Clinical Trials Using Sildenafil Citrate

Clinical trials are research studies that involve people. The clinical trials on this list are studying Sildenafil Citrate. All trials on the list are supported by NCI.

NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. You may want to think about taking part in a clinical trial. Talk to your doctor for help in deciding if one is right for you.

Trials 1-3 of 3
  • Sorafenib Tosylate, Valproic Acid, and Sildenafil Citrate in Treating Patients with Recurrent or Progressive High-Grade Glioma

    This phase II trial studies how well sorafenib tosylate, valproic acid, and sildenafil citrate work in treating patients with high-grade glioma that has returned (recurrent) or is growing, spreading, or getting worse (progressive). Sorafenib tosylate and valproic acid may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Sildenafil citrate may help with getting sorafenib tosylate into the brain tumor. Giving sorafenib tosylate, valproic acid, and sildenafil citrate may work better in treating patients with high-grade glioma.
    Location: Virginia Commonwealth University / Massey Cancer Center, Richmond, Virginia

  • Sildenafil Citrate in Treating Hand-Foot Skin Reaction in Participants with Cancer

    This early phase I trial studies how well sildenafil citrate works in treating hand-foot skin reaction in participants with cancer. Sildenafil citrate may lessen the severity of hand-foot skin reaction caused by some cancer treatments.
    Location: Northwestern University, Chicago, Illinois

  • Smoking Cessation Program with or without Sildenafil for the Decreasing of Inflammation in the Lungs of Smokers

    This phase IV trial studies how well a smoking cessation program with or without sildenafil works in decreasing inflammation in the lungs of smokers. Smoking cessation programs may help smokers to quit smoking. Sildenafil is a drug that is approved for many different uses including the treatment of pulmonary hypotension and may have an effect on the blood flow in possible injured areas of the lungs. Even if a smoker stops smoking, the harmful effects caused by previous smoking may recruit inflammatory cells to those affected areas, leading to lung injury. This inflammation combined with irregular blood flow in the lungs may lead to emphysema. This study's goal is to measure and compare individual responses to smoking cessation with or without sildenafil, and imaging of the lungs using non-contrast and contrast CT scans to see if there is a possible decrease of inflammation and an increase of blood flow in the lungs.
    Location: University of Iowa / Holden Comprehensive Cancer Center, Iowa City, Iowa