Clinical Trials Using Indole-3-Carbinol

Clinical trials are research studies that involve people. The clinical trials on this list are studying Indole-3-Carbinol. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

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  • Phase 1 Trial of I3C and Sil in Smokers

    This phase I trial studies the safety and pharmacokinetic profile of the combination of indole-3-carbinol (I3C) and silibinin. I3C is a chemical found in vegetables, such as broccoli and Brussels sprouts. Silibinin is a chemical in milk thistle. Both I3C and silibinin have been shown to prevent tobacco carcinogen-induced lung tumors in mice. This is the first trial in which the combination will be studied in humans, and the first step in determining whether the combination could have a preventive effect against tobacco carcinogen-induced lung cancer.
    Location: University of Minnesota / Masonic Cancer Center, Minneapolis, Minnesota