A drug used with axitinib to treat advanced renal cell carcinoma (a type of kidney cancer) that has not already been treated. It is also used alone or with other drugs to treat certain types of Merkel cell carcinoma, hepatocellular carcinoma (a type of liver cancer), cervical cancer, stomach cancer, gastroesophageal junction cancer, urothelial carcinoma (a type of bladder cancer), Hodgkin lymphoma, primary mediastinal large B-cell lymphoma, non-small cell lung cancer, cancer of the head and neck, and melanoma. Pembrolizumab is also used to treat some types of solid tumors, including colorectal cancer, that have certain mutations in genes involved in DNA repair. It is also being studied in the treatment of other types of cancer. Pembrolizumab binds to a protein called PD-1, which is found on T cells. Pembrolizumab may block PD-1 and help the immune system kill cancer cells. It is a type of monoclonal antibody and a type of immune checkpoint inhibitor. Also called Keytruda.