A drug used to treat HER2-negative breast cancer that is locally advanced or has spread to other parts of the body. It is used in patients with certain mutations (changes) in the BRCA1 or BRCA2 genes. It is also being studied in the treatment of other types of cancer. Talazoparib tosylate blocks an enzyme involved in many cell functions, including the repair of DNA damage. Blocking this enzyme may help keep cancer cells from repairing their damaged DNA, causing them to die. Talazoparib tosylate is a type of poly (ADP-ribose) polymerase inhibitor. Also called Talzenna.