Clinical Trials Using Allogeneic Epstein-Barr Virus-Specific Cytotoxic T-Lymphocytes

Clinical trials are research studies that involve people. The clinical trials on this list are studying Allogeneic Epstein-Barr Virus-Specific Cytotoxic T-Lymphocytes. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-2 of 2
  • Modified Immune Cells (EBV-Specific Cytotoxic T Lymphocytes) in Treating Patients with EBV Lymphomas or Other EBV-Associated Cancers

    This phase II trial studies how well Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes (CTLs) work in treating patients with EBV lymphomas or other EBV-associated cancers. EBV-CTLs are special immune cells that may attack abnormal cells. EBV-CTLs are made by taking cells from a healthy person, growing them in a laboratory for several weeks to educate them to recognize and destroy EBV infected cells, and then storing them in a freezer until they are required for treatment. This study may help doctors learn more about responses to treatment and any side effects that may occur in patients treated with EBV-CTLs.
    Location: Memorial Sloan Kettering Cancer Center, New York, New York

  • Epstein-Barr Virus Specific Cytotoxic T-Cells in Treating Patients with Relapsed Acute Lymphoblastic Leukemia Who Have Undergone Donor Stem Cell Transplant

    This phase I trial studies the side effects of Epstein-Barr virus specific cytotoxic T-cells given together with cyclophosphamide in treating patients with acute lymphocytic leukemia that has come back (relapsed) and who have undergone donor stem cell transplant. Vaccines made from a donor's gene-modified T-cells may help the body build an effective immune response to kill cancer cells that express cluster of differentiation (CD)19. Drugs used in chemotherapy, such as cyclophosphamide, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving Epstein-Barr virus specific cytotoxic T-cells together with chemotherapy may kill more cancer cells.
    Location: Memorial Sloan Kettering Cancer Center, New York, New York