Clinical Trials Using Everolimus

Clinical trials are research studies that involve people. The clinical trials on this list are studying Everolimus. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 26-28 of 28

  • Lenvatinib and Everolimus before Surgery in Treating Patients with Locally Advanced or Metastatic Kidney Cancer

    This phase I trial studies how well lenvatinib and everolimus before surgery work in treating patients with kidney cancer that has spread to nearby tissues or lymph nodes or other places in the body. Lenvatinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as everolimus, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving lenvatinib and everolimus may cause kidney cancer to shrink more than either drug taken alone, thus potentially making it possible to remove the tumor with surgery.
    Location: University of Iowa / Holden Comprehensive Cancer Center, Iowa City, Iowa

  • Implantable Microdevice for the Evaluation of Drug Response in Patients with Primary Brain Tumors

    This early phase I trial studies the feasibility and safety of an implantable microdevice for the evaluation of drug response in patients with primary brain tumors. Brain tumors are known to be very different from each other and respond differently to different drugs. It would be very helpful to find out what drugs have the best chance of working in each specific tumor. This research study involves drugs that are released by a small device, as small as the tip of a needle, that is inserted by a neurosurgeon into the tumor at the time of surgery and is then removed by the end of the surgery. The goal of this research study is to prove that these small devices can be used to find out which drugs have better effects on treating tumors.
    Location: 2 locations

  • Implantable Microdevice for the Delivery of Drugs and their Effect on Tumors in Patients with Metastatic or Recurrent Sarcoma

    This early phase I trial studies the side effects of implanting and removing a microdevice in patients with sarcomas that have spread to other places in the body (metastatic) or have come back (recurrent). Microdevices are rice-sized devices that are implanted into tumor tissue and are loaded with 10 different drugs that are delivered at very small doses, or "microdoses," which may only affect a very small, local area inside the tumor. The purpose of this study is to determine which drugs delivered in the microdevice affect tumor tissue in patients with sarcomas.
    Location: M D Anderson Cancer Center, Houston, Texas