A drug used to treat chronic lymphocytic leukemia (CLL). It is also used to treat slow-growing B-cell non-Hodgkin lymphoma (NHL) that got worse during or within 6 months after treatment with rituximab. It is also being studied in the treatment of other types of cancer. Bendamustine hydrochloride damages the cell’s DNA and may kill cancer cells. It is a type of alkylating agent. Also called Bendeka and Treanda.