Study to Assess the Efficacy and Safety of Ublituximab + TGR-1202 With or Without Bendamustine and TGR-1202 Alone in Patients With Previously Treated Non-Hodgkins Lymphoma
Status: Active
Description
This research study will evaluate the safety and efficacy of a study drug called TGR-1202 in combination with another study drug called ublituximab with or without bendamustine and TGR-1202 alone as a possible treatment for Non-Hodgkin's Lymphoma (NHL) that has come back or that has not responded to standard treatment.
Eligibility Criteria
Inclusion Criteria
- Diagnosis of Non-Hodgkin's Lymphoma including Diffuse Large B-cell Lymphoma, Follicular, Mantle Cell Lymphoma and Marginal Zone Lymphoma
- Relapsed or refractory to prior standard therapy and subjects who are not candidates for high-dose therapy or autologous stem cell transplant
- Eastern Cooperative Oncology Group (ECOG) score of 0 to 2
Exclusion Criteria
- Any major surgery, chemotherapy or immunotherapy within the last 21 days
- Evidence of hepatitis B virus, hepatitis C virus or known HIV infection
- Autologous hematologic stem cell transplant within 6 months of study entry. Prior Allogeneic hematologic stem cell transplant is excluded
- Prior therapy with a PI3K delta inhibitor
Locations & Contacts
Arizona
Tucson
Banner University Medical Center - Tucson
Status: Active
Name Not Available
Status: Active
Name Not Available
California
Los Angeles
UCLA / Jonsson Comprehensive Cancer Center
Status: Active
Contact: Rosa Bishop
Phone: 310-267-5426
Email: rbishop@mednet.ucla.edu
Status: Active
Contact: Rosa Bishop
Phone: 310-267-5426
Email: rbishop@mednet.ucla.edu
District of Columbia
Washington
MedStar Georgetown University Hospital
Status: Active
Name Not Available
Status: Active
Name Not Available
Florida
Jacksonville
Mayo Clinic in Florida
Status: Active
Name Not Available
Status: Active
Name Not Available
Tampa
Moffitt Cancer Center
Status: Active
Contact: Julio C. Chavez
Phone: 813-745-2069
Email: Julio.C.Chavez@moffitt.org
Status: Active
Contact: Julio C. Chavez
Phone: 813-745-2069
Email: Julio.C.Chavez@moffitt.org
Illinois
Chicago
University of Chicago Comprehensive Cancer Center
Status: Active
Name Not Available
Status: Active
Name Not Available
Kansas
Kansas City
University of Kansas Cancer Center
Status: Active
Name Not Available
Status: Active
Name Not Available
Overland Park
University of Kansas Cancer Center-Overland Park
Status: Active
Name Not Available
Status: Active
Name Not Available
Westwood
University of Kansas Hospital-Westwood Cancer Center
Status: Active
Name Not Available
Status: Active
Name Not Available
Maryland
Baltimore
University of Maryland / Greenebaum Cancer Center
Status: Active
Contact: Nicole M. Glynn-Cunningham
Phone: 410-328-7996
Email: nglynn@umm.edu
Status: Active
Contact: Nicole M. Glynn-Cunningham
Phone: 410-328-7996
Email: nglynn@umm.edu
Towson
UM Saint Joseph Medical Center
Status: Active
Name Not Available
Status: Active
Name Not Available
Michigan
Ann Arbor
University of Michigan Comprehensive Cancer Center
Status: Active
Name Not Available
Status: Active
Name Not Available
Missouri
Kansas City
The University of Kansas Cancer Center-North
Status: Active
Name Not Available
Status: Active
Name Not Available
Lee's Summit
The University of Kansas Cancer Center-Lee's Summit
Status: Active
Name Not Available
Status: Active
Name Not Available
New Hampshire
Lebanon
Dartmouth Hitchcock Medical Center
Status: Active
Name Not Available
Status: Active
Name Not Available
New York
Buffalo
Roswell Park Cancer Institute
Status: Active
Name Not Available
Status: Active
Name Not Available
New York
NYP / Columbia University Medical Center / Herbert Irving Comprehensive Cancer Center
Status: Active
Name Not Available
Status: Active
Name Not Available
Ohio
Cleveland
Case Comprehensive Cancer Center
Status: Active
Name Not Available
Status: Active
Name Not Available
Pennsylvania
Philadelphia
University of Pennsylvania / Abramson Cancer Center
Status: Active
Name Not Available
Status: Active
Name Not Available
Texas
Dallas
UT Southwestern / Simmons Cancer Center-Dallas
Status: Active
Contact: Marcella West Aguilar
Phone: 214-648-1479
Email: marcella.aguilar@utsouthwestern.edu
Status: Active
Contact: Marcella West Aguilar
Phone: 214-648-1479
Email: marcella.aguilar@utsouthwestern.edu
Houston
M D Anderson Cancer Center
Status: Active
Name Not Available
Status: Active
Name Not Available
Washington
Seattle
Fred Hutch / University of Washington Cancer Consortium
Status: Active
Name Not Available
Status: Active
Name Not Available
Wisconsin
Madison
University of Wisconsin Hospital and Clinics
Status: Active
Name Not Available
Status: Active
Name Not Available
Trial Phase & Type
Trial Phase
Trial Type
Treatment
Lead Organization
Lead Organization
TG Therapeutics Inc