Clinical Trials Using Fluorescent Imaging Ligand OTL38

Clinical trials are research studies that involve people. The clinical trials on this list are studying Fluorescent Imaging Ligand OTL38. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-4 of 4
  • Fluorescent Imaging Ligand OTL38 in Diagnosing Cancer in Patients with Resectable Solid Tumors

    This early phase I trial studies how well fluorescent imaging ligand OTL38 (OTL38) works in diagnosing cancer in patients with solid tumors that can be removed by surgery. OTL38 is made by linking folate (a vitamin) to a fluorescent agent, called indole-cyanine. OTL38 and intraoperative imaging during surgery may help doctors to identify solid tumor mass and / or diseased tissue like noncancerous masses.
    Location: University of Pennsylvania / Abramson Cancer Center, Philadelphia, Pennsylvania

  • OTL38 in Imaging Patients with Suspected Pituitary Adenoma Undergoing Surgery

    This phase I trial studies whether fluorescent imaging ligand OTL38 (OTL38) can identify pituitary adenomas during surgery in patients undergoing surgery for suspected pituitary adenomas. Pituitary gland adenomas are benign tumors, but can cause problems because of their size and proximity to the brain, and because of the hormones they can make. Fluorescent imaging ligand OTL38 may cause the tissue of the tumor to glow, and allow it to be seen by doctors using special cameras. This may allow the doctors to make sure the entire tumor is removed during surgery, and may allow them to find other tumors that were not previously identified.
    Location: University of Pennsylvania / Abramson Cancer Center, Philadelphia, Pennsylvania

  • Intraoperative Imaging using OTL38 in Diagnosing Patients with Lung or Pleura Nodules Undergoing Surgery

    This phase II trial studies intraoperative imaging using fluorescent imaging ligand OTL38 (OTL38) in diagnosing patients with lung or pleura nodules undergoing surgery. Drugs, such as OTL38, attach to the cancer and "mark" it. During surgery, the surgeons hold a camera system over the nodule that will excite OTL38. Imaging during surgery may cause the nodule to glow, thus "marking" the cancer and making it easier for surgeons to remove.
    Location: University of Pennsylvania / Abramson Cancer Center, Philadelphia, Pennsylvania

  • OTL38 for Intra-operative Imaging of Folate Receptor Positive Ovarian Cancer

    This is a phase 3, randomized, multi-center, single dose, open label, pivotal study in patients diagnosed with, or with high clinical suspicion of, ovarian cancer scheduled to undergo primary surgical cytoreduction, interval debulking, or recurrent ovarian cancer surgery.
    Location: 9 locations