Clinical Trials Using Paclitaxel Albumin-Stabilized Nanoparticle Formulation

Clinical trials are research studies that involve people. The clinical trials on this list are studying Paclitaxel Albumin-Stabilized Nanoparticle Formulation. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 26-50 of 77

  • Nab-paclitaxel with Cisplatin or Cetuximab in Treating Patients with Stage III-IVb Head and Neck Cancer

    This phase II trial studies how well nab-paclitaxel with cisplatin or cetuximab works in treating patients with stage III-IVb head and neck cancer. Drugs used in chemotherapy, such as nab-paclitaxel and cisplatin, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal antibodies, such as cetuximab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving monoclonal antibody therapy with chemotherapy may kill more cancer cells than chemotherapy alone.
    Location: 3 locations

  • A Phase 2 Study of siG12D LODER in Combination With Chemotherapy in Patients With Locally Advanced Pancreatic Cancer

    In this Phase II study a dose of 2.8 mg (eight 0.35 mg siG12D-LODERs) will be administered in 12-week cycles to patients with unresectable locally advanced pancreatic cancer combined with chemotherapy treatment. Primary Outcome: - Progression-free survival (PFS) in the study population.
    Location: 3 locations

  • Carbon Ion or Conventional Photon Radiation Therapy and Chemotherapy in Treating Patients with Locally Advanced, Unresectable Pancreatic Cancer

    This phase III trial studies how well carbon ion radiation therapy works compared to conventional photon radiation therapy when giving together with chemotherapy in treating patients with pancreatic cancer that has spread from its original site of growth to nearby tissues or lymph nodes and cannot be removed by surgery. Carbon ion radiation therapy uses charged carbon particles to kill tumor cells and shrink tumors. Conventional photon radiation therapy, such as intensity-modulated radiation therapy is a type of 3-dimensional radiation therapy that uses computer-generated images to show the size and shape of the tumor. This type of radiation therapy reduces the damage to healthy tissue near the tumor. Drugs used in chemotherapy, such as gemcitabine hydrochloride and nab-paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Given carbon ion radiation therapy with chemotherapy may kill more tumor cells in patients with pancreatic cancer compared to conventional photon radiation therapy and chemotherapy.
    Location: UT Southwestern / Simmons Cancer Center-Dallas, Dallas, Texas

  • Paricalcitol, Gemcitabine Hydrochloride, and Nab-Paclitaxel in Treating Patients with Metastatic Pancreatic Cancer

    This phase I / II trial studies the side effects and how well paricalcitol, gemcitabine hydrochloride, and nab-paclitaxel work in treating patients with pancreatic cancer that has spread to other places in the body. Paricalcitol is a form of vitamin D that works by blocking a signal in the cancer tumor cells that leads to growth and spreading of the tumor. Drugs used in chemotherapy, such as gemcitabine hydrochloride and nab-paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving paricalcitol, gemcitabine hydrochloride, and nab-paclitaxel may work better in treating patients with metastatic pancreatic cancer.
    Location: 2 locations

  • Nab-paclitaxel followed by Gemcitabine Hydrochloride in Treating Pediatric Participants with Newly-Diagnostic, Relapsed or Refractory Solid Tumors

    This phase I trial studies the side effects and best dose of nab-paclitaxel when given together with gemcitabine hydrochloride in treating pediatric participants with solid tumors that are newly-diagnostic, have come back, or do not respond to treatment. Nab-paclitaxel may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as gemcitabine hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, or by stopping them from dividing, or by stopping them from spreading. Giving nab-paclitaxel in combination with gemcitabine hydrochloride, may work better in treating pediatric participants with solid tumors.
    Location: 2 locations

  • AZD9150 Plus Durvalumab Alone or in Combination With Chemotherapy in Patients With Advanced, Solid Tumours and in Patients With Non-Small-Cell Lung Cancer

    This is a phase Ib / II, open-label multicentre study to assess the safety, tolerability, pharmacokinetics and preliminary anti-tumour activity of AZD9150 plus durvalumab alone or in combination with chemotherapy in patients with advanced, solid tumours and subsequently in patients with non-small-cell lung cancer (NSCLC).
    Location: 2 locations

  • Nab-Paclitaxel and Pembrolizumab in Treating Patients with Hormone Receptor-Positive Breast Cancer before Surgery

    This randomized pilot clinical trial studies how well nab-paclitaxel and pembrolizumab work in treating patients with hormone receptor-positive breast cancer before surgery. Drugs used in chemotherapy, such as nab-paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving nab-paclitaxel and pembrolizumab may work better at treating patients with hormone receptor-positive breast cancer.
    Location: 2 locations

  • A Study of LY3200882 in Participants With Solid Tumors

    The main purpose of this study is to evaluate the safety of the study drug known as LY3200882 in participants with solid tumors.
    Location: 2 locations

  • Study to Evaluate CORT125134 in Combination With Nab-paclitaxel in Patients With Solid Tumors

    The purpose of this study is to assess the safety of the combination of CORT125134, a novel glucocorticoid receptor (GR) antagonist, and nab- paclitaxel in patients with solid tumors and to determine the preliminary efficacy of the combination of CORT125134 and nab-paclitaxel. The structure for the study is a single arm, non-randomized, open- label, multicenter trial with no control group.
    Location: 2 locations

  • Ulixertinib with Nab-Paclitaxel and Gemcitabine Hydrochloride in Treating Patients with Metastatic Pancreatic Cancer

    This phase Ib trial studies the side effects of ulixertinib with nab-paclitaxel and gemcitabine hydrochloride in treating patients with pancreatic cancer that has spread to other places in the body. Ulixertinib and gemcitabine hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as nab-paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving ulixertinib and gemcitabine hydrochloride together with nab-paclitaxel may kill more tumor cells.
    Location: 2 locations

  • Beta-lapachone Prodrug ARQ 761 and Combination Chemotherapy in Treating Patients with Pancreatic Cancer That Is Metastatic, Recurrent, or Cannot Be Removed by Surgery

    This phase I / Ib trial studies the side effects and best dose of beta-lapachone prodrug ARQ 761 when given together with gemcitabine hydrochloride and nab-paclitaxel in treating patients with pancreatic cancer that has spread to other places in the body, cannot be removed by surgery, or has come back. Drugs used in chemotherapy, such as beta-lapachone prodrug ARQ 761, gemcitabine hydrochloride, and nab-paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
    Location: 2 locations

  • Carboplatin and Nab-paclitaxel with Pembrolizumab in Treating Patients with Stage IIIB or IV Non-small Cell Lung Cancer That is Unable To Be Removed with Surgery

    This phase I / II trial studies the side effects and best dose of pembrolizumab when given with carboplatin and paclitaxel albumin-stabilized nanoparticle formulation (nab-paclitaxel) and how well they work in treating patients with non-small cell lung cancer that is unable to be removed with surgery. Drugs used in chemotherapy, such as carboplatin and paclitaxel albumin-stabilized nanoparticle formulation, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Monoclonal antibodies, such as pembrolizumab, may block tumor growth in different ways by targeting certain cells. Giving monoclonal antibody therapy with chemotherapy may be a better treatment for non-small lung cancer.
    Location: 2 locations

  • A Phase I / II / Pharmacodynamic Study of Hydroxychloroquine in Combination With Gemcitabine / Abraxane to Inhibit Autophagy in Pancreatic Cancer

    In this Phase I / II clinical trial, the investigators seek to pilot the addition of Hydroxychloroquine (HCQ) to a commonly-used front-line therapy of pancreatic cancer, gemcitabine / nab-paclitaxel. The investigators plan a run-in to define tolerable doses, and will explore doses of 800 and 1200 mg / day in successive cohorts of 6 patients. The investigators will assess toxicity continuously, and determine the dose for the Phase II trial based on standard toxicity criteria.
    Location: 2 locations

  • A Study of Pembrolizumab (MK-3475) With or Without Maintenance Olaparib in First-line Metastatic Squamous Non-small Cell Lung Cancer (NSCLC, MK-7339-008 / KEYLYNK-008)

    The current study will compare pembrolizumab (MK-3475) plus maintenance olaparib, vs. pembrolizumab plus maintenance olaparib placebo for the treatment of squamous NSCLC. The study's 2 primary hypotheses are: 1. Pembrolizumab plus maintenance olaparib is superior to pembrolizumab plus maintenance olaparib placebo with respect to progression-free survival (PFS) per RECIST 1.1 by blinded independent clinical review (BICR). 2. Pembrolizumab plus maintenance olaparib is superior to pembrolizumab plus maintenance olaparib placebo with respect to overall survival (OS).
    Location: Wayne State University / Karmanos Cancer Institute, Detroit, Michigan

  • Durvalumab in Combination with Chemotherapy in Treating Patients with Advanced Solid Tumors, (DURVA+ study)

    This phase II trial studies the side effects of durvalumab when given together with chemotherapy in treating patients with solid tumors that have spread to others places in the body. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Drugs used in chemotherapy, such as gemcitabine, liposomal doxorubicin, capecitabine, carboplatin, paclitaxel, and nab-paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving chemotherapy with durvalumab may improve how immune cells respond and attack tumor cells.
    Location: National Cancer Institute Developmental Therapeutics Clinic, Bethesda, Maryland

  • TTX-030 Single Agent and in Combination With Immunotherapy or Chemotherapy for Patients With Advanced Cancers

    This is a phase 1 / 1b study of TTX-030, an antibody that inhibits CD39 enzymatic activity, leading to accumulation of pro-inflammatory adenosine triphosphate (ATP) and reduction of immunosuppressive adenosine, which may change the tumor microenvironment and promote anti-tumor immune response. This trial will study the safety, tolerability, pharmacokinetics, and anti-tumor activity of TTX-030 as a single agent and in combination with an approved anti-PD-1 immunotherapy and standard chemotherapies.
    Location: 2 locations

  • A Study to Evaluate Safety / Tolerability of Immunotherapy Combinations in Participants With Triple-Negative Breast Cancer and Gynecologic Malignancies

    This is a Phase 1 / 1b, open-label, dose-escalation, and dose-expansion study to evaluate the safety, tolerability, pharmacokinetic, pharmacodynamic, and clinical activity of AB928 in combination with pegylated liposomal doxorubicin (PLD) with or without IPI-549, or AB928 in combination with nanoparticle albumin-bound-paclitaxel (NP) in participants with advanced metastatic triple-negative breast cancer or ovarian cancer.
    Location: 2 locations

  • 9-ING-41 in Patients With Advanced Cancers

    GSK-3β is a potentially important therapeutic target in human malignancies. The Actuate 1801 Phase 1 / 2 study is designed to evaluate the safety and efficacy of 9-ING-41, a potent GSK-3β inhibitor, as a single agent and in combination with cytotoxic agents, in patients with refractory cancers.
    Location: 2 locations

  • Nab-Paclitaxel, Gemcitabine, and Hypofractionated Ablative Proton Therapy in Treating Patients with Locally Advanced Pancreatic Cancer

    This phase I trial studies the side effects and best dose of nab-paclitaxel and gemcitabine when given together with hypofractionated ablative proton beam radiation therapy in treating patients with pancreatic cancer that has spread to nearby tissue or lymph nodes. Drugs used in chemotherapy, such as nab-paclitaxel and gemcitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells and have fewer side effects. Giving nab-paclitaxel, gemcitabine, and proton beam radiation therapy may work better in treating patients with pancreatic cancer.
    Location: University of Maryland / Greenebaum Cancer Center, Baltimore, Maryland

  • Bemcentinib with Nab-Paclitaxel, Gemcitabine, and Cisplatin in Treating Patients with Metastatic or Recurrent Pancreatic Cancer

    This phase Ib / II trial studies how well bemcentinib in combination with nab-paclitaxel, gemcitabine, and cisplatin work in treating patients with pancreatic cancer that has spread to other places in the body or that has come back. Bemcentinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as nab-paclitaxel, gemcitabine, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving bemcentinib with nab-paclitaxel, gemcitabine, and cisplatin may work better in treating patients with pancreatic cancer.
    Location: UT Southwestern / Simmons Cancer Center-Dallas, Dallas, Texas

  • Study of Efficacy and Safety of Pembrolizumab Plus Platinum-based Doublet Chemotherapy With or Without Canakinumab in Previously Untreated Locally Advanced or Metastatic Non-squamous and Squamous NSCLC Subjects

    This is a phase III study of pembrolizumab plus platinum-based doublet chemotherapy with or without canakinumab in previously untreated locally advanced or metastatic non-squamous and squamous NSCLC subjects. The study will assess primarily the safety and tolerability (safety run-in part) of pembrolizumab plus platinum-based doublet chemotherapy with canakinumab and then the efficacy (double-blind, randomized, placebo controlled part) of pembrolizumab plus platinum-based doublet chemotherapy with or without canakinumab.
    Location: 4 locations

  • FOLFIRINOX Regimen or Gemcitabine-Nab-paclitaxel Followed by Stereotactic Body Radiation Therapy in Treating Patients with Locally Advanced Inoperable or Borderline Inoperable Pancreatic Cancer

    This pilot clinical trial studies the side effects of fluorouracil, irinotecan hydrochloride, leucovorin calcium and oxaliplatin (FOLFIRINOX regimen) or gemcitabine-nab-paclitaxel followed by stereotactic body radiation therapy in treating patients with pancreatic cancer that has spread from its original site to nearby tissues or lymph nodes and cannot be removed by surgery, or is difficult to remove by surgery due to the tumor surrounding major blood channels in the pancreas. Drugs used in chemotherapy, such as the FOLFIRINOX regimen and gemcitabine-nab-paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Stereotactic body radiation therapy uses special equipment to position a patient and deliver radiation to tumors with high precision. This method can kill tumor cells with fewer doses over a shorter period and cause less damage to normal tissue. Giving the FOLFIRINOX regimen or gemcitabine-nab-paclitaxel followed by stereotactic body radiation therapy may work better in treating patients with pancreatic cancer.
    Location: University of Alabama at Birmingham Cancer Center, Birmingham, Alabama

  • Gemcitabine, Nab-paclitaxel, Capecitabine, Cisplatin, and Irinotecan in Treating Patients with Pancreatic Cancer That Has Spread to Other Places in the Body

    This phase I / II trial studies the side effects and best dose of nab-paclitaxel in combination with gemcitabine, capecitabine, cisplatin, and irinotecan and how well they work in treating patients with pancreatic cancer that has spread to other parts of the body. Drugs used in chemotherapy, such as gemcitabine, nab-paclitaxel, capecitabine, cisplatin, and irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
    Location: Johns Hopkins University / Sidney Kimmel Cancer Center, Baltimore, Maryland

  • CCR2 / CCR5 Antagonist BMS-813160, Nivolumab, Gemcitabine Hydrochloride, and Nab-Paclitaxel in Treating Participants with Borderline Resectable or Locally Advanced Pancreatic Cancer

    This phase I / II trial studies the side effects of CCR2 / CCR5 antagonist BMS-813160, nivolumab, gemcitabine hydrochloride, and nab-paclitaxel and how well they work in treating participants with pancreatic cancer that can be borderline removed by surgery or has spread to nearby tissue or lymph nodes. CCR2 / CCR5 antagonist BMS-813160 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Nivolumab may interfere with the ability of tumor cells to grow and spread. Drugs used in chemotherapy, such as gemcitabine hydrochloride and nab-paclitaxel, may work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving CCR2 / CCR5 antagonist BMS-813160, nivolumab, gemcitabine hydrochloride, and nab-paclitaxel may work better in treating participants with pancreatic cancer.
    Location: Siteman Cancer Center at Washington University, Saint Louis, Missouri

  • Gemcitabine Hydrochloride, Nab-Paclitaxel, and Hydroxychloroquine Sulfate with or without Avelumab in Treating Participants with Resectable Pancreatic Cancer Before Surgery

    This phase II trial studies how well gemcitabine hydrochloride, nab-paclitaxel, and hydroxychloroquine sulfate with or without avelumab work before surgery in treating participants with pancreatic cancer that can be removed by surgery. Drugs used in chemotherapy, such as gemcitabine hydrochloride, nab-paclitaxel, and hydroxychloroquine sulfate, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Monoclonal antibodies, such as avelumab, may interfere with the ability of tumor cells to grow and spread. Giving gemcitabine hydrochloride, nab-paclitaxel, hydroxychloroquine sulfate and avelumab before surgery may work better in treating participants with pancreatic cancer.
    Location: 2 locations