Sapanisertib or Pazopanib Hydrochloride in Treating Patients with Locally Advanced or Metastatic Sarcoma

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Status: Active

Description

This partially randomized phase I / II trial studies the side effects and best dose of sapanisertib and to see how well it works compared to pazopanib hydrochloride in treating patients with sarcoma that is too large to be removed (locally advanced) or has spread to other areas of the body (metastatic). Sapanisertib and pazopanib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Eligibility Criteria

Inclusion Criteria

  • Patients must have slides available for submission to central pathology review; this review is mandatory prior to registration to confirm eligibility and proper cohort assignment * HISTOLOGIC COHORT 1: Undifferentiated pleomorphic sarcoma (includes: malignant fibrous histiocytoma, myxofibrosarcoma, high grade sarcoma not otherwise specified [NOS]) * HISTOLOGIC COHORT 2: Leiomyosarcoma (either uterine or extra-uterine) * HISTOLOGIC COHORT 3: Other (either malignant peripheral nerve sheath tumor or synovial sarcoma); during the phase II portion of the study, enrollment will be limited to maximum of 25 patients in this cohort ** Note that the phase I is limited to the histologic subtypes listed above; since patients will be enrolling onto dose cohorts during the phase I, they will not enroll onto specific histologic cohorts, although the histologic subtype informed will be collected during patient enrollment
  • Histologic documentation: Eligible patients must have histopathologically confirmed sarcoma of one of the subtypes listed, by central review
  • Locally advanced or metastatic disease; locally advanced disease is defined as disease not amenable to local therapy such as surgery and/or radiation
  • Measurable disease
  • Progression on at least one prior systemic chemotherapy for advanced, unresectable or metastatic disease; prior adjuvant or neoadjuvant therapy is not included as prior systemic chemotherapy unless treatment occurred within the 6 months prior to study enrollment
  • There is no limit to the number of prior lines of treatment a patient has received
  • No treatment with biological therapy, immunotherapy, chemotherapy, investigational agent for malignancy, or radiation =< 28 days before study registration; no treatment with nitrosourea or mitomycin =< 42 days before study registration
  • No treatment with radiation therapy =< 28 days before study registration
  • Patients should have resolution of any toxic effects of prior therapy (except alopecia) to National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE), version 4.0, grade 1 or less
  • Prior treatment with pazopanib or any phosphoinositide 3-kinase (PI3K), mTOR, protein kinase B (AKT), or dual PI3K/mTOR complex (CREB regulated transcription coactivator [TORC]1/TORC2) inhibitors will be prohibited
  • Not pregnant and not nursing; for women of childbearing potential only, a negative pregnancy test done =< 7 days prior to registration is required
  • Eastern Cooperative Oncology Group (ECOG) performance status =< 1
  • Patient history: patients who have any of the following are NOT eligible: * Central nervous system (CNS): Symptomatic, untreated, or uncontrolled brain metastases present * Heme: Active bleeding or bleeding diathesis * Gastrointestinal (GI): ** Abdominal fistula, GI perforation, or intra-abdominal abscess within 28 days prior to registration ** Acute GI bleed within 28 days of registration * Diabetes mellitus: Patients with diabetes mellitus with inadequate control, based on either a glycosylated hemoglobin (Hgb A1c) of > 7.0 or fasting blood glucose above or equal to 130 mg/dL * Cardiac and vascular disorders: ** History of congenital long QT syndrome or torsades de pointes ** Any arrhythmia that is currently not rate-controlled (rate between 60 and 100) ** Prolongation of corrected QT interval via Fridericia’s formula (QTcF) > 480 msec ** Ongoing unstable angina ** Symptomatic peripheral vascular disease ** Arterial thrombosis within 28 days of registration including transient ischemic attack (TIA), cerebrovascular accident (CVA), myocardial infarction (MI) ** Patients with deep vein thrombosis (DVT) or pulmonary embolism (PE) must be on a stable dose of anticoagulation for 14 days prior to registration ** Uncontrolled hypertension, defined as blood pressure (BP) > 140/90 ** Multi gated acquisition scan (MUGA) with ejection fraction (EF), 50% or echocardiogram (echo) with low EF ** Class III or IV congestive heart failure (CHF) within 28 days of registration
  • Chronic concomitant treatment with proton pump inhibitors must discontinue the drug for 7 days prior to registration on the study
  • Chronic concomitant treatment with strong inhibitors of cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4) inhibitors must discontinue the drug for 14 days prior to registration on the study
  • Chronic concomitant treatment with strong CYP3A4 inducers is not allowed; patients must discontinue the drug 14 days prior to the start of study treatment
  • Absolute neutrophil count (ANC) >= 1,500/mm^3
  • Platelet count >= 100,000/mm^3
  • Creatinine =< 1.5 x upper limit of normal (ULN)
  • Total bilirubin =< 1.5 x upper limit of normal (ULN); unless patient has Gilbert disease
  • Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN); if liver metastases, =< 5 x upper limit of normal (ULN)
  • Urine protein creatinine (UPC) =< 1; if UPC >= 1, then a 24-hour urine protein must be assessed; eligible patients must have a 24-hour urine protein value < 1 g/L
  • Thyroid stimulating hormone (TSH) within normal limits (WNL); supplementation is acceptable to achieve a TSH WNL; in patients with abnormal TSH however if the Free T4 is normal and patient is clinically euthyroid, patient is eligible

Locations & Contacts

Alabama

Birmingham
University of Alabama at Birmingham Cancer Center
Status: Active
Contact: Robert Martin Conry
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org

Alaska

Anchorage
Alaska Breast Care and Surgery LLC
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Alaska Oncology and Hematology LLC
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Alaska Women's Cancer Care
Status: Active
Contact: Alison Katherine Conlin
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org
Anchorage Associates in Radiation Medicine
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Anchorage Oncology Centre
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Katmai Oncology Group
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Providence Alaska Medical Center
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org

Arizona

Tucson
The University of Arizona Medical Center-University Campus
Status: Active
Contact: Andrew S. Kraft
Phone: 520-626-9008
University of Arizona Cancer Center-North Campus
Status: Active
Contact: Andrew S. Kraft
Phone: 800-327-2873

Arkansas

Hot Springs
CHI Saint Vincent Cancer Center Hot Springs
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org

California

Arroyo Grande
PCR Oncology
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Auburn
Sutter Auburn Faith Hospital
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Sutter Cancer Centers Radiation Oncology Services-Auburn
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Berkeley
Alta Bates Summit Medical Center-Herrick Campus
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Burbank
Providence Saint Joseph Medical Center / Disney Family Cancer Center
Status: Active
Contact: Alison Katherine Conlin
Phone: 818-847-4793 Email: Madonna.Johnson@providence.org
Burlingame
Mills-Peninsula Medical Center
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Cameron Park
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Castro Valley
Eden Hospital Medical Center
Status: Active
Contact: Edmund Wing-To Tai
Phone: 510-537-1234
Davis
Sutter Davis Hospital
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Fremont
Palo Alto Medical Foundation-Fremont
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Los Angeles
Los Angeles County-USC Medical Center
Status: Active
Contact: James Shun Dah Hu
Phone: 323-865-0451
USC / Norris Comprehensive Cancer Center
Status: Active
Contact: James Shun Dah Hu
Phone: 323-865-0451
Modesto
Memorial Medical Center
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Mountain View
Palo Alto Medical Foundation-Camino Division
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Palo Alto Medical Foundation-Gynecologic Oncology
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Newport Beach
USC Norris Oncology / Hematology-Newport Beach
Status: Active
Contact: James Shun Dah Hu
Phone: 323-865-0451
Novato
Sutter Cancer Research Consortium
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Palo Alto
Palo Alto Medical Foundation Health Care
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Pasadena
Keck Medical Center of USC Pasadena
Status: Active
Contact: James Shun Dah Hu
Phone: 323-865-0451
Roseville
Sutter Cancer Centers Radiation Oncology Services-Roseville
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Sutter Roseville Medical Center
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Sacramento
Sutter Medical Center Sacramento
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
San Francisco
California Pacific Medical Center-Pacific Campus
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Santa Cruz
Palo Alto Medical Foundation-Santa Cruz
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Santa Rosa
Sutter Pacific Medical Foundation
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Sunnyvale
Palo Alto Medical Foundation-Sunnyvale
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Vacaville
Sutter Cancer Centers Radiation Oncology Services-Vacaville
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Vallejo
Sutter Solano Medical Center / Cancer Center
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org

Colorado

Aurora
University of Colorado Hospital
Status: Active
Contact: Anthony David Elias
Phone: 720-848-0650
Colorado Springs
Penrose-Saint Francis Healthcare
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Rocky Mountain Cancer Centers-Penrose
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Denver
Porter Adventist Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Durango
Mercy Medical Center
Status: Temporarily closed to accrual
Name Not Available
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Southwest Oncology PC
Status: Active
Name Not Available
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Fort Collins
Poudre Valley Hospital
Status: Active
Contact: Anthony David Elias
Phone: 970-297-6150
Golden
Mountain Blue Cancer Care Center
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Lakewood
Rocky Mountain Cancer Centers-Lakewood
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Saint Anthony Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Littleton
Littleton Adventist Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Longmont
Longmont United Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Rocky Mountain Cancer Centers-Longmont
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Parker
Parker Adventist Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Rocky Mountain Cancer Centers-Parker
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Pueblo
Rocky Mountain Cancer Centers - Pueblo
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Saint Mary Corwin Medical Center
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Thornton
Rocky Mountain Cancer Centers-Thornton
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org

Connecticut

New Haven
Smilow Cancer Center / Yale-New Haven Hospital
Status: Active
Contact: Hari A. Deshpande
Phone: 855-476-4569
Yale University
Status: Active
Contact: Hari A. Deshpande
Phone: 203-785-5702

Delaware

Lewes
Beebe Medical Center
Status: Active
Contact: Gregory Andrew Masters
Phone: 302-645-3770 Email: Dmiskin@Beebehealthcare.org
Newark
Christiana Care Health System-Christiana Hospital
Status: Active
Contact: Gregory Andrew Masters
Phone: 302-623-4450 Email: KDempsey@christianacare.org
Christiana Gynecologic Oncology LLC
Status: Temporarily closed to accrual
Contact: Gregory Andrew Masters
Phone: 302-733-6227
Delaware Clinical and Laboratory Physicians PA
Status: Active
Contact: Gregory Andrew Masters
Phone: 302-623-4450 Email: KDempsey@christianacare.org
Helen F Graham Cancer Center
Status: Active
Contact: Gregory Andrew Masters
Phone: 302-623-4450 Email: KDempsey@christianacare.org
Medical Oncology Hematology Consultants PA
Status: Active
Contact: Gregory Andrew Masters
Phone: 302-623-4450 Email: KDempsey@christianacare.org
Regional Hematology and Oncology PA
Status: Active
Contact: Gregory Andrew Masters
Phone: 302-623-4450 Email: KDempsey@christianacare.org
Rehoboth Beach
Beebe Health Campus
Status: Active
Contact: Gregory Andrew Masters
Phone: 302-645-3100 Email: Dmiskin@Beebehealthcare.org
Seaford
Nanticoke Memorial Hospital
Status: Active
Contact: Gregory Andrew Masters
Phone: 302-645-3100 Email: Dmiskin@Beebehealthcare.org
Wilmington
Christiana Care Health System-Wilmington Hospital
Status: Active
Contact: Gregory Andrew Masters
Phone: 302-623-4450 Email: KDempsey@christianacare.org

District of Columbia

Washington
MedStar Georgetown University Hospital
Status: Active
Contact: Pallavi P. Kumar
Phone: 202-444-2223
MedStar Washington Hospital Center
Status: Active
Contact: Pallavi P. Kumar
Phone: 202-877-8839

Florida

Jacksonville
Baptist MD Anderson Cancer Center
Status: Active
Name Not Available
Phone: 904-202-7051
Mayo Clinic in Florida
Status: Active
Contact: Steven Attia
Phone: 855-776-0015

Georgia

Savannah
Lewis Cancer and Research Pavilion at Saint Joseph's / Candler
Status: Active
Contact: Howard A. Zaren
Phone: 888-823-5923 Email: ctsucontact@westat.com
Low Country Cancer Care Associates PC
Status: Temporarily closed to accrual
Contact: Howard A. Zaren
Phone: 912-692-2000
Summit Cancer Care-Candler
Status: Active
Contact: Howard A. Zaren
Phone: 888-823-5923 Email: ctsucontact@westat.com

Idaho

Boise
Saint Alphonsus Cancer Care Center-Boise
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Saint Luke's Mountain States Tumor Institute
Status: Active
Contact: Alison Katherine Conlin
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org
Caldwell
Saint Alphonsus Cancer Care Center-Caldwell
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Coeur D'Alene
Kootenai Medical Center
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Emmett
Walter Knox Memorial Hospital
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Fruitland
Saint Luke's Mountain States Tumor Institute - Fruitland
Status: Active
Contact: Alison Katherine Conlin
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org
Meridian
Idaho Urologic Institute-Meridian
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Saint Luke's Mountain States Tumor Institute - Meridian
Status: Active
Contact: Alison Katherine Conlin
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org
Nampa
Saint Alphonsus Medical Center-Nampa
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Saint Luke's Mountain States Tumor Institute - Nampa
Status: Active
Contact: Alison Katherine Conlin
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org
Post Falls
Kootenai Cancer Center
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Summit Cancer Centers-Post Falls
Status: Active
Contact: Lee Duncan Cranmer
Phone: 855-786-6482
Sandpoint
Kootenai Cancer Clinic
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Twin Falls
Saint Luke's Mountain States Tumor Institute-Twin Falls
Status: Active
Contact: Alison Katherine Conlin
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org

Illinois

Bloomington
Illinois CancerCare-Bloomington
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
Canton
Illinois CancerCare-Canton
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
Carbondale
Memorial Hospital of Carbondale
Status: Active
Contact: Bryan A. Faller
Phone: 618-457-5200 Email: clinical.research@sih.net
Carterville
SIH Cancer Institute
Status: Active
Contact: Bryan A. Faller
Phone: 618-985-3333 Email: clinical.research@sih.net
Carthage
Illinois CancerCare-Carthage
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
Centralia
Centralia Oncology Clinic
Status: Active
Contact: Bryan A. Faller
Phone: 217-876-4740 Email: rhamrick@dmhhs.org
Chicago
Northwestern University
Status: Active
Contact: Mark Agulnik
Phone: 312-695-1301 Email: cancer@northwestern.edu
Decatur
Cancer Care Specialists of Illinois - Decatur
Status: Active
Contact: Bryan A. Faller
Phone: 217-876-4740 Email: rhamrick@dmhhs.org
Decatur Memorial Hospital
Status: Active
Contact: Bryan A. Faller
Phone: 217-876-4740 Email: rhamrick@dmhhs.org
Effingham
Crossroads Cancer Center
Status: Active
Contact: Bryan A. Faller
Phone: 217-876-4740 Email: rhamrick@dmhhs.org
Eureka
Illinois CancerCare-Eureka
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
Galesburg
Illinois CancerCare-Galesburg
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
Western Illinois Cancer Treatment Center
Status: Active
Contact: Bryan A. Faller
Phone: 309-344-2831
Kewanee
Illinois CancerCare-Kewanee Clinic
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
Macomb
Illinois CancerCare-Macomb
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
Maywood
Loyola University Medical Center
Status: Temporarily closed to accrual
Contact: Asha Rebecca Dhanarajan
Phone: 708-226-4357
Ottawa
Illinois CancerCare-Ottawa Clinic
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
Pekin
Illinois CancerCare-Pekin
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
Peoria
Illinois CancerCare-Peoria
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
Methodist Medical Center of Illinois
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
OSF Saint Francis Medical Center
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
Peru
Illinois CancerCare-Peru
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
Valley Radiation Oncology
Status: Active
Contact: Bryan A. Faller
Phone: 815-664-4141
Princeton
Illinois CancerCare-Princeton
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
Springfield
Memorial Medical Center
Status: Active
Contact: Bryan A. Faller
Phone: 217-788-3528
Southern Illinois University School of Medicine
Status: Active
Contact: Bryan A. Faller
Phone: 217-545-7929
Springfield Clinic
Status: Active
Contact: Bryan A. Faller
Phone: 800-444-7541
Swansea
Cancer Care Specialists of Illinois-Swansea
Status: Active
Contact: Bryan A. Faller
Phone: 217-876-4740 Email: rhamrick@dmhhs.org
Southwest Illinois Health Services LLP
Status: Active
Contact: Bryan A. Faller
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org

Iowa

Clive
Medical Oncology and Hematology Associates-West Des Moines
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Mercy Cancer Center-West Lakes
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Council Bluffs
Alegent Health Mercy Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Creston
Greater Regional Medical Center
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Des Moines
Medical Oncology and Hematology Associates-Laurel
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Mercy Medical Center - Des Moines
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Iowa City
University of Iowa / Holden Comprehensive Cancer Center
Status: Active
Contact: Varun Monga
Phone: 800-237-1225
Sioux City
Siouxland Regional Cancer Center
Status: Active
Contact: Donald B. Wender
Phone: 712-252-0088
West Des Moines
Mercy Medical Center-West Lakes
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org

Kansas

Chanute
Cancer Center of Kansas - Chanute
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374 Email: Keisha.humphries@ascension.org
Dodge City
Cancer Center of Kansas - Dodge City
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374 Email: Keisha.humphries@ascension.org
El Dorado
Cancer Center of Kansas - El Dorado
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374 Email: Keisha.humphries@ascension.org
Fort Scott
Cancer Center of Kansas - Fort Scott
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374 Email: Keisha.humphries@ascension.org
Independence
Cancer Center of Kansas-Independence
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374 Email: Keisha.humphries@ascension.org
Kingman
Cancer Center of Kansas-Kingman
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374 Email: Keisha.humphries@ascension.org
Lawrence
Lawrence Memorial Hospital
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374 Email: Keisha.humphries@ascension.org
Liberal
Cancer Center of Kansas-Liberal
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374 Email: Keisha.humphries@ascension.org
Manhattan
Cancer Center of Kansas-Manhattan
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5784 Email: Keisha.humphries@ascension.org
McPherson
Cancer Center of Kansas - McPherson
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374 Email: Keisha.humphries@ascension.org
Newton
Cancer Center of Kansas - Newton
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374 Email: Keisha.humphries@ascension.org
Overland Park
University of Kansas Cancer Center-Overland Park
Status: Active
Contact: Benjamin C. Powers
Phone: 913-945-7552 Email: ctnursenav@kumc.edu
Parsons
Cancer Center of Kansas - Parsons
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374 Email: Keisha.humphries@ascension.org
Pratt
Cancer Center of Kansas - Pratt
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374 Email: Keisha.humphries@ascension.org
Salina
Cancer Center of Kansas - Salina
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374 Email: Keisha.humphries@ascension.org
Wellington
Cancer Center of Kansas - Wellington
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374 Email: Keisha.humphries@ascension.org
Wichita
Associates In Womens Health
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374 Email: Keisha.humphries@ascension.org
Cancer Center of Kansas - Wichita
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374 Email: Keisha.humphries@ascension.org
Cancer Center of Kansas-Wichita Medical Arts Tower
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374 Email: Keisha.humphries@ascension.org
Via Christi Regional Medical Center
Status: Active
Contact: Shaker R. Dakhil
Phone: 800-362-0070 Email: Keisha.humphries@ascension.org
Winfield
Cancer Center of Kansas - Winfield
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374 Email: Keisha.humphries@ascension.org

Kentucky

Bardstown
Flaget Memorial Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Corbin
Commonwealth Cancer Center-Corbin
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Lexington
Saint Joseph Hospital East
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Saint Joseph Radiation Oncology Resource Center
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
University of Kentucky / Markey Cancer Center
Status: Active
Contact: John Lee Villano
Phone: 859-257-3379
London
Saint Joseph London
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Louisville
Jewish Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Jewish Hospital Medical Center Northeast
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Saints Mary and Elizabeth Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Shepherdsville
Jewish Hospital Medical Center South
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org

Louisiana

New Orleans
Ochsner Medical Center Jefferson
Status: Active
Contact: Katrina Slaughter Wade
Phone: 504-703-8712 Email: Gregory.Johnstone@ochsner.org

Maryland

Baltimore
Johns Hopkins University / Sidney Kimmel Cancer Center
Status: Active
Contact: Christian Frederick Meyer
Phone: 410-955-8804 Email: jhcccro@jhmi.edu
MedStar Franklin Square Medical Center / Weinberg Cancer Institute
Status: Active
Contact: Pallavi P. Kumar
Phone: 443-777-7364
Sinai Hospital of Baltimore
Status: Active
Contact: Marvin Jack Feldman
Phone: 410-601-6120 Email: pridgely@lifebridgehealth.org
Randallstown
Northwest Hospital Center
Status: Active
Contact: Marvin Jack Feldman
Phone: 410-601-4673 Email: cancerinstitute@lifebridgehealth.org
Westminster
William E Kahlert Regional Cancer Center / Sinai Hospital
Status: Active
Contact: Marvin Jack Feldman
Phone: 410-871-6400

Massachusetts

Boston
Dana-Farber Cancer Institute
Status: Active
Contact: Priscilla Merriam
Phone: 877-442-3324
Massachusetts General Hospital Cancer Center
Status: Active
Contact: Priscilla Merriam
Phone: 877-726-5130

Michigan

Ann Arbor
Saint Joseph Mercy Hospital
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
University of Michigan Comprehensive Cancer Center
Status: Active
Contact: Rashmi Chugh
Phone: 800-865-1125
Brighton
IHA Hematology Oncology Consultants-Brighton
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Saint Joseph Mercy Brighton
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Brownstown
Henry Ford Cancer Institute¿Downriver
Status: Active
Contact: Ding Wang
Phone: 888-823-5923 Email: ctsucontact@westat.com
Canton
IHA Hematology Oncology Consultants-Canton
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Saint Joseph Mercy Canton
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Caro
Caro Cancer Center
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Chelsea
IHA Hematology Oncology Consultants-Chelsea
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Saint Joseph Mercy Chelsea
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Clarkston
Hematology Oncology Consultants-Clarkston
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Newland Medical Associates-Clarkston
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Clinton Township
Henry Ford Macomb Hospital-Clinton Township
Status: Active
Contact: Ding Wang
Phone: 313-916-1784
Dearborn
Beaumont Hospital-Dearborn
Status: Temporarily closed to accrual
Contact: Christopher M. Reynolds
Phone: 248-551-7695
Henry Ford Medical Center-Fairlane
Status: Active
Contact: Ding Wang
Phone: 888-734-5322
Detroit
Henry Ford Hospital
Status: Active
Contact: Ding Wang
Phone: 313-916-1784
Saint John Hospital and Medical Center
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
East China
Great Lakes Cancer Management Specialists-Doctors Park
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Flint
Genesee Cancer and Blood Disease Treatment Center
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Genesee Hematology Oncology PC
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Genesys Hurley Cancer Institute
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Hurley Medical Center
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Gorsse Pointe Woods
Lymphoma Clinic of Michigan
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Grosse Pointe Woods
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Michigan Breast Specialists-Grosse Pointe Woods
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Jackson
Allegiance Health
Status: Active
Contact: Ding Wang
Phone: 517-788-4800
Lansing
Sparrow Hospital
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Livonia
Hope Cancer Clinic
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Saint Mary Mercy Hospital
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Macomb Township
Great Lakes Cancer Management Specialists-Macomb Medical Campus
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Michigan Breast Specialists-Macomb Township
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Marlette
Saint Mary's Oncology / Hematology Associates of Marlette
Status: Active
Contact: Christopher M. Reynolds
Phone: 989-343-2487
Novi
Henry Ford Medical Center-Columbus
Status: Active
Contact: Ding Wang
Phone: 888-734-5322
Pontiac
21st Century Oncology-Pontiac
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Hope Cancer Center
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Newland Medical Associates-Pontiac
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Saint Joseph Mercy Oakland
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Port Huron
Huron Medical Center PC
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Lake Huron Medical Center
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Rochester Hills
Great Lakes Cancer Management Specialists-Rochester Hills
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Saginaw
Oncology Hematology Associates of Saginaw Valley PC
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Saint Mary's of Michigan
Status: Active
Contact: Christopher M. Reynolds
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org
Sterling Heights
Bhadresh Nayak MD PC-Sterling Heights
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Tawas City
Saint Joseph Health System-Tawas City
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Warren
Advanced Breast Care Center PLLC
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Bhadresh Nayak MD PC-Warren
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671
Great Lakes Cancer Management Specialists-Macomb Professional Building
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Macomb Hematology Oncology PC
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Michigan Breast Specialists-Warren
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Saint John Macomb-Oakland Hospital
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
West Bloomfield
Henry Ford West Bloomfield Hospital
Status: Active
Contact: Ding Wang
Phone: 888-734-5322
West Branch
Saint Mary's Oncology / Hematology Associates of West Branch
Status: Active
Contact: Christopher M. Reynolds
Phone: 989-343-2487
Ypsilanti
Huron Gastroenterology PC
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
IHA Hematology Oncology Consultants-Ann Arbor
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org

Minnesota

Bemidji
Sanford Clinic North-Bemidgi
Status: Active
Contact: Preston D. Steen
Phone: 218-333-5000
Brainerd
Essentia Health Saint Joseph's Medical Center
Status: Active
Contact: Bret E.B. Friday
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org
Deer River
Essentia Health - Deer River Clinic
Status: Active
Name Not Available
Phone: 218-786-3308
Detroit Lakes
Essentia Health Saint Mary's - Detroit Lakes Clinic
Status: Active
Name Not Available
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org
Duluth
Essentia Health Cancer Center
Status: Active
Contact: Bret E.B. Friday
Phone: 218-786-3308 Email: CancerTrials@EssentiaHealth.org
Essentia Health Saint Mary's Medical Center
Status: Active
Contact: Bret E.B. Friday
Phone: 888-203-7267
Miller-Dwan Hospital
Status: Active
Contact: Bret E.B. Friday
Phone: 218-786-3308 Email: CancerTrials@EssentiaHealth.org
Fergus Falls
Lake Region Healthcare Corporation-Cancer Care
Status: Active
Contact: Bret E.B. Friday
Phone: 218-786-3308 Email: CancerTrials@EssentiaHealth.org
Fosston
Essentia Health - Fosston
Status: Active
Name Not Available
Phone: 701-364-6272
Hibbing
Essentia Health Hibbing Clinic
Status: Active
Contact: Bret E.B. Friday
Phone: 218-786-3308 Email: CancerTrials@EssentiaHealth.org
Park Rapids
Essentia Health - Park Rapids
Status: Active
Name Not Available
Phone: 701-364-6272
Rochester
Mayo Clinic
Status: Active
Contact: Steven Attia
Phone: 855-776-0015
Sandstone
Essentia Health Sandstone
Status: Active
Name Not Available
Phone: 701-364-6272
Virginia
Essentia Health Virginia Clinic
Status: Active
Contact: Bret E.B. Friday
Phone: 218-786-3308 Email: CancerTrials@EssentiaHealth.org

Missouri

Bonne Terre
Parkland Health Center-Bonne Terre
Status: Active
Contact: Bryan A. Faller
Phone: 314-996-5569
Cape Girardeau
Saint Francis Medical Center
Status: Active
Contact: Bryan A. Faller
Phone: 573-334-2230 Email: sfmc@sfmc.net
Southeast Cancer Center
Status: Active
Contact: Bryan A. Faller
Phone: 573-651-5550
Creve Coeur
Siteman Cancer Center at West County Hospital
Status: Active
Contact: Brian Andrew Van Tine
Phone: 800-600-3606 Email: info@siteman.wustl.edu
Jefferson City
Capital Region Southwest Campus
Status: Active
Contact: Bryan A. Faller
Phone: 573-632-4814 Email: swooden@mail.crmc.org
Saint Louis
Missouri Baptist Medical Center
Status: Active
Contact: Bryan A. Faller
Phone: 314-996-5569
Siteman Cancer Center-South County
Status: Active
Contact: Brian Andrew Van Tine
Phone: 800-600-3606 Email: info@siteman.wustl.edu
Washington University School of Medicine
Status: Active
Contact: Brian Andrew Van Tine
Phone: 800-600-3606 Email: info@siteman.wustl.edu
Sainte Genevieve
Sainte Genevieve County Memorial Hospital
Status: Active
Contact: Bryan A. Faller
Phone: 314-996-5569
Sullivan
Missouri Baptist Sullivan Hospital
Status: Active
Contact: Bryan A. Faller
Phone: 314-996-5569
Sunset Hills
Missouri Baptist Outpatient Center-Sunset Hills
Status: Active
Contact: Bryan A. Faller
Phone: 314-996-5569

Montana

Anaconda
Community Hospital of Anaconda
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Billings
Billings Clinic Cancer Center
Status: Active
Contact: Benjamin T. Marchello
Phone: 800-996-2663 Email: research@billingsclinic.org
Saint Vincent Healthcare
Status: Temporarily closed to accrual
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Bozeman
Bozeman Deaconess Hospital
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Great Falls
Benefis Healthcare- Sletten Cancer Institute
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Great Falls Clinic
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Helena
Saint Peter's Community Hospital
Status: Active
Contact: Benjamin T. Marchello
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org
Kalispell
Kalispell Regional Medical Center
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Missoula
Community Medical Hospital
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Saint Patrick Hospital - Community Hospital
Status: Active
Contact: Alison Katherine Conlin
Phone: 406-327-3118 Email: amy.hanneman@providence.org

Nebraska

Bellevue
Nebraska Medicine-Bellevue
Status: Active
Contact: Nicole Annette Shonka
Phone: 402-559-6941 Email: unmcrsa@unmc.edu
Grand Island
CHI Health Saint Francis
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Kearney
CHI Health Good Samaritan
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Heartland Hematology and Oncology
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Lincoln
Saint Elizabeth Regional Medical Center
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Omaha
Alegent Health Bergan Mercy Medical Center
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Alegent Health Immanuel Medical Center
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Alegent Health Lakeside Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Creighton University Medical Center
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Hematology and Oncology Consultants PC
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Nebraska Medicine-Village Pointe
Status: Active
Contact: Nicole Annette Shonka
Phone: 402-559-5600
Nebraska Methodist Hospital
Status: Active
Contact: Kirsten M. Hotton Leu
Phone: 402-354-5144
University of Nebraska Medical Center
Status: Active
Contact: Nicole Annette Shonka
Phone: 402-559-6941 Email: unmcrsa@unmc.edu
Papillion
Midlands Community Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org

Nevada

Carson City
Carson Tahoe Regional Medical Center
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Henderson
21st Century Oncology-Henderson
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Cancer and Blood Specialists-Henderson
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada - Henderson
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada-Horizon Ridge
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada-Southeast Henderson
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Las Vegas Cancer Center-Henderson
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Nevada Cancer Specialists-Saint Rose
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Las Vegas
21st Century Oncology
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
21st Century Oncology-Fort Apache
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
21st Century Oncology-Vegas Tenaya
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Ann M Wierman MD LTD
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Cancer and Blood Specialists-Shadow
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Cancer and Blood Specialists-Tenaya
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Cancer Therapy and Integrative Medicine
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada - Central Valley
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada - Northwest
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada-Summerlin
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Desert West Surgery
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
HealthCare Partners Medical Group Oncology / Hematology-Centennial Hills
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
HealthCare Partners Medical Group Oncology / Hematology-Maryland Parkway
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
HealthCare Partners Medical Group Oncology / Hematology-San Martin
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
HealthCare Partners Medical Group Oncology / Hematology-Tenaya
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Las Vegas Cancer Center-Medical Center
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Nevada Cancer Specialists?Oakey
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Nevada Cancer Specialists-Fort Apache
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Nevada Cancer Specialists-Tenaya
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Radiation Oncology Centers of Nevada Central
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Radiation Oncology Centers of Nevada Southeast
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Summerlin Hospital Medical Center
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
University Cancer Center
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
University Medical Center of Southern Nevada
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Pahrump
Hope Cancer Care of Nevada-Pahrump
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Reno
Radiation Oncology Associates
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Renown Regional Medical Center
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Saint Mary's Regional Medical Center
Status: Active
Contact: John Allan Ellerton
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org

New Hampshire

Lebanon
Dartmouth Hitchcock Medical Center
Status: Active
Contact: Rodwell Mabaera
Phone: 800-639-6918 Email: cancer.research.nurse@dartmouth.edu
Manchester
Norris Cotton Cancer Center-Manchester
Status: Active
Contact: Rodwell Mabaera
Phone: 603-629-1828
Nashua
Norris Cotton Cancer Center-Nashua
Status: Active
Contact: Rodwell Mabaera
Phone: 603-577-4282 Email: Laura.A.Menken@hitchcock.org

New Jersey

Hackensack
Hackensack University Medical Center
Status: Active
Contact: Andrew L. Pecora
Phone: 201-996-2879

New Mexico

Albuquerque
Southwest Gynecologic Oncology Associates Inc
Status: Active
Contact: Montaser Shaheen
Phone: 505-272-0530 Email: RDraper@nmcca.org
University of New Mexico Cancer Center
Status: Active
Contact: Vi K. Chiu
Phone: 505-925-0366 Email: LByatt@nmcca.org

New York

Buffalo
Roswell Park Cancer Institute
Status: Active
Contact: Anne C. Grand'Maison
Phone: 800-767-9355 Email: askroswell@roswellpark.org
Glens Falls
Glens Falls Hospital
Status: Active
Contact: Farrah B. Khan
Phone: 518-926-6700
New York
Columbia University / Herbert Irving Cancer Center
Status: Active
Contact: Gary K. Schwartz
Phone: 212-305-6361 Email: nr2616@cumc.columbia.edu
Memorial Sloan Kettering Cancer Center
Status: Active
Contact: William D. Tap
Phone: 212-639-7202
Rochester
University of Rochester
Status: Active
Contact: Paul Michael Barr
Phone: 585-275-5830
White Plains
Dickstein Cancer Treatment Center
Status: Active
Contact: Dan Costin
Phone: 914-849-7582 Email: mcortese@wphospital.org

North Carolina

Asheville
Asheville Hematology-Oncology Associates
Status: Active
Contact: Raymond Thertulien
Phone: 828-681-2917 Email: daniel.figueroa@ahss.org
Chapel Hill
UNC Lineberger Comprehensive Cancer Center
Status: Active
Contact: Juneko E. Grilley-Olson
Phone: 877-668-0683 Email: cancerclinicaltrials@med.unc.edu
Clinton
Southeastern Medical Oncology Center-Clinton
Status: Active
Contact: James N. Atkins
Phone: 919-587-9077 Email: ecooke@cancersmoc.com
Clyde
Haywood Infusion Center
Status: Active
Contact: Raymond Thertulien
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org
Durham
Duke University Medical Center
Status: Active
Contact: Jeffrey Crawford
Phone: 888-275-3853
Goldsboro
Southeastern Medical Oncology Center-Goldsboro
Status: Active
Contact: James N. Atkins
Phone: 919-587-9077 Email: ecooke@cancersmoc.com
Wayne Memorial Hospital
Status: Active
Contact: James N. Atkins
Phone: 919-731-6687 Email: ecooke@cancersmoc.com
Hendersonville
Park Ridge Health
Status: Active
Contact: Raymond Thertulien
Phone: 828-681-2917 Email: Daniel.Figueroa@ahss.org
Jacksonville
Onslow Memorial Hospital
Status: Active
Contact: James N. Atkins
Phone: 910-353-0824 Email: ecooke@cancersmoc.com
Southeastern Medical Oncology Center-Jacksonville
Status: Active
Contact: James N. Atkins
Phone: 910-353-0824 Email: ecooke@cancersmoc.com
Wilson
Southeastern Medical Oncology Center-Wilson
Status: Temporarily closed to accrual
Contact: James N. Atkins
Phone: 800-849-0203

North Dakota

Bismarck
Sanford Bismarck Medical Center
Status: Active
Contact: Preston D. Steen
Phone: 701-323-5760 Email: tamara.fischer@sanfordhealth.org
Fargo
Essentia Health Cancer Center-South University Clinic
Status: Active
Contact: Bret E.B. Friday
Phone: 218-786-3308 Email: CancerTrials@EssentiaHealth.org
Roger Maris Cancer Center
Status: Active
Contact: Preston D. Steen
Phone: 701-234-6161
Sanford Broadway Medical Center
Status: Active
Contact: Preston D. Steen
Phone: 800-437-4010
Sanford Clinic North-Fargo
Status: Temporarily closed to accrual
Contact: Preston D. Steen
Phone: 712-252-0088
Jamestown
Essentia Health - Jamestown Clinic
Status: Active
Name Not Available
Phone: 701-364-6272

Ohio

Cincinnati
Bethesda North Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Good Samaritan Hospital - Cincinnati
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
TriHealth Cancer Institute-Anderson
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
TriHealth Cancer Institute-Westside
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Columbus
Ohio State University Comprehensive Cancer Center
Status: Active
Contact: James Lin Chen
Phone: 800-293-5066 Email: Jamesline@osumc.edu

Oregon

Baker City
Saint Alphonsus Medical Center-Baker City
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Bend
Saint Charles Health System
Status: Active
Contact: Alison Katherine Conlin
Phone: 541-706-2909 Email: nosall@stcharleshealthcare.org
Clackamas
Clackamas Radiation Oncology Center
Status: Active
Contact: Alison Katherine Conlin
Phone: 503-215-2614 Email: CanRsrchStudies@providence.org
Providence Oncology and Hematology Care Southeast
Status: Active
Contact: Alison Katherine Conlin
Phone: 503-215-2614 Email: CanRsrchStudies@providence.org
Coos Bay
Bay Area Hospital
Status: Active
Contact: Alison Katherine Conlin
Phone: 541-269-8392 Email: cherie.cox@bayareahospital.org
Newberg
Providence Newberg Medical Center
Status: Active
Contact: Alison Katherine Conlin
Phone: 503-215-2614 Email: CanRsrchStudies@providence.org
Ontario
Saint Alphonsus Medical Center-Ontario
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Portland
Providence Portland Medical Center
Status: Active
Contact: Alison Katherine Conlin
Phone: 503-215-2614 Email: CanRsrchStudies@providence.org
Providence Saint Vincent Medical Center
Status: Active
Contact: Alison Katherine Conlin
Phone: 503-215-2614 Email: CanRsrchStudies@providence.org
Redmond
Saint Charles Health System-Redmond
Status: Active
Contact: Alison Katherine Conlin
Phone: 541-706-2909

Pennsylvania

Allentown
Lehigh Valley Hospital-Cedar Crest
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Bethlehem
Lehigh Valley Hospital - Muhlenberg
Status: Active
Contact: Christopher M. Reynolds
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Danville
Geisinger Medical Center
Status: Active
Contact: Leonard J. Gitter
Phone: 570-271-5251 Email: HemonCCTrials@geisinger.edu
Hazleton
Geisinger Medical Center-Cancer Center Hazleton
Status: Active
Contact: Leonard J. Gitter
Phone: 570-459-2901 Email: HemonCCTrials@geisinger.edu
Lewisburg
Geisinger Medical Oncology-Lewisburg
Status: Active
Contact: Leonard J. Gitter
Phone: 570-374-8555 Email: HemonCCTrials@geisinger.edu
Lewistown
Lewistown Hospital
Status: Active
Contact: Leonard J. Gitter
Phone: 717-242-7703 Email: HemonCCTrials@geisinger.edu
Pottsville
Geisinger Cancer Services-Pottsville
Status: Active
Contact: Leonard J. Gitter
Phone: 800-275-6401 Email: HemonCCTrials@geisinger.edu
Scranton
Community Medical Center
Status: Active
Contact: Leonard J. Gitter
Phone: 570-703-4768 Email: HemonCCTrials@geisinger.edu
Selinsgrove
Geisinger Medical Oncology-Selinsgrove
Status: Active
Contact: Leonard J. Gitter
Phone: 570-374-8555 Email: HemonCCTrials@geisinger.edu
State College
Geisinger Medical Group
Status: Active
Contact: Leonard J. Gitter
Phone: 570-271-5251 Email: HemonCCTrials@geisinger.edu
Wilkes-Barre
Geisinger Wyoming Valley / Henry Cancer Center
Status: Active
Contact: Leonard J. Gitter
Phone: 570-271-5251 Email: HemonCCTrials@geisinger.edu

South Carolina

Easley
Greenville Health System Cancer Institute-Easley
Status: Active
Contact: Jeffrey Kent Giguere
Phone: 864-241-6251 Email: kwilliams8@ghs.org
Greenville
Greenville Health System Cancer Institute-Butternut
Status: Active
Contact: Jeffrey Kent Giguere
Phone: 864-241-6251 Email: kwilliams8@ghs.org
Greenville Health System Cancer Institute-Eastside
Status: Active
Contact: Jeffrey Kent Giguere
Phone: 864-241-6251 Email: kwilliams8@ghs.org
Greenville Health System Cancer Institute-Faris
Status: Active
Contact: Jeffrey Kent Giguere
Phone: 864-241-6251 Email: kwilliams8@ghs.org
Greenville Memorial Hospital
Status: Active
Contact: Jeffrey Kent Giguere
Phone: 864-241-6251 Email: kwilliams8@ghs.org
Greer
Greenville Health System Cancer Institute-Greer
Status: Active
Contact: Jeffrey Kent Giguere
Phone: 864-241-6251 Email: kwilliams8@ghs.org
Seneca
Greenville Health System Cancer Institute-Seneca
Status: Active
Contact: Jeffrey Kent Giguere
Phone: 864-241-6251 Email: kwilliams8@ghs.org
Spartanburg
Greenville Health System Cancer Institute-Spartanburg
Status: Active
Contact: Jeffrey Kent Giguere
Phone: 864-241-6251 Email: kwilliams8@ghs.org

South Dakota

Sioux Falls
Sanford Cancer Center Oncology Clinic
Status: Active
Contact: Preston D. Steen
Phone: 605-312-3320
Sanford USD Medical Center - Sioux Falls
Status: Active
Contact: Preston D. Steen
Phone: 605-312-3320 Email: OncologyClinicalTrialsSF@SanfordHealth.org

Tennessee

Chattanooga
Memorial Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Hixson
Pulmonary Medicine Center of Chattanooga-Hixson
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Ooltewah
Memorial GYN Plus
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org

Texas

Bryan
Saint Joseph Regional Cancer Center
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org

Vermont

Berlin
Central Vermont Medical Center / National Life Cancer Treatment
Status: Active
Contact: Farrah B. Khan
Phone: 802-225-5400
Burlington
University of Vermont College of Medicine
Status: Active
Contact: Farrah B. Khan
Phone: 802-656-8990
University of Vermont Medical Center
Status: Active
Contact: Farrah B. Khan
Phone: 802-656-4101
Saint Johnsbury
Norris Cotton Cancer Center-North
Status: Active
Contact: Rodwell Mabaera
Phone: 802-473-4100

Washington

Aberdeen
Providence Regional Cancer System-Aberdeen
Status: Active
Contact: Alison Katherine Conlin
Phone: 360-412-8958 Email: deidre.dillon@providence.org
Bellingham
PeaceHealth Saint Joseph Medical Center
Status: Active
Contact: Alison Katherine Conlin
Phone: 360-715-4133 Email: mjohnson9@peacehealth.org
Bremerton
Harrison HealthPartners Hematology and Oncology-Bremerton
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Harrison Medical Center
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Burien
Highline Medical Center-Main Campus
Status: Active
Name Not Available
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Centralia
Providence Regional Cancer System-Centralia
Status: Active
Contact: Alison Katherine Conlin
Phone: 360-412-8958 Email: deidre.dillon@providence.org
Edmonds
Swedish Medical Center-Edmonds
Status: Active
Contact: Alison Katherine Conlin
Phone: 206-215-3086 Email: PCRC-NCORP@Swedish.org
Enumclaw
Saint Elizabeth Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Everett
Providence Regional Cancer Partnership
Status: Active
Contact: Alison Katherine Conlin
Phone: 425-261-3529 Email: marilyn.birchman@providence.org
Federal Way
Saint Francis Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Issaquah
Swedish Cancer Institute-Issaquah
Status: Active
Contact: Alison Katherine Conlin
Phone: 206-215-3086 Email: PCRC-NCORP@Swedish.org
Kennewick
Kadlec Clinic Hematology and Oncology
Status: Active
Contact: Alison Katherine Conlin
Phone: 509-783-4637 Email: research@kadlecmed.org
Lacey
Providence Regional Cancer System-Lacey
Status: Active
Contact: Alison Katherine Conlin
Phone: 360-412-8958 Email: deidre.dillon@providence.org
Lakewood
Saint Clare Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Longview
PeaceHealth Saint John Medical Center
Status: Active
Contact: Alison Katherine Conlin
Phone: 360-514-2016 Email: kmakin-bond@peacehealth.org
Poulsbo
Harrison HealthPartners Hematology and Oncology-Poulsbo
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Seattle
Fred Hutchinson Cancer Research Center
Status: Active
Contact: Lee Duncan Cranmer
Phone: 800-422-6237
Kaiser Permanente Washington
Status: Active
Contact: Alison Katherine Conlin
Phone: 206-215-3086 Email: PCRC-NCORP@Swedish.org
Pacific Gynecology Specialists
Status: Active
Contact: Alison Katherine Conlin
Phone: 206-215-3086 Email: PCRC-NCORP@Swedish.org
Seattle Cancer Care Alliance
Status: Active
Contact: Lee Duncan Cranmer
Phone: 800-804-8824
Swedish Medical Center-Ballard Campus
Status: Active
Contact: Alison Katherine Conlin
Phone: 206-215-3086 Email: PCRC-NCORP@Swedish.org
Swedish Medical Center-Cherry Hill
Status: Active
Contact: Alison Katherine Conlin
Phone: 206-215-3086 Email: PCRC-NCORP@Swedish.org
Swedish Medical Center-First Hill
Status: Active
Contact: Alison Katherine Conlin
Phone: 206-215-3086 Email: PCRC-NCORP@Swedish.org
University of Washington Medical Center
Status: Active
Contact: Lee Duncan Cranmer
Phone: 206-616-8289
Sedro-Woolley
PeaceHealth United General Medical Center
Status: Active
Contact: Alison Katherine Conlin
Phone: 360-788-8240
Shelton
Providence Regional Cancer System-Shelton
Status: Active
Contact: Alison Katherine Conlin
Phone: 360-412-8958 Email: deidre.dillon@providence.org
Spokane
Rockwood Cancer Treatment Center-DHEC-Downtown
Status: Temporarily closed to accrual
Contact: Alison Katherine Conlin
Phone: 509-724-4454 Email: apope@rockwoodclinic.com
Rockwood North Cancer Treatment Center
Status: Temporarily closed to accrual
Contact: Alison Katherine Conlin
Phone: 509-724-4454 Email: apope@rockwoodclinic.com
Spokane Valley
Rockwood Clinic Cancer Treatment Center-Valley
Status: Temporarily closed to accrual
Contact: Alison Katherine Conlin
Phone: 509-724-4454 Email: apope@rockwoodclinic.com
Tacoma
Franciscan Research Center-Northwest Medical Plaza
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Northwest Medical Specialties PLLC
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Vancouver
PeaceHealth Southwest Medical Center
Status: Active
Contact: Alison Katherine Conlin
Phone: 360-514-3940 Email: kmakin-bond@peacehealth.org
Walla Walla
Providence Saint Mary Regional Cancer Center
Status: Active
Contact: Alison Katherine Conlin
Phone: 509-897-5993 Email: Cheryl.Dodd@providence.org
Yelm
Providence Regional Cancer System-Yelm
Status: Active
Contact: Alison Katherine Conlin
Phone: 360-412-8958 Email: deidre.dillon@providence.org

Wisconsin

Ashland
Ashland Memorial Medical Center
Status: Active
Name Not Available
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org
Duluth Clinic Ashland
Status: Active
Contact: Bret E.B. Friday
Phone: 218-786-3308 Email: CancerTrials@EssentiaHealth.org
Chippewa Falls
Marshfield Clinic-Chippewa Center
Status: Active
Contact: Seth Olusegun Fagbemi
Phone: 800-782-8581 Email: oncology.clinical.trials@marshfieldresearch.org
Eau Claire
Marshfield Clinic Cancer Center at Sacred Heart
Status: Temporarily closed to accrual
Contact: Seth Olusegun Fagbemi
Phone: 800-347-0673
Ladysmith
Marshfield Clinic - Ladysmith Center
Status: Active
Contact: Seth Olusegun Fagbemi
Phone: 800-782-8581 Email: oncology.clinical.trials@marshfieldresearch.org
Marshfield
Marshfield Clinic
Status: Active
Contact: Seth Olusegun Fagbemi
Phone: 800-782-8581 Email: oncology.clinical.trials@marshfieldresearch.org
Milwaukee
Froedtert and the Medical College of Wisconsin
Status: Active
Contact: John A. Charlson
Phone: 414-805-4380
Minocqua
Marshfield Clinic-Minocqua Center
Status: Active
Contact: Seth Olusegun Fagbemi
Phone: 800-782-8581 Email: oncology.clinical.trials@marshfieldresearch.org
Rice Lake
Lakeview Medical Center-Marshfield Clinic
Status: Active
Contact: Seth Olusegun Fagbemi
Phone: 800-782-8581 Email: oncology.clinical.trials@marshfieldresearch.org
Marshfield Clinic-Rice Lake Center
Status: Active
Contact: Seth Olusegun Fagbemi
Phone: 800-782-8581 Email: oncology.clinical.trials@marshfieldresearch.org
Stevens Point
Ascension Saint Michael's Hospital
Status: Temporarily closed to accrual
Contact: Seth Olusegun Fagbemi
Phone: 800-347-0673
Marshfield Clinic Stevens Point Center
Status: Active
Contact: Seth Olusegun Fagbemi
Phone: 800-782-8581 Email: oncology.clinical.trials@marshfieldresearch.org
Wausau
Marshfield Clinic-Wausau Center
Status: Active
Contact: Seth Olusegun Fagbemi
Phone: 800-782-8581 Email: oncology.clinical.trials@marshfieldresearch.org
Weston
Marshfield Clinic - Weston Center
Status: Active
Contact: Seth Olusegun Fagbemi
Phone: 800-782-8581 Email: oncology.clinical.trials@marshfieldresearch.org
Wisconsin Rapids
Marshfield Clinic - Wisconsin Rapids Center
Status: Active
Contact: Seth Olusegun Fagbemi
Phone: 800-782-8581 Email: oncology.clinical.trials@marshfieldresearch.org

Wyoming

Cody
Billings Clinic-Cody
Status: Active
Contact: Benjamin T. Marchello
Phone: 800-996-2663 Email: research@billingsclinic.org
Sheridan
Welch Cancer Center
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org

Trial Objectives and Outline

PRIMARY OBJECTIVES:

I. To determine the safety and maximum tolerable dose of sapanisertib (MLN0128 [TAK-228]) within this patient population. (Phase I)

II. To determine the differences in progression-free survival (PFS) in patients with sarcoma who receive MLN0128 (TAK-228) as compared to pazopanib (pazopanib hydrochloride). (Phase II)

SECONDARY OBJECTIVES:

I. To evaluate adverse events. (Phase I/II)

II. To evaluate overall response rate (ORR), clinical benefit rate (CBR), and duration of response (DOR). (Phase I/II)

III. To evaluate time to progression (TTP) and overall survival (OS). (Phase I/II)

TERTIARY OBJECTIVES:

I. To evaluate PFS and secondary endpoints within patients crossing over to MLN0128 (TAK-228), upon disease progression during treatment with pazopanib. (Phase II)

II. To evaluate the 4 month CBR observed within patients treated with MLN0128 (TAK-228) and grouped by histologically defined cohorts. (Phase II)

OUTLINE: This is a phase I, dose-escalation study, followed by a randomized phase II study.

PHASE I: Patients receive sapanisertib orally (PO) on days 1, 8, 15, and 22 in the absence of disease progression or unacceptable toxicity.

PHASE II: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive sapanisertib as in Phase I. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

ARM II: Patients receive pazopanib hydrochloride PO once daily (QD) on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients experiencing disease progression may crossover to Arm I.

After completion of study treatment, patients are followed up at 4 weeks and then every 6 months for 2 years.

Trial Phase & Type

Trial Phase

Phase I/II

Trial Type

Treatment

Lead Organization

Lead Organization
Alliance for Clinical Trials in Oncology

Principal Investigator
William D. Tap

Trial IDs

Primary ID A091304
Secondary IDs NCI-2015-01929
Clinicaltrials.gov ID NCT02601209