Clinical Trials Using Fluorescent Dye LS301

Clinical trials are research studies that involve people. The clinical trials on this list are studying Fluorescent Dye LS301. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

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  • An Imaging Agent (LS301) for the Detection of Cancerous Tissue in Patients with Stage I-II Breast Cancer

    This phase I / II trial studies the side effects and best dose of LS301 and to see how well it works in detecting cancerous tissue when injected prior to surgery in patients with stage I-II breast cancer. LS301 is a substance that acts as a dye or an imaging agent which accumulates in cancer-containing tissue and not in normal tissue and it fluoresces under near-infrared light. Researchers can use special goggles that function under near-infrared light to distinguish between normal tissue and tumor tissue. This study is evaluating the extent to which LS301 can be found in cancerous tissue and not normal tissue by injecting patients with LS301 before surgery and then looking at samples of tissue taken during the routine surgery to see whether the information created by viewing the samples with the goggles matches the results of the routine evaluation of the samples by a pathologist. Using LS301 in conjunction with the goggle system may reduce the incidence of incomplete removal of cancerous tissue and the need for follow-up surgery in patients with breast cancer.
    Location: Siteman Cancer Center at Washington University, Saint Louis, Missouri