A drug used to treat adults with chronic lymphocytic leukemia or small lymphocytic lymphoma. It is also used to treat adults with mantle cell lymphoma that has already been treated with at least one other therapy. It is also being studied in the treatment of other types of cancer. Acalabrutinib blocks a protein called Bruton’s tyrosine kinase (BTK), which may help keep cancer cells from growing. It is a type of tyrosine kinase inhibitor. Also called Calquence.