A drug used with other drugs to treat colorectal cancer that has spread to other parts of the body and has not gotten better with chemotherapy. It is also being studied in the treatment of other types of cancer. Ziv-aflibercept blocks the action of a protein called vascular endothelial growth factor (VEGF) and may prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent. Also called vascular endothelial growth factor trap, VEGF Trap, and Zaltrap.