A research study conducted by researchers and institutions that receive funding or other resources from the National Cancer Institute (NCI). Resources from NCI include programs that provide scientific review and Institutional Review Board (IRB) support and management of patient tissue sample collection and storage. NCI also provides information about the clinical trials, such as regulatory requirements, patient enrollment, funding, and education materials to these researchers. This support allows the people who run the clinical trials more time for patient care and research. NCI-supported trials include trials that are part of NCI’s national networks, such as National Clinical Trials Network (NCTN), NCI Community Oncology Research Program (NCORP), and Experimental Therapeutics Clinical Trials Network (ETCTN). NCI also funds, in full or in part, trials taking place at NCI-designated cancer centers throughout the U.S. and trials taking place at the NIH Clinical Center in Bethesda, Maryland.