoue, MD, PhD	Ph:  81-59-232-1111 ext. 5645
Miyagi
	Natori-shi
	Miyagi Cancer Center
		Kenichi Shiiba, MD	Ph:  81-22-381-3151
	Sendai
	Sendai Kousei Hospital
		Contact Person	Ph:  81-22-222-6181
			Email: yamauchi@sendai-kousei-hospital.jp
	Sendai Medical Center
		Toshihiro Saito, MD	Ph:  81-22-293-1111
	Tohoku Rosai Hospital
		Hiroaki Musha, MD	Ph:  81-22-275-1111
	Tohoku University Graduate School of Medicine
		Contact Person	Ph:  81-22-717-7205
			Email: k-miura@surg1.med.tohoku.ac.jp
Nagano
	Iida
	Iida Municipal Hospital
		Noriyuki Akita, MD	Ph:  81-265-21-1255
	Komagane
	Showa-Inan General Hospital
		Ken Hayashi, MD	Ph:  81-265-52-5800
	Matsumoto
	Aizawa Hospital
		Katsunori Tauchi, MD, PhD	Ph:  81-263-33-8600
	Nagano-shi
	Nagano Municipal Hospital
		Yasuhiro Munakata, MD	Ph:  81-26-295-1199
	Nakano
	Hokushin Hospital
		Kiyofumi Yamagishi, MD	Ph:  81-269-22-2151
Nagasaki
	Magasaki-shi
	Nagasaki University Hospital of Medicine and Dentistry
		Masashi Haraguchi, MD, PhD	Ph:  81-95-849-7316
	Nagasaki-shi
	Japanese Red Cross Nagasaki Genbaku Hospital
		Takazaki Nakazaki, MD	Ph:  81-95-847-1511
	Omura
	National Hospital Organization Nagasaki Medical Center
		Kousei Miyashita, MD, PhD	Ph:  81-957-52-3121
	Sasebo-shi
	Sasebo City General Hospital
		Hiroshi Ishikawa, MD	Ph:  81-956-24-1515
Nara
	Kashihara
	Nara Medical University Cancer Center
		Tomohide Mukogawa, MD	Ph:  81-744-22-3051
	Nara
	Saiseikai Nara Hospital
		Michiyoshi Hisanaga, MD, PhD	Ph:  81-742-36-1881
	Yamatotakada
	Kenseikai Nara Coloproctology Center
		Contact Person	Ph:  81-745-53-5471
Niigata
	Nagaoka
	Nagaoka Chuo General Hospital
		Atsushi Nishimura, MD	Ph:  81-258-35-3700
	Niigata
	Saiseikai Niigata Daini Hospital
		Yasuo Sakai, MD	Ph:  81-25-233-6161
	Niigata-shi
	Niigata Cancer Center Hospital
		Yasumasa Takii, MD	Ph:  81-25-266-5111
	Niigata University Medical and Dental Hospital
		Tsuneo Iiai, MD	Ph:  81-25-227-2228
Oita
	Yufu-shi
	Oita University Hospital
		Seigo Kitano, MD, PhD	Ph:  81-97-586-5840
Okayama
	Kurashiki
	Kurashiki Central Hospital
		Tadashi Itoh, MD, PhD	Ph:  81-86-422-0210
	Kurashiki-shi
	Kawasaki Medical School
		Kazuki Yamashita, MD	Ph:  81-86-462-1111
	Okayama
	Okayama University Medical School
		Nagahide Matsubara, MD	Ph:  81-86-235-7257
Okinawa
	Okinawa
	Nakagami Hospital
		Zenji Miyazato, MD	Ph:  81-98-939-1300
Osaka
	Hirakata
	Hoshigaoka Koseinenkin Hospital
		Mitsutoshi Tatsumi, MD, PhD	Ph:  81-72-840-2641
	Izumiotsu
		Tsunehiro Maeda, MD	Ph:  81-752-32-5622
	Izumiotsu Municipal Hospital
		Contact Person	Ph:  81-752-32-5622
	Izumisano
	Rinku General Medical Center
		Masaaki Izukura	Ph:  81-724-69-3111
	Mino
	Minoh City Hospital
		Takeshi Kato, MD, PhD	Ph:  81-72-728-2001
	Moriguchi
	Kansai Medical University Takii Hospital
		Contact Person	Ph:  81-6-6992-1001
			Email: takadahi@takii.kmu.ac.jp
	Osaka
	Higashi Sumiyoshi Morimoto Hospital
		Hiromu Tanaka, MD	Ph:  81-6-6606-0010
	Kitano Hospital
		Arimichi Takabayashi	Ph:  81-6-6312-1221
			Email: atakaba@kitano-hp.or.jp
	Minamiosaka Hospital
		Toshio Ihara, MD	Ph:  81-6-6685-0221
	Nissay Hospital
		Yukou Hamanaka, MD	Ph:  81-6-6543-3581
	Osaka City Juso Hospital
		Yosuke Fukunaga, MD	Ph:  81-6-6150-8000
	Osaka Saiseikai Noe Hospital
		Contact Person	Ph:  81-6-6932-0401
			Email: mdad@alles.or.jp
	Otemae Hospital
		Hiroshi Noro, MD	Ph:  81-6-6941-0484
	Osakasayama
	Kinki University School of Medicine
		Kiyotaka Okuno, MD, PhD	Ph:  81-72-366-0221
	Osaka-shi
	Osaka City General Hospital
		Masayuki Higashino, MD	Ph:  81-6-6929-1221
	Osaka General Medical Center
		Yasuhiro Tanaka, MD	Ph:  81-6-6692-1201
	Osaka Kosei Nenkin Hospital
		Akira Ito, MD	Ph:  81-6-6441-5451
	Osaka Police Hospital
		Masaaki Nakahara, MD	Ph:  81-6-6771-6051
	Sakai
	Bell Land General Hospital
		Masao Kameyama, MD, PhD	Ph:  81-72-234-2001
	Sakai City Hospital
		Contact Person	Ph:  81-72-221-1700
			Email: fukunaga-m@city.sakai.osaka.jp
	Sakai-shi
	Osaka Rosai Hospital
		Junichi Hasegawa, MD	Ph:  81-72-252-3561
	Suita-shi
	Suita Municipal Hospital
		Kohei Murata, MD, PhD	Ph:  81-6-6387-3311
	Takatsuki
	Osaka Medical College
		Junji Okuda, MD, PhD	Ph:  81-72-683-1221
	Tondabayashi
	Saiseikai Tondabayashi Hospital
		Akira Maeda	Ph:  81-721-29-1121
Saga
	Saga
	Saga Prefectural Hospital Koseikan
		Contact Person	Ph:  81-952-24-2171
			Email: orita-h@koseikan.jp
Saitama
	Fukaya
	Fukaya Red Cross Hospital
		Hiroshi Ishikawa, MD, PhD	Ph:  81-48-571-1511
	Hasuda
	Hasuda Hospital
		Contact Person	Ph:  81-48-766-8111
			Email: s-hamada@hasuda-hp.or.jp
	Kawagoe-shi
	Saitama Medical School Hospital
		Hideyuki Ishida, MD	Ph:  81-49-228-3700
	Kitamoto
	Kitasato Institute Medical Center Hospital
		Yohei Yasogawa, MD, PhD	Ph:  81-48-593-1212
	Saitama
	Saitama Social Insurance Hospital
		Kohsei Hisa, MD	Ph:  81-48-832-4951
	Saitamaken
	Omiya Medical Center ofJichi Medical School
		Fumio Konishi, MD, PhD	Ph:  81-48-647-2111
			Email: DZD00740@nifty.ne.jp
	Tokorozawa
	National Defense Medical College
		Hideki Ueno, MD, PhD	Ph:  81-42-995-1637
			Email: ueno@ndmc.ac.jp
	National Hospital Organization - Nishisaitama-Chuo National Hospital
		Contact Person	Ph:  81-42-948-1111
			Email: ikeuchik@wsh.hosp.go.jp
Shiga
	Otsu
	Otsu Municipal Hospital
		Ken Yanagibashi, MD, PhD	Ph:  81-77-522-4607
			Email: kenyanagibashi@msn.com
	Otsu-shi
	Shiga University of Medical Science
		Yoshihiro Endo, MD, PhD	Ph:  81-77-548-2238
Shimane
	Izumo-shi
	Shimane Prefectural Central Hospital
		Nobuhiro Ozaki	Ph:  81-853-22-5111
			Email: osaki@spch.izumo.shimane.jp
Shizuoka
	Fujieda
	Fujieda Municipal General Hospital
		Kennoki Kyo, MD, PhD	Ph:  81-54-646-1111
			Email: kkyo@vega.ocn.ne.jp
	Hamamatsu-shi
	Hamamatsu University School of Medicine
		Toshio Nakamura, MD	Ph:  81-53-435-2279
	Shizuoka
	Shizuoka City Hospital
		Kei Yonezawa, MD, PhD	Ph:  81-54-253-3125
	Shizuoka Municipal Shimizu Hospital
		Iwao Matsuda, MD	Ph:  81-54-336-1111
	Sunto-gun
	Shizuoka Cancer Center
		Masayuki Ishii, MD	Ph:  81-55-989-5222
	Yaizu
	Yaizu Municipal Hospital
		Takeyuki Hiramatsu, MD, PhD	Ph:  81-54-623-3111
Tochigi
	Ohtawawa
	Ohtawara Red Cross Hospital
		Hikaru Tamura, MD, PhD	Ph:  81- 287-23-1122
	Shimotsuga-gun
	Dokkyo University School of Medicine
		Masahiro Tsubaki	Ph:  81-282-86-1111
	Shimotsuke-shi
	Jichi Medical School
		Hisanaga Horie, MD, PhD	Ph:  81-285-58-7371
	Utsunomiya
	Tochigi Cancer Center
		Takashi Matsui, MD	Ph:  81-28-658-5151
Tokushima
	Anan
	Anan Kyoei Hospital
		Contact Person	Ph:  81-884-44-3131
			Email: mich-undo@shirt.ocn.ne.jp
Tokyo
	Bunkyo-ku
	Juntendo University School of Medicine
		Kazuhiro Sakamoto, MD, PhD	Ph:  81-3-3813-3111
	Chuo-ku
	St. Luke's International Hospital
		Hisashi Onodera, MD, PhD	Ph:  81-3-3541-5151
	Fuchu
	Tokyo Metropolitan Fuchu Hospital
		Jun Matsumoto, MD	Ph:  81-42-323-5111
	Higashiyamato
	Higashiyamato General Hospital
		Takashi Omura, MD, PhD	Ph:  81-42-562-1411
	Kodaira
	Showa General Hospital
		Contact Person	Ph:  81-42-461-0052
			Email: miki-kenji@umin.ac.jp
	Komae
	Daisan Hospital
		Katsuhito Suwa, MD	Ph:  81-3-3480-1151
	Meguro-ku
	Toho University Ohashi Hospital
		Yoshihisa Saida, MD, PhD	Ph:  81-3-3468-1251
	Minato-ku
	Toranomon Hospital
		Toshihito Sawada, MD	Ph:  81-3-3588-1111
	Mitaka
	Kyorin University School of Medicine - Mitaka Campus
		Tadahiko Masaki, MD, PhD	Ph:  81-422-47-5511
	Nakano
	Nakano General Hospital
		Ryo Ono, MD, PhD	Ph:  81-3-3382-1231
	Shinjuku-ku
	Social Insurance Chuo General Hospital
		Rikisaburoh Sahara, MD, PhD	Ph:  81-3-3364-0251
	Shinjyuku-ku
	Tokyo Women's Medical University
		Shingo Kameoka, MD, PhD	Ph:  81-3-3353-8111
	Tokyo
	International Medical Center of Japan
		Yukio Saito, MD, PhD	Ph:  81-3-3202-7181
	Japanese Red Cross Medical Center
		Takeshi Endo, MD	Ph:  81-3-3400-1311
	Jikei University School of Medicine Hospital
		Contact Person	Ph:  81-3-3603-2111
			Email: kaz-yosh@yd5.so-net.ne.jp
	Mita Hospital at the International University of Health and Welfare
		Ken-ichi Mafune, MD	Ph:  81-3-3451-8121
			Email: mafune@iuhw.ac.jp
	National Hospital Organization - Tokyo Medical Center
		Contact Person	Ph:  81-3-3411-0111
			Email: smatsumoto@ntmc.hosp.go.jp
	Nippon Medical School
		Kiyonori Furukawa	Ph:  81-3-3822-2131
	NTT Kanto Medical Center
		Contact Person	Ph:  81-3-3448-6557
			Email: fukusima@kmc.mhc.east.ntt.co.jp
	Showa University Toyosu Hospital
		Contact Person	Ph:  81-3-3534-1151
			Email: noboru.y@med.showa-u.ac.jp
	Takasago Kyoritsu Hospital
		Contact Person	Ph:  81-3-3672-1046
			Email: shoji-md@fc4.so-net.ne.jp
	Teikyo University School of Medicine
		Toshiaki Watanabe, MD, PhD	Ph:  81-3-3964-1231
	Toho University School of Medicine
		Tatsuo Teramoto, MD	Ph:  81-3-3762-4151 ext. 3553
			Email: tteramot@med.toho-u.ac.jp
	Tokyo Medical and Dental University
		Kenichi Sugihara, MD, PhD	Ph:  81-3-5803-5261
			Email: k-sugi.srg2@tmd.ac.jp
	Tokyo Metropolitan - Komagome Hospital
		Contact Person	Ph:  81-3-3823-2101
			Email: keiichi@cick.jp
	Tokyo Women's Medical University Medical Center East
		Contact Person	Ph:  81-3-3810-1111
			Email: ogawasu@dnh.twmu.ac.jp
Tottori
	Yonago
	Tottori University - Faculty of Medicine
		Kuniyuki Katano, MD, PhD	Ph:  81-859-38-6567
Toyama
	Takaoka-shi
	Koseiren Takaoka Hospital
		Nozawal Hiroshi, MD	Ph:  81-766-21-3930
	Toyama
	Toyama Red Cross Hospital
		Akira Takehara, MD, PhD	Ph:  81-76-433-2222
	Toyama-shi
	Toyama Prefectural Central Hospital
		Kazuhisa Yabushita, MD, PhD	Ph:  81-76-424-1531
Wakayama
	Shingu
	Shingu Municipal Medical Center
		Contact Person	Ph:  81-735-31-3333
			Email: naoyama@hsp.shingu.wakayama.jp
	Tanabe
	Social Insurance Kinan Hospital
		Makio Nagaoka, MD	Ph:  81-739-22-5000
	Wakayama
	Japan Labor Health and Welfare Organization Wakayama Rosai Hospital
		Contact Person	Ph:  81-73-451-3181
			Email: tks-tsuji@wakayamah.rofuku.go.jp
	Wakayama-shi
	Wakayama Medical University
		Tsukasa Hotta, MD, PhD	Ph:  81-73-441-0613
Yamagata
	Yamagata
	Yamagata Prefectural Central Hospital
		Contact Person	Ph:  81-23-685-2626
			Email: toshi.st@ypch.gr.jp
	Yamagata Saisei Hospital
		Contact Person	Ph:  81-23-682-1111
			Email: urayamam@nirty.com
	Yamagata University Hospital
		Contact Person	Ph:  81-23-628-5336
			Email: wkimura@med.id.yamagata-u.ac.jp
Yamaguchi
	Shimonoseki
	National Hospital Organization - Kanmon Medical Center
		Takumi Furuya, MD	Ph:  81-832-22-6216
	Shimonoseki Kosei Hospital
		Toshimasa Okada, MD, PhD	Ph:  81-832-31-5811
	Ube
	Yamaguchi University Graduate School of Medicine
		Masaaki Oka, MD, PhD	Ph:  81-836-22-2262
Yamanashi
	Chu-o-shi
	University of Yamanashi Faculty of Medicine
		Hiroshi Iino, MD, PhD	Ph:  81-55-273-7390