Alternate Title
Basic Trial Information
Objectives
Entry Criteria
Expected Enrollment
Outcomes
Outline
Published Results
Trial Contact Information
Registry Information

Alternate Title

Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation, Radiation Therapy, and/or Surgery in Treating Patients With Ewing's Sarcoma

Basic Trial Information

Phase	Type	Status	Age	Sponsor	Protocol IDs
Phase III	Treatment	Active	Under 50	NCI, Other	EURO-EWING-INTERGROUP-EE99 EBMT-INTERGROUP-EE99, EORTC-62981, GPOH-AUSTRIA-INTERGROUP-EE99, GPOH-GERMANY-INTERGROUP-EE99, SFOP-INTERGROUP-EE99, SWS-SAKK-INTERGROUP-EE99, CCLG-INTERGROUP-EE99, COG-AEWS0331, NCT00020566, AEWS0331

Objectives

Primary

1. Compare the event-free and overall survival of patients with tumor of the Ewing's family treated with standard induction chemotherapy comprising vincristine, dactinomycin, ifosfamide and etoposide (VIDE) followed by consolidation chemotherapy comprising vincristine, dactinomycin, and ifosfamide versus high-dose busulfan and melphalan (Bu-Mel) followed by autologous peripheral blood stem cell (PBSC) transplantation with or without radiotherapy and/or surgery.

Secondary

1. Determine the prognostic significance of EWS-Flil transcript in these patients.
2. Determine the frequency and prognostic value of minimal disease in bone marrow and PBSC, as determined by the presence or absence of EWS-Flil transcript, in these patients.
3. Determine the feasibility and toxicity of VIDE induction chemotherapy in these patients.
4. Determine the response of these patients to VIDE induction chemotherapy.
5. Determine the feasibility and toxicity of VAI consolodation chemotherapy in these patients.
6. Determine the feasibility and toxicity of Bu-Mel consolodation chemotherapy in these patients.
7. Determine event-free survival and overall survival of patients treated with these regimens by prognostic group analysis.

Entry Criteria

Disease Characteristics:

• Histologically confirmed tumor of the Ewing's family of bone or soft tissue
  • Ewing's sarcoma
  • Peripheral primitive neuroectodermal tumor
• Disease meeting one of the following criteria:
  • Resectable localized disease (tumor volume less than 200 mL)
  • Localized disease previously resected at diagnosis
  • Unresectable disease (at least 200 mL tumor volume) but radiotherapy as local control can be delayed
  • Localized disease with early radiotherapy required
  • Pulmonary and/or pleural metastases only
  • Extrapulmonary/pleural metastases (skeleton, bone marrow, lymph nodes)
• No more than 45 days since definitive biopsy

Prior/Concurrent Therapy:

Biologic therapy:

• Not specified

Chemotherapy:

• No prior chemotherapy

Endocrine therapy:

• Not specified

Radiotherapy:

• Not specified

Surgery:

• See Disease Characteristics

Patient Characteristics:

Age:

• Under 50

Performance status:

• Not specified

Life expectancy:

• Not specified

Hematopoietic:

• Not specified

Hepatic:

• Not specified

Renal:

• Renal function normal
• Glomerular filtration rate at least 60 mL/min

Cardiovascular:

• Normal cardiac function
• Fractional shortening at least 29%
• Ejection fraction at least 40%

Other:

• No medical, psychiatric, or social condition that would preclude study participation

Expected Enrollment

Approximately 1,200 patients will be accrued for this study within approximately 7 years.

Outcomes

Event-free survival
Overall survival

Feasibility, toxicity, and response at 1 month following induction therapy
Feasibility and toxicity of consolidation regimens at 1 month following consolidation therapy

Outline

This is a randomized, multicenter study. Patients are stratified according to age and local treatment of the primary tumor (yes vs no).

Patients receive induction chemotherapy comprising vincristine IV on day 1 and ifosfamide IV over 3 hours, doxorubicin IV over 4 hours, and etoposide IV over 1 hour on days 1-3 (VIDE). Treatment repeats every 21 days for 4 courses in the absence of unacceptable toxicity. Peripheral blood stem cells (PBSC) are collected after course 3 and/or 4. Patients are evaluated after course 4. Patients in need of early radiotherapy due to an axial tumor or patients who require radiotherapy to the brain and/or spinal cord (at any time during study) are assigned to group 1. Patients not needing early radiotherapy are assigned to group 2.

• Group 1: Patients receive 2 additional courses of VIDE induction chemotherapy (courses 5 and 6). Patients requiring radiotherapy to the axial tumor also undergo concurrent radiotherapy 5 days a week. Some patients may then undergo surgical resection of the tumor. All patients will then receive vincristine IV on day 1 and dactinomycin IV and ifosfamide IV over 3 hours on days 1 and 2 (VAI). Treatment repeats every 21 days for 8 courses (courses 7-14). Patients requiring radiotherapy to the brain and/or spinal cord also undergo concurrent radiotherapy.
• Group 2: Patients undergo 2 additional courses of VIDE induction chemotherapy (courses 5 and 6). Some patients may then undergo surgical resection of the tumor. All patients receive VAI chemotherapy as in group 1 for 1 course. Patients are randomized to 1 of 2 consolidation therapy arms.
  • Arm I: Patients receive 7 additional courses of VAI chemotherapy (courses 8-14). Patients with unresectable, partially resected, or inadequately resected disease undergo concurrent whole-lung radiotherapy for 6-12 days.
  • Arm II: Patients receive high-dose chemotherapy comprising oral busulfan every 6 hours on days -6 to -3 and melphalan IV over 30 minutes on day -2. Patients receive autologous PBSC IV on day 0. Patients with unresectable, partially resected, or inadequately resected disease undergo concurrent radiotherapy 5 days a week for at least 5 weeks.

Patients are followed every 3 months for 4 years, every 6 months for 1 year, and then periodically thereafter.

Peer Reviewed and Funded or Endorsed by Cancer Research UK

Juergens C, Weston C, Lewis I, et al.: Safety assessment of intensive induction with vincristine, ifosfamide, doxorubicin, and etoposide (VIDE) in the treatment of Ewing tumors in the EURO-E.W.I.N.G. 99 clinical trial. Pediatr Blood Cancer 47 (1): 22-9, 2006.[PUBMED Abstract]

Trial Contact Information

Trial Lead Organizations

University Hospitals of Leicester NHS Trust

Alan Craft, MD, Protocol chair		Ph: 44-191-202-3033

Children's Cancer and Leukaemia Group

Ian Lewis, MD, Protocol chair		Ph: 44-113-206-4985 Email: ian.lewis@leedsth.nhs.uk

Societe Francaise Oncologie Pediatrique

Odile Oberlin, MD, Protocol chair		Ph: 33-1-42-114-180 Email: oberlin@igr.fr

European Organization for Research and Treatment of Cancer

Ian Judson, MA, MD, FRCP, Study coordinator		Ph: 44-20-8722-4303

Gesellschaft fuer Paediatrische Onkologie und Haematologie - Germany

Heribert Juergens, MD, Protocol chair		Ph: 49-251-834-7742 Email: jurgh@uni-muenster.de

Gesellschaft fur Padiatrische Onkologie und Hamatologie - Austria

Helmut Gadner, MD, FRCPG, Protocol chair		Ph: 43-1-401-70-1250

Swiss Group for Clinical Cancer Research

G. Ulrich Exner, MD, Protocol chair		Ph: 41-1-386-3090 Email: guexner@wiss.balgrist.ch

EBMT Solid Tumors Working Party

Ruth Ladenstein, MD, Protocol chair		Ph: 43-1-404-700

Children's Oncology Group

Douglas Hawkins, MD, Protocol chair		Ph: 206-987-3096

U.S.A.
Alabama
	Birmingham
	UAB Comprehensive Cancer Center
		Clinical Trials Office - UAB Comprehensive Cancer Center	Ph:  205-934-0309
Arizona
	Phoenix
	Phoenix Children's Hospital
		Jessica Boklan	Ph:  602-546-0920
Arkansas
	Little Rock
	Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
		Clinical Trial Office - Arkansas Cancer Research Center at University of Arkansas for Medical Sciences	Ph:  501-686-8274
California
	Downey
	Southern California Permanente Medical Group
		Robert Cooper	Ph:  323-783-5307
	Duarte
	City of Hope Comprehensive Cancer Center
		Clinical Trials Office - City of Hope Comprehensive Cancer Center	Ph:  800-826-4673
			Email: becomingapatient@coh.org
	Los Angeles
	Childrens Hospital Los Angeles
		Leo Mascarenhas	Ph:  323-361-2529
	Sacramento
	Kaiser Permanente Medical Center - Oakland
		Vincent Kiley	Ph:  916-474-2326
	San Diego
	Rady Children's Hospital - San Diego
		Clinical Trials Office - Rady Children's Hospital - San Diego	Ph:  858-966-5934
	San Francisco
	UCSF Helen Diller Family Comprehensive Cancer Center
		Clinical Trials Office - UCSF Helen Diller Family Comprehensive Cancer Center	Ph:  877-827-3222
	Stanford
	Stanford Cancer Center
		Clinical Trials Office - Stanford Cancer Center	Ph:  650-498-7061
			Email: cctoffice@stanford.edu
Colorado
	Aurora
	Children's Hospital Center for Cancer and Blood Disorders
		Kelly Maloney	Ph:  720-777-6673
Delaware
	Wilmington
	Alfred I. duPont Hospital for Children
		Clinical Trials Office - Alfred I. duPont Hospital for Children	Ph:  302-651-5755
District of Columbia
	Washington
	Children's National Medical Center
		Clinical Trials Office - Children's National Medical Center	Ph:  202-884-2549
Florida
	Jacksonville
	Nemours Children's Clinic
		Eric Sandler	Ph:  904-697-3793
	Miami
	University of Miami Sylvester Comprehensive Cancer Center - Miami
		University of Miami Sylvester Comprehensive Cancer Center Clinical Trial Matching Service	Ph:  866-574-5124
			Email: Sylvester@emergingmed.com
	Orlando
	Nemours Children's Clinic - Orlando
		Paul Gordon	Ph:  407-650-7330
	Pensacola
	Sacred Heart Cancer Center at Sacred Heart Hospital
		Clinical Trials Office - Sacred Heart Cancer Center	Ph:  850-416-4611
	St. Petersburg
	All Children's Hospital
		Gregory Hale	Ph:  727-767-4176
	Tampa
	St. Joseph's Cancer Institute at St. Joseph's Hospital
		Clinical Trials Office - St. Joseph's Cancer Institute	Ph:  800-882-4123
	West Palm Beach
	Kaplan Cancer Center at St. Mary's Medical Center
		Narayana Gowda	Ph:  561-844-6363
Georgia
	Atlanta
	Winship Cancer Institute of Emory University
		Howard Katzenstein	Ph:  404-785-0853
Illinois
	Chicago
	University of Chicago Cancer Research Center
		Clinical Trials Office - University of Chicago Cancer Research Center	Ph:  773-834-7424
	Springfield
	Simmons Cooper Cancer Institute
		Clinical Trials Office - Simmons Cooper Cancer Institute	Ph:  217-545-7929
Indiana
	Indianapolis
	St. Vincent Indianapolis Hospital
		Clinical Trials Office - St. Vincent Indianapolis Hospital	Ph:  317-338-2194
Iowa
	Iowa City
	Holden Comprehensive Cancer Center at University of Iowa
		Cancer Information Service	Ph:  800-237-1225
Kentucky
	Louisville
	Kosair Children's Hospital
		Clinical Trials Office - Kosair Children's Hospital	Ph:  502-629-5500
			Email: CancerResource@nortonhealthcare.org
Louisiana
	New Orleans
	Children's Hospital of New Orleans
		Clinical Trials Office - Children's Hospital of New Orleans	Ph:  504-894-5377
Maryland
	Baltimore
	Alvin and Lois Lapidus Cancer Institute at Sinai Hospital
		Joseph Wiley	Ph:  410-601-5864
Massachusetts
	Boston
	Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
		Suzanne Shusterman	Ph:  617-632-4901
	Floating Hospital for Children at Tufts - New England Medical Center
		Cynthia Kretschmar	Ph:  617-636-5535
Michigan
	Flint
	Hurley Medical Center
		Clinical Trials Office - Hurley Medical Center	Ph:  810-762-8057
	Grand Rapids
	Butterworth Hospital at Spectrum Health
		David Dickens	Ph:  616-391-2086
	Grosse Pointe Woods
	Van Elslander Cancer Center at St. John Hospital and Medical Center
		Clincial Trials Office - Van Elslander Cancer Center at St. John Hospital and Medical Center	Ph:  313-343-3166
	Kalamazoo
	CCOP - Kalamazoo
		Jeffrey Lobel	Ph:  269-341-6350
	Lansing
	Breslin Cancer Center at Ingham Regional Medical Center
		Clinical Trials Office - Breslin Cancer Center at Ingham Regional Medical Center	Ph:  517-334-2765
Minnesota
	Minneapolis
	Children's Hospitals and Clinics of Minnesota - Minneapolis
		Clinical Trials Office - Children's Hospitals and Clinics of Minnesota	Ph:  612-813-5193
	Masonic Cancer Center at University of Minnesota
		Clinical Trials Office - Masonic Cancer Center at University of Minnesota	Ph:  612-624-2620
	Rochester
	Mayo Clinic Cancer Center
		Clinical Trials Office - All Mayo Clinic Locations	Ph:  507-538-7623
Mississippi
	Jackson
	University of Mississippi Cancer Clinic
		Gail Megason	Ph:  601-984-5220
Missouri
	Kansas City
	Children's Mercy Hospital
		Maxine Hetherington	Ph:  816-234-3265
	St. Louis
	Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
		Robert Hayashi	Ph:  314-454-4118
Nevada
	Las Vegas
	CCOP - Nevada Cancer Research Foundation
		Jonathan Bernstein	Ph:  702-732-0971
		Jonathan Bernstein	Ph:  702-732-1493
New Jersey
	Hackensack
	Hackensack University Medical Center Cancer Center
		Clinical Trials Office - Hackensack University Medical Center Cancer Center	Ph:  201-996-2879
New York
	Bronx
	Albert Einstein Cancer Center at Albert Einstein College of Medicine
		Clinical Trials Office - Albert Einstein Cancer Center at Albert Einstein College of Medicine	Ph:  718-904-2730
			Email: aecc@aecom.yu.edu
	Buffalo
	Roswell Park Cancer Institute
		Clinical Trials Office - Roswell Park Cancer Institute	Ph:  877-275-7724
	New York
	Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center
		Clinical Trials Office - Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center	Ph:  212-305-8615
	Rochester
	James P. Wilmot Cancer Center at University of Rochester Medical Center
		Barbara Asselin	Ph:  585-275-2981
	Syracuse
	SUNY Upstate Medical University Hospital
		Clinical Trials Office - SUNY Upstate Medical University Hospital	Ph:  315-464-5476
North Carolina
	Charlotte
	Blumenthal Cancer Center at Carolinas Medical Center
		Clinical Trials Office - Blumenthal Cancer Center at Carolinas Medical Center	Ph:  704-355-2884
	Presbyterian Cancer Center at Presbyterian Hospital
		Clinical Trials Office - Presbyterian Cancer Center at Presbyterian Hospital	Ph:  704-384-5369
	Durham
	Duke Comprehensive Cancer Center
		Clinical Trials Office - Duke Comprehensive Cancer Center	Ph:  888-275-3853
	Greenville
	Leo W. Jenkins Cancer Center at ECU Medical School
		Clinical Trials Office - Leo W. Jenkins Cancer Center at ECU Medical School	Ph:  252-744-2391
Ohio
	Cincinnati
	Cincinnati Children's Hospital Medical Center
		Clinical Trials Office - Cincinnati Children's Hospital Medical Center	Ph:  513-636-2799
	Cleveland
	Cleveland Clinic Taussig Cancer Center
		Clinical Trials Office - Cleveland Clinic Taussig Cancer Center	Ph:  866-223-8100
	Rainbow Babies and Children's Hospital
		Yousif (Joe) Matloub	Ph:  216-844-3345
	Columbus
	Nationwide Children's Hospital
		Amanda Termuhlen	Ph:  614-722-3552
	Dayton
	Children's Medical Center - Dayton
		Emmett Broxson	Ph:  937-641-3111
	Toledo
	Toledo Hospital
		Clinical Trials Office - Toledo Hospital	Ph:  419-824-1842
Oklahoma
	Oklahoma City
	Oklahoma University Cancer Institute
		Rene McNall-Knapp	Ph:  405-271-5311
Oregon
	Portland
	Legacy Emanuel Hospital and Health Center and Children's Hospital
		Clinical Trials Office - Legacy Emanuel Hospital and Health Center and Children's Hospital	Ph:  503-413-8199
Pennsylvania
	Bethlehem
	Lehigh Valley Hospital - Muhlenberg
		Philip Monteleone	Ph:  484-884-3333
	Hershey
	Penn State Cancer Institute at Milton S. Hershey Medical Center
		Clinical Trials Office - Penn State Cancer Institute at Milton S. Hershey Medical Center	Ph:  717-531-3779
			Email: CTO@hmc.psu.edu
	Philadelphia
	Children's Hospital of Philadelphia
		Richard Aplenc	Ph:  267-426-7252
	Pittsburgh
	Children's Hospital of Pittsburgh
		Clinical Trials Office - Children's Hospital of Pittsburgh	Ph:  412-692-5573
South Carolina
	Charleston
	Hollings Cancer Center at Medical University of South Carolina
		Clinical Trials Office - Hollings Cancer Center at Medical University of South Carolina	Ph:  843-792-9321
	Greenville
	Greenville Hospital Cancer Center
		Clinical Trials Office - Greenville Hospital Cancer Center	Ph:  864-241-6251
Tennessee
	Knoxville
	East Tennessee Children's Hospital
		Ray Pais	Ph:  865-541-8266
Texas
	Amarillo
	Texas Tech University Health Sciences Center School of Medicine - Amarillo
		Curtis Turner	Ph:  806-354-5434X264
	Corpus Christi
	Driscoll Children's Hospital
		Clinical Trials Office - Driscoll Children's Hospital	Ph:  361-694-5311
	Dallas
	Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
		Clinical Trials Office - Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas	Ph:  866-460-4673; 214-648-7097
	Fort Worth
	Cook Children's Medical Center - Fort Worth
		Clinical Trials Office - Cook's Children's Medical Center	Ph:  682-885-2103
	San Antonio
	Methodist Children's Hospital of South Texas
		Michael Grimley	Ph:  210-575-7268
	University of Texas Health Science Center at San Antonio
		Paul Thomas	Ph:  210-704-2187
	Temple
	CCOP - Scott and White Hospital
		Arlynn Mulne	Ph:  254-724-2006
Utah
	Salt Lake City
	Primary Children's Medical Center
		Phillip Barnette	Ph:  801-662-4700
Virginia
	Falls Church
	Inova Fairfax Hospital
		Clinical Trials Office - Inova Fairfax Hospital	Ph:  703-208-6650
	Norfolk
	Children's Hospital of The King's Daughters
		Eric Lowe	Ph:  757-668-7243
Washington
	Seattle
	Children's Hospital and Regional Medical Center - Seattle
		Julie Park	Ph:  206-987-2106
	Spokane
	Providence Cancer Center at Sacred Heart Medical Center
		Judy Felgenhauer	Ph:  509-474-2777
	Tacoma
	Mary Bridge Children's Hospital and Health Center - Tacoma
		Ronald Louie	Ph:  253-403-3481
West Virginia
	Charleston
	West Virginia University Health Sciences Center - Charleston
		Allen Chauvenet	Ph:  304-388-1552
Wisconsin
	Green Bay
	St. Vincent Hospital Regional Cancer Center
		Clinical Trials Office - St. Vincent Hospital Regional Cancer Center	Ph:  920-433-8889
	Marshfield
	Marshfield Clinic - Marshfield Center
		Clinical Trials Office - Marshfield Clinic - Marshfield Center	Ph:  800-782-1581 ext. 94457
	Milwaukee
	Midwest Children's Cancer Center at Children's Hospital of Wisconsin
		Michael Kelly	Ph:  414-456-4170
Australia
New South Wales
	Westmead
	Westmead Institute for Cancer Research at Westmead Hospital
		Geoffrey McCowage	Ph:  61298452122
Queensland
	Brisbane
	Royal Children's Hospital
		Helen Irving	Ph:  617-3636-8671
South Australia
	North Adelaide
	Women's and Children's Hospital
		Maria Kirby	Ph:  61881617411
Western Australia
	Perth
	Princess Margaret Hospital for Children
		Catherine Cole	Ph:  011-6189340-8238
Austria
	Graz
	Universitaet Kinderklinik
		Christian Urban	Ph:  43-0316-385-2605
	Vienna
	St. Anna Children's Hospital
		Helmut Gadner, MD, FRCPG	Ph:  43-1-401-70-1250
		Ruth Ladenstein, MD	Ph:  43-1-404-700
Belgium
	Brussels
	Cliniques Universitaires Saint-Luc
		B. Brichard, MD	Ph:  32-2-764-1111
	Institut Jules Bordet
		Contact Person	Ph:  32-2-541-3570
	Edegem
	Universitair Ziekenhuis Antwerpen
		Contact Person	Ph:  32-821-3000
	Ghent
	Universitair Ziekenhuis Gent
		Contact Person	Ph:  32-9-240-5525
Canada
	Quebec
	Centre Hospitalier Universitaire de Quebec
		Bruno Michon	Ph:  418-656-4141X47191
Alberta
	Edmonton
	University of Alberta Hospital
		Sunil Jayantilal` Desai	Ph:  780-407-8829
British Columbia
	Vancouver
	Children's & Women's Hospital of British Columbia
		Mason Bond	Ph:  604-875-2322
Manitoba
	Winnipeg
	CancerCare Manitoba
		Rochelle Yanofsky	Ph:  204-787-4163
Newfoundland and Labrador
	St. John's
	Janeway Children's Health and Rehabilitation Centre
		John (Jack) Hand	Ph:  709-777-4799
Nova Scotia
	Halifax
	IWK Health Centre
		Margaret Yhap	Ph:  902-470-8778
Ontario
	Toronto
	Hospital for Sick Children
		Sylvain Baruchel	Ph:  416-813-7795
Quebec
	Montreal
	Hopital Sainte Justine
		Yvan Samson	Ph:  418-656-4141x47191
		Yvan Samson	Ph:  514-345-4969
Saskatchewan
	Regina
	Allan Blair Cancer Centre at Pasqua Hospital
		Mansoor Haq	Ph:  306-766-2498
	Saskatoon
	Saskatoon Cancer Centre at the University of Saskatchewan
		Kaiser Ali	Ph:  306-655-2744
Denmark
	Aarhus
	Aarhus Universitetshospital - Aarhus Sygehus
		Contact Person	Ph:  45-861-25-555
	Copenhagen
	Copenhagen County Herlev University Hospital
		Contact Person	Ph:  45-44-88-3499
France
	Villejuif
	Institut Gustave Roussy
		Odile Oberlin, MD	Ph:  33-1-42-114-180
			Email: oberlin@igr.fr
Germany
	Berlin
	Charite University Hospital - Campus Virchow Klinikum
		Contact Person	Ph:  49-30-450-552-818
	Bonn
	Kinderklinik der Universitaet Bonn
		Udo Bode, MD	Ph:  49-228-2873-3215
			Email: udo.bode@ukb.uni-bonn.de
	Bremen
	Klinikum Bremen-Mitte
		Arnulf Pekrun, MD, PhD	Ph:  49-421-497-3656
			Email: arnulf.pekrun@klinikum-bremen-mitte.de
	Dresden
	Universitatsklinikum Carl Gustav Carus
		Ingrid Lauterbach, MD	Ph:  49-351-458-2340
	Duesseldorf
	Universitaetsklinikum Duesseldorf
		Arndt Borkhardt	Ph:  49-211-311-7990
	Essen
	Universitaetsklinikum Essen
		Contact Person	Ph:  49-72-311
	Frankfurt
	Klinikum der J.W. Goethe Universitaet
		Thomas Klingebiel, MD	Ph:  49-69-6301-5094
			Email: thomas.klingebiel@kgu.de
	Freiburg
	Universitaetskinderklinik - Universitaetsklinikum Freiburg
		Charlotte Niemeyer, MD	Ph:  49-761-270-4506
			Email: charlotte.niemeyer@uniklinik-freiburg.de
	Universitaetsklinikum Freiburg
		J. Heinz, MD	Ph:  49-761-270-7365
	Goettingen
	Universitaetsklinikum Goettingen
		Lothar Schweigerer, MD	Ph:  49-551-398-600
	Hamburg
	University Medical Center Hamburg - Eppendorf
		D. K. Hossfeld, MD, PhD	Ph:  49-404-2803-2960
			Email: dk.hossfeld@uke.uni-hamburg.de
	Hannover
	Medizinische Hochschule Hannover
		Karl Welte, MD	Ph:  49-511-532-6710
			Email: welte.karl.h@mh-hannover.de
	Heidelberg
	Universitaets-Kinderklinik Heidelberg
		Andreas Kulozik, MD, PhD	Ph:  49-6221-564-555
			Email: andreas.kulozik@med.uni-heidelberg.de
	Universitatsklinikum Heidelberg
		G. Egerer, MD	Ph:  49-6221-568-011
	Homburg
	Universitaetsklinikum des Saarlandes
		Norbert Graf	Ph:  49-6841-162-4000
	Jena
	Universitaets - Kinderklinik
		Felix Zintl, MD	Ph:  49-3641-938-270
	Leipzig
	Universitaets - Kinderklinik
		U. Bierbach, MD
	Muenster
	Klinik und Poliklinik fuer Kinder und Jugendmedizin - Universitaetsklinikum Muenster
		Heribert Juergens, MD	Ph:  49-251-834-7742
			Email: jurgh@uni-muenster.de
	Medizinische Klinik und Poliklinik A - Universitaetsklinikum Muenster
		Wolfgang Berdel, MD	Ph:  49-251-834-7586
			Email: berdel@uni-muenster.de
	Munich
	Kinderklinik d. TU / Schwabing
		Michaela Nathrath, MD	Ph:  49-89-3068-2887
	Klinikum Rechts Der Isar - Technische Universitaet Muenchen
		Christian Peschel, MD	Ph:  49-89-4140-4111
			Email: christian.peschel@lrz.tu-muenchen.de
	Regensburg
	Klinikum der Universitaet Regensburg
		Reinhard Andreesen, MD	Ph:  49-941-944-5001
			Email: reinhard.andreesen@klinik.uni-regensburg.de
	Stuttgart
	Olgahospital
		Stefan Bielack, MD	Ph:  49-711-99-24-61
			Email: st.bielack@olgahospital.de
	Tuebingen
	Universitaetsklinikum Tuebingen
		Rupert Handgretinger, MD	Ph:  49-7071-298-2087
Ireland
	Dublin
	Our Lady's Hospital for Sick Children Crumlin
		Fin Breatnach, MD, FRCPE	Ph:  353-1-409-6659
			Email: fin.breatnach@olhsc.ie
Netherlands
	Amsterdam
	Emma Kinderziekenhuis
		Henk Van Den Berg, MD, PhD, MMEd	Ph:  31-20-566-9111
	Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital
		Contact Person	Ph:  31-512-9111
	Leiden
	Leiden University Medical Center
		Marianne Nooij, MD	Ph:  31-71-526-3486
	Nijmegen
	Universitair Medisch Centrum St. Radboud - Nijmegen
		Contact Person	Ph:  31-361-1111
	Rotterdam
	Erasmus MC - Sophia Children's Hospital
		Rob Pieters, MD, MSC, PhD	Ph:  31-10-463-6691
			Email: rob.pieters@erasmusmc.nl
New Zealand
	Auckland
	Starship Children's Health
		Lochie Teague	Ph:  64930749496368
Portugal
	Lisboa
	Instituto Portugues de Oncologia de Francisco Gentil - Centro Regional de Oncologia de Lisboa, SA
		Contact Person	Ph:  351-21-722-9800
Puerto Rico
	Santurce
	San Jorge Children's Hospital
		Luis Clavell	Ph:  787-728-1575
Switzerland
	Basel
	Universitaets-Kinderspital beider Basel
		Michael Paulussen, MD	Ph:  41-61-685-6565
	Zurich
	Balgrist Universitaetsklinik
		G. Ulrich Exner, MD	Ph:  41-1-386-3090
			Email: guexner@wiss.balgrist.ch
United Kingdom
England
	Birmingham
	Birmingham Children's Hospital
		Martin English, MD	Ph:  44-121-333-8412
			Email: martin.english@bch.nhs.uk
	Bristol
	Institute of Child Health at University of Bristol
		Pamela Kearns, MD	Ph:  44-117-342-8260
	Cambridge
	Addenbrooke's Hospital
		Amos Burke, MD	Ph:  44-1223-348-151
	Leeds
	Leeds Cancer Centre at St. James's University Hospital
		Adam Glaser, MD	Ph:  44-113-206-4984
			Email: adam.glaser@leedsth.nhs.uk
	Leicester
	Leicester Royal Infirmary
		Johann Visser, MD	Ph:  44-116-258-5309
			Email: johannes.visser@uhl-tr.nhs.uk
	Liverpool
	Royal Liverpool Children's Hospital, Alder Hey
		Heather McDowell, MD	Ph:  44-151-293-3679
	London
	Great Ormond Street Hospital for Children
		Gill Levitt, MD	Ph:  44-20-7405-9200 ext. 0073
	Middlesex Hospital
		Ananth Shankar, MD	Ph:  44-20-7380-9300 ext. 9950
	Royal Marsden - London
		Contact Person	Ph:  44-20-7352-8171
	University College of London Hospitals
		Contact Person	Ph:  44-20-7636-8333
	Manchester
	Royal Manchester Children's Hospital
		Bernadette Brennan, MD	Ph:  44-161-922-2227
			Email: bernadette.brennan@cmmc.nhs.uk
	Newcastle-Upon-Tyne
	Northern Centre for Cancer Treatment at Newcastle General Hospital
		Conact Person	Ph:  44-191-219-4200
	Sir James Spence Institute of Child Health at Royal Victoria Infirmary
		Alan Craft, MD	Ph:  44-191-202-3033
		Juliet Hale, MD	Ph:  44-191-282-4101
			Email: j.p.hale@ncl.ac.uk
	Nottingham
	Nottingham City Hospital NHS Trust
		Contact Person	Ph:  44-115-969-1169
	Queen's Medical Centre
		Martin Hewitt, MD, BSc, FRCP, FRCPCH	Ph:  44-115-924-9924 ext. 43394
			Email: martin.hewitt@nuh.nhs.uk
	Oxford
	Oxford Radcliffe Hospital
		Kate Wheeler, MD	Ph:  44-186-522-1066
	Sheffield
	Cancer Research Centre at Weston Park Hospital
		Contact Person	Ph:  44-114-226-5000
	Children's Hospital - Sheffield
		Mary Gerrard, MBChB, FRCP, FRCPCH	Ph:  44-114-271-7366
			Email: mary.gerrard@sch.nhs.uk
	Southampton
	Southampton General Hospital
		Janice Kohler, MD, FRCP	Ph:  44-23-8079-6942
	Sutton
	Institute of Cancer Research - Sutton
		Contact Person	Ph:  44-20-8722-4302
Northern Ireland
	Belfast
	Royal Belfast Hospital for Sick Children
		Anthony McCarthy, MD	Ph:  44-289-063-3631
			Email: anthonymcarthy@royalhospital.n.i.nhs.uk
Scotland
	Aberdeen
	Royal Aberdeen Children's Hospital
		Veronica Neefjes	Ph:  44-1224-550-217
	Edinburgh
	Royal Hospital for Sick Children
		W. Hamish Wallace, MD	Ph:  44-131-536-0426
	Glasgow
	Gartnavel General Hospital
		Contact Person	Ph:  44-141-211-3242
	Royal Hospital for Sick Children
		Milind Ronghe, MD	Ph:  44-141-201-9309
	Western Infirmary
		Contact Person	Ph:  44-330-4006
Wales
	Cardiff
	Childrens Hospital for Wales
		Heidi Traunecker, MD, PhD	Ph:  44-29-2074-2285
			Email: heidi.traunecker@cardiffandvale.wales.nhs.uk

Registry Information
Official Title		EURO-E.W.I.N.G. 99 - European Ewing Tumour Working Initiative of National Groups - Ewing Tumour Studies 1999 - EE 99
Trial Start Date		2001-02-09
Trial Completion Date		2011-12-30 (estimated)
Registered in ClinicalTrials.gov		NCT00020566
Date Submitted to PDQ		2001-03-05
Information Last Verified		2009-11-25
NCI Grant/Contract Number		CA98543

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