Treatment Clinical Trials for Gestational Trophoblastic Disease

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Clinical trials are research studies that involve people. The clinical trials on this list are for gestational trophoblastic disease treatment. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-8 of 8
  • Nivolumab and Ipilimumab in Treating Patients with Rare Tumors

    This clinical trial studies nivolumab and ipilimumab in treating patients with rare tumors. Monoclonal antibodies, such as nivolumab and ipilimumab, may interfere with the ability of tumor cells to grow and spread.
    Location: 733 locations

  • Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients with Germ Cell Tumors

    This partially randomized phase III trial studies how well active surveillance, bleomycin, carboplatin, etoposide, or cisplatin work in treating pediatric and adult patients with germ cell tumors. Active surveillance may help doctors to monitor subjects with low risk germ cell tumors after their tumor is removed. Drugs used in chemotherapy, such as bleomycin, carboplatin, etoposide, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
    Location: 347 locations

  • Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN)

    The purpose of the study is to determine the overall response rate of single agent TRC105 and the combination of TRC105 and bevacizumab in patients with refractory GTN (including choriocarcinoma, placental site trophoblastic tumor (PSTT), and epithelioid trophoblastic tumor (ETT)). Up to 30 patients will be treated.
    Location: 5 locations

  • Brentuximab Vedotin in Treating Patients with Relapsed or Refractory Germ Cell Tumors

    This phase II trial studies how well brentuximab vedotin works in treating patients with germ cell tumors that have come back or do not respond to treatment. Monoclonal antibodies, such as brentuximab vedotin, may interfere with the ability of cancer cells to grow and spread.
    Location: 2 locations

  • Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Recurrent or Progressive Germ Cell Tumors

    This phase II trial studies how well combination chemotherapy and stem cell transplant works in treating patients with recurrent or progressive germ cell tumors. The combination chemotherapy, consisting of gemcitabine hydrochloride, paclitaxel, and oxaliplatin stops the growth of cancer cells by stopping them from dividing or killing them. After treatment, stem cells are collected from the patient's blood and stored. More chemotherapy, including carboplatin, thiotepa, and etoposide, is given at high doses. The stem cells are then returned to the patient to replace the blood-forming cells that were destroyed by the high-dose chemotherapy.
    Location: Children's Hospital Los Angeles, Los Angeles, California

  • Gemcitabine Hydrochloride, Paclitaxel, Oxaliplatin, High-Dose Chemotherapy, and Stem Cell Transplant in Treating Patients with Recurrent or Refractory Central Nervous System Germ Cell Tumors

    This phase II trial studies how well gemcitabine hydrochloride, paclitaxel, oxaliplatin, high dose chemotherapy, and stem cell transplant work in treating patients with central nervous system germ cell tumors that have come back after a period of improvement or that have not responded to previous treatment. Drugs used in chemotherapy, such as gemcitabine hydrochloride, paclitaxel and oxaliplatin work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving chemotherapy before a stem cell transplant helps kill any cancer cells that are in the body and helps make room in the patient’s bone marrow for new blood-forming cells (stem cells) to grow. After treatment, stem cells are collected from the patient's blood and stored. More chemotherapy is then given to prepare the bone marrow for the stem cell transplant. The stem cells are then returned to the patient to replace the blood-forming cells that were destroyed by the chemotherapy. Giving gemcitabine hydrochloride, paclitaxel, oxaliplatin, high dose chemotherapy, and stem cell transplant may work better in treating patients with central nervous system term cell tumors.
    Location: Nationwide Children's Hospital, Columbus, Ohio

  • Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors

    Treatment options for relapsed or refractory germ cell tumors (GCT) patients are limited. High-dose chemotherapy with stem cell rescue (autologous stem cell transplant), when given sequentially, has shown that a subset of patients may be cured. The optimal high-dose chemotherapy regimen, however, is unknown. In this trial, we will use tandem autologous transplants with non-cross resistant conditioning regimens to treat patients with relapsed / refractory GCTs.
    Location: University of Minnesota / Masonic Cancer Center, Minneapolis, Minnesota

  • Accelerated or Standard BEP Chemotherapy in Treating Patients with Intermediate or Poor-Risk Metastatic Germ Cell Tumors

    This randomized phase III trial studies how well an accelerated schedule of bleomycin sulfate, etoposide phosphate, and cisplatin (BEP) chemotherapy works compared to the standard schedule of BEP chemotherapy in treating patients with intermediate or poor-risk germ cell tumors that have spread to other places in the body. Drugs used in chemotherapy, such as bleomycin sulfate, etoposide phosphate, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving BEP chemotherapy on a faster, or “accelerated” schedule may work better with fewer side effects in treating patients with intermediate or poor-risk metastatic germ cell tumors.
    Location: Childrens Oncology Group, Philadelphia, Pennsylvania