Nivolumab with or without Ipilimumab in Treating Patients with Metastatic Sarcoma That Cannot Be Removed by Surgery

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This clinical trial matches:
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Status: Active

Description

This randomized phase II trial studies how well nivolumab with or without ipilimumab works in treating patients with sarcoma that has spread from the primary site to other parts of the body or cannot be removed by surgery. Monoclonal antibodies, such as nivolumab and ipilimumab, may block tumor growth in different ways by targeting certain cells. It is not yet known whether nivolumab works better with or without ipilimumab in treating patients with metastatic or unresectable sarcoma.

Eligibility Criteria

Inclusion Criteria

  • PRE-REGISTRATION ELIGIBILITY CRITERIA:
  • Patients must have a formalin-fixed, paraffin-embedded (FFPE) tumor block OR 1 representative hematoxylin and eosin (H&E) and 20 unstained sarcoma tissue slides available for submission to central pathology review; this review is mandatory prior to registration to confirm eligibility
  • REGISTRATION ELIGIBILITY CRITERIA:
  • Patients must have histologically confirmed bone or soft tissue sarcoma by central pathology review * Patients must have histologically confirmed liposarcoma (LPS) (only dedifferentiated and pleomorphic; well differentiated not eligible), undifferentiated pleomorphic sarcoma (UPS)/malignant fibrous histiocytoma (MFH), or gastrointestinal stromal tumor (GIST)
  • Measurable disease
  • Locally advanced/unresectable or metastatic disease
  • >= 1 prior systemic therapy for sarcoma, including adjuvant systemic therapy
  • No prior therapy with ipilimumab or nivolumab, or any agent targeting programmed cell death 1 (PD-1), PD-L1 or cytotoxic T-lymphocyte-associated protein 4 (CTLA-4)
  • No treatment with biologic therapy, immunotherapy, chemotherapy, investigational agent for malignancy, or radiation =< 28 days before study registration; no treatment with nitrosourea or mitomycin =< 42 days before study registration; for GIST, tyrosine kinase inhibitor can be continued for up to 3 days prior to initiation of study treatment
  • Patients should have resolution of any toxic effects of prior therapy (except alopecia) to NCI CTCAE, version 4.0, grade 1 or less
  • No history of the following: * Active known or suspected autoimmune disease * Patients with human immunodeficiency virus (HIV) are eligible if the lymphocytes > 350 cluster of differentiation (CD)4+ cells and no detectable viral load * Symptomatic, untreated, or uncontrolled brain metastases present * Active autoimmune colitis * Autoimmune panhypopituitarism * Autoimmune adrenal insufficiency * Known active hepatitis B or C ** Hepatitis B can be defined as: *** Hepatitis B surface antigen (HBsAg) > 6 months *** Serum hepatitis B virus (HBV) deoxyribonucleic acid (DNA) 20,000 IU/ml (105 copies/ml), lower values 2,000-20,000 IU/ml (104-105 copies/ml) are often seen in hepatitis B e antigen (HBeAg)-negative chronic hepatitis B *** Persistent or intermittent elevation in alanine aminotransferase (ALT)/alanine aminotransferase (AST) levels *** Liver biopsy showing chronic hepatitis with moderate or severe necroinflammation ** Hepatitis C can be defined as: *** Hepatitis C antibody (Ab) positive *** Presence of hepatitis C virus (HCV) ribonucleic acid (RNA) * Known active pulmonary disease with hypoxia defined as: ** Oxygen saturation < 85% on room air or ** Oxygen saturation < 88% despite supplemental oxygen
  • No systemic treatment with either corticosteroids (> 10 mg daily prednisone equivalents) or other immunosuppressive medications within 14 days of registration
  • Not pregnant and not nursing; for women of childbearing potential only, a negative pregnancy test done =< 7 days prior to registration is required
  • Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1
  • Absolute neutrophil count (ANC) >= 1,500/mm^3
  • Platelet count >= 100,000/mm^3
  • Creatinine =< 1.5 x upper limit of normal (ULN) OR calculated (calc.) creatinine clearance > 45 mL/min using the lean body mass formula only
  • Total bilirubin =< 1.5 x upper limit of normal (ULN) in absence of Gilbert disease (total bilirubin =< 3 x ULN with Gilbert); also, if hyperbilirubinemia is clearly attributed to liver metastases total bilirubin =< 3 x ULN is permitted
  • AST/ALT =< 3 x upper limit of normal (ULN)
  • Thyroid stimulating hormone (TSH) within normal limits (WNL); supplementation is acceptable to achieve a TSH WNL; in patients with abnormal TSH if free T4 is normal and patient is clinically euthyroid, patient is eligible
  • Re-registration Eligibility Criteria (for patients who crossover from arm 1 nivolumab alone to dual agent nivolumab and ipilimumab upon progression)
  • Re-registration: measurable disease
  • Re-registration: locally advanced/unresectable or metastatic disease
  • Patient MUST have had progressive disease (radiographic or clinical) while on arm 1 single agent nivolumab while registered to A091401
  • Patients removed from any immunotherapy for reasons other than progressive disease, including arm 1 single agent nivolumab of A091401, are NOT eligible for re-registration
  • Patients must have completed a minimum of 10 weeks of single agent nivolumab on arm 1 of A091401 to be eligible for re-registration
  • Patients must have completed study drug on arm 1 of A091401 (i.e., last dose of nivolumab) =< 12 months of re-registration to crossover dual agent therapy
  • No treatment with immunotherapy =< 21 days before re-registration; no treatment with biologic therapy, chemotherapy, investigational agent for malignancy, or radiation =< 28 days before re-registration; no treatment with nitrosourea or mitomycin =< 42 days before re-registration
  • Patients should have resolution of any toxic effects of prior therapy (except fatigue and alopecia) to NCI CTCAE, version 4.0, grade 1 or less, including immune toxicity
  • No systemic treatment with either corticosteroids (> 10 mg daily prednisone equivalents) or other immunosuppressive medications within 14 days of re-registration
  • Not pregnant and not nursing; therefore, for women of childbearing potential only, a negative pregnancy test done =< 7 days prior to re-registration is required
  • ECOG performance status 0 or 1
  • Re-registration: ANC >= 1,500/mm^3
  • Re-registration: platelet count >= 100,000/mm^3
  • Re-registration: creatinine =< 1.5 ULN OR calc. creatinine clearance > 45 mL/min (using lean body mass formula only)
  • Re-registration: total bilirubin =< 1.5 x ULN in absence of Gilbert disease (total bilirubin =< 3 x ULN with Gilbert); if hyperbilirubinemia is clearly attributed to liver metastases, total bilirubin =< 3 x ULN is permitted
  • Re-registration: AST/ALT =< 3 x ULN
  • Re-registration: TSH WNL; supplementation is acceptable to achieve a TSH WNL; in patients with abnormal TSH, if free T4 is normal and patient is clinically euthyroid, patient is eligible

Locations & Contacts

Alaska

Anchorage
Alaska Breast Care and Surgery LLC
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Alaska Oncology and Hematology LLC
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Alaska Regional Hospital
Status: Temporarily closed to accrual
Contact: Keith S. Lanier
Phone: 907-264-2933
Alaska Women's Cancer Care
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Anchorage Associates in Radiation Medicine
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Anchorage Oncology Centre
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Anchorage Radiation Therapy Center
Status: Temporarily closed to accrual
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Katmai Oncology Group
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Providence Alaska Medical Center
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org

Arkansas

Hot Springs
CHI Saint Vincent Cancer Center Hot Springs
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org

California

Antioch
Kaiser Permanente-Deer Valley Medical Center
Status: Active
Contact: Tatjana Kolevska
Phone: 510-891-3400
Arroyo Grande
PCR Oncology
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Auburn
Sutter Auburn Faith Hospital
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Sutter Cancer Centers Radiation Oncology Services-Auburn
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Berkeley
Alta Bates Summit Medical Center-Herrick Campus
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Burbank
Providence Saint Joseph Medical Center / Disney Family Cancer Center
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Burlingame
Mills-Peninsula Medical Center
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Cameron Park
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Castro Valley
Eden Hospital Medical Center
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Davis
Sutter Davis Hospital
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Fremont
Kaiser Permanente-Fremont
Status: Active
Contact: Tatjana Kolevska
Phone: 510-891-3400
Palo Alto Medical Foundation-Fremont
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Fresno
Kaiser Permanente-Fresno
Status: Active
Contact: Tatjana Kolevska
Phone: 510-891-3400
Loma Linda
Loma Linda University Medical Center
Status: Active
Contact: Gayathri Nagaraj
Phone: 909-558-3375
Modesto
Kaiser Permanente-Modesto
Status: Active
Contact: Tatjana Kolevska
Phone: 510-891-3400
Memorial Medical Center
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Mountain View
Palo Alto Medical Foundation-Camino Division
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Palo Alto Medical Foundation-Gynecologic Oncology
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Novato
Sutter Cancer Research Consortium
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Oakland
Kaiser Permanente-Oakland
Status: Active
Contact: Tatjana Kolevska
Phone: 510-891-3400
Palo Alto
Palo Alto Medical Foundation Health Care
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Redwood City
Kaiser Permanente-Redwood City
Status: Active
Contact: Tatjana Kolevska
Phone: 510-891-3400
Richmond
Kaiser Permanente-Richmond
Status: Active
Contact: Tatjana Kolevska
Phone: 510-891-3400
Roseville
Kaiser Permanente-Roseville
Status: Active
Contact: Tatjana Kolevska
Phone: 510-891-3400
Sutter Cancer Centers Radiation Oncology Services-Roseville
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Sutter Roseville Medical Center
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Sacramento
Kaiser Permanente - Sacramento
Status: Active
Contact: Tatjana Kolevska
Phone: 510-891-3400
Kaiser Permanente Downtown Commons
Status: Active
Contact: Tatjana Kolevska
Phone: 877-642-4691
Kaiser Permanente-South Sacramento
Status: Active
Contact: Tatjana Kolevska
Phone: 510-891-3400
Sutter Medical Center Sacramento
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
San Francisco
California Pacific Medical Center-Pacific Campus
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Kaiser Permanente-San Francisco
Status: Active
Contact: Tatjana Kolevska
Phone: 510-891-3400
San Jose
Kaiser Permanente-Santa Teresa-San Jose
Status: Active
Contact: Tatjana Kolevska
Phone: 510-891-3400
San Leandro
Kaiser Permanente San Leandro
Status: Active
Contact: Tatjana Kolevska
Phone: 510-891-3400
San Rafael
Kaiser Permanente-San Rafael
Status: Active
Contact: Tatjana Kolevska
Phone: 510-891-3400
Kaiser San Rafael-Gallinas
Status: Active
Contact: Tatjana Kolevska
Phone: 707-651-2797
Santa Clara
Kaiser Permanente Medical Center - Santa Clara
Status: Active
Contact: Tatjana Kolevska
Phone: 510-891-3400
Santa Cruz
Palo Alto Medical Foundation-Santa Cruz
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Santa Rosa
Kaiser Permanente-Santa Rosa
Status: Active
Contact: Tatjana Kolevska
Phone: 510-891-3400
Sutter Pacific Medical Foundation
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
South San Francisco
Kaiser Permanente-South San Francisco
Status: Active
Contact: Tatjana Kolevska
Phone: 510-891-3400
Stockton
Kaiser Permanente-Stockton
Status: Active
Contact: Tatjana Kolevska
Phone: 510-891-3400
Sunnyvale
Palo Alto Medical Foundation-Sunnyvale
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Vacaville
Kaiser Permanente Medical Center-Vacaville
Status: Active
Contact: Tatjana Kolevska
Phone: 510-891-3400
Sutter Cancer Centers Radiation Oncology Services-Vacaville
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Vallejo
Kaiser Permanente-Vallejo
Status: Active
Contact: Tatjana Kolevska
Phone: 510-891-3400
Sutter Solano Medical Center / Cancer Center
Status: Active
Contact: Edmund Wing-To Tai
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Walnut Creek
Kaiser Permanente-Walnut Creek
Status: Active
Contact: Tatjana Kolevska
Phone: 510-891-3400

Colorado

Aurora
Rocky Mountain Cancer Centers-Aurora
Status: Active
Contact: Keren Sturtz
Phone: 303-777-2663 Email: ccrp@co-cancerresearch.org
The Medical Center of Aurora
Status: Temporarily closed to accrual
Contact: Keren Sturtz
Phone: 303-777-2663 Email: ccrp@co-cancerresearch.org
Boulder
Boulder Community Hospital
Status: Active
Contact: Keren Sturtz
Phone: 303-777-2663 Email: ccrp@co-cancerresearch.org
Rocky Mountain Cancer Centers-Boulder
Status: Active
Contact: Keren Sturtz
Phone: 303-777-2663 Email: ccrp@co-cancerresearch.org
Colorado Springs
Penrose-Saint Francis Healthcare
Status: Active
Contact: Mehmet Sitki Copur
Phone: 501-622-2100
Rocky Mountain Cancer Centers-Penrose
Status: Active
Contact: Mehmet Sitki Copur
Phone: 501-622-2100
Denver
Colorado Blood Cancer Institute
Status: Active
Contact: Keren Sturtz
Phone: 303-777-2663 Email: ccrp@co-cancerresearch.org
Colorado Cancer Research Program NCORP
Status: Temporarily closed to accrual
Contact: Keren Sturtz
Phone: 303-777-2663 Email: kgeisen@co-cancerresearch.org
Denver Health Medical Center
Status: Active
Contact: Keren Sturtz
Phone: 303-777-2663 Email: ccrp@co-cancerresearch.org
Porter Adventist Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 501-622-2100
Presbyterian - Saint Lukes Medical Center - Health One
Status: Active
Contact: Keren Sturtz
Phone: 303-777-2663 Email: ccrp@co-cancerresearch.org
Rocky Mountain Cancer Centers-Midtown
Status: Active
Contact: Keren Sturtz
Phone: 303-777-2663 Email: ccrp@co-cancerresearch.org
Rocky Mountain Cancer Centers-Rose
Status: Active
Contact: Keren Sturtz
Phone: 303-777-2663 Email: ccrp@co-cancerresearch.org
Rose Medical Center
Status: Active
Contact: Keren Sturtz
Phone: 303-777-2663 Email: ccrp@co-cancerresearch.org
The Women's Imaging Center
Status: Active
Contact: Keren Sturtz
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org
Durango
Mercy Medical Center
Status: Temporarily closed to accrual
Name Not Available
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Southwest Oncology PC
Status: Active
Name Not Available
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Englewood
Comprehensive Cancer Care and Research Institute of Colorado LLC
Status: Active
Contact: Keren Sturtz
Phone: 303-777-2663 Email: ccrp@co-cancerresearch.org
Swedish Medical Center
Status: Active
Contact: Keren Sturtz
Phone: 303-777-2663 Email: ccrp@co-cancerresearch.org
Golden
Mountain Blue Cancer Care Center
Status: Active
Contact: Mehmet Sitki Copur
Phone: 501-622-2100
National Jewish Health-Western Hematology Oncology
Status: Active
Contact: Keren Sturtz
Phone: 303-777-2663 Email: ccrp@co-cancerresearch.org
Grand Junction
Saint Mary's Hospital and Regional Medical Center
Status: Active
Contact: Keren Sturtz
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org
Greeley
North Colorado Medical Center
Status: Active
Contact: Keren Sturtz
Phone: 303-777-2663 Email: ccrp@co-cancerresearch.org
Greenwood Village
Rocky Mountain Cancer Centers-Greenwood Village
Status: Temporarily closed to accrual
Contact: Keren Sturtz
Phone: 303-777-2663 Email: ccrp@co-cancerresearch.org
Lafayette
Good Samaritan Medical Center
Status: Active
Contact: Keren Sturtz
Phone: 303-673-1622
Lakewood
Rocky Mountain Cancer Centers-Lakewood
Status: Active
Contact: Mehmet Sitki Copur
Phone: 501-622-2100
Saint Anthony Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 501-622-2100
Littleton
Littleton Adventist Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 501-622-2100
Rocky Mountain Cancer Centers-Littleton
Status: Active
Contact: Keren Sturtz
Phone: 303-777-2663 Email: ccrp@co-cancerresearch.org
Lone Tree
Rocky Mountain Cancer Centers-Sky Ridge
Status: Active
Contact: Keren Sturtz
Phone: 303-777-2663 Email: ccrp@co-cancerresearch.org
Sky Ridge Medical Center
Status: Temporarily closed to accrual
Contact: Keren Sturtz
Phone: 303-777-2663 Email: ccrp@co-cancerresearch.org
Longmont
Longmont United Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 501-622-2100
Rocky Mountain Cancer Centers-Longmont
Status: Active
Contact: Mehmet Sitki Copur
Phone: 501-622-2100
Loveland
McKee Medical Center
Status: Active
Contact: Keren Sturtz
Phone: 303-777-2663 Email: ccrp@co-cancerresearch.org
Parker
Parker Adventist Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 501-622-2100
Rocky Mountain Cancer Centers-Parker
Status: Active
Contact: Mehmet Sitki Copur
Phone: 501-622-2100
Pueblo
Rocky Mountain Cancer Centers - Pueblo
Status: Active
Contact: Mehmet Sitki Copur
Phone: 501-622-2100
Saint Mary Corwin Medical Center
Status: Active
Contact: Mehmet Sitki Copur
Phone: 501-622-2100
Thornton
Rocky Mountain Cancer Centers-Thornton
Status: Active
Contact: Mehmet Sitki Copur
Phone: 501-622-2100
Wheat Ridge
SCL Health Lutheran Medical Center
Status: Active
Contact: Keren Sturtz
Phone: 303-777-2663 Email: ccrp@co-cancerresearch.org

Connecticut

Hartford
Smilow Cancer Hospital Care Center at Saint Francis
Status: Temporarily closed to accrual
Contact: Tareq Al Baghdadi
Phone: 208-367-7954
Norwich
Eastern Connecticut Hematology and Oncology Associates
Status: Active
Contact: Dennis E. Slater
Phone: 860-886-8362

Delaware

Lewes
Beebe Medical Center
Status: Active
Contact: Gregory Andrew Masters
Phone: 302-733-6227
Newark
Christiana Care Health System-Christiana Hospital
Status: Active
Contact: Gregory Andrew Masters
Phone: 302-733-6227
Christiana Gynecologic Oncology LLC
Status: Temporarily closed to accrual
Contact: Gregory Andrew Masters
Phone: 302-733-6227
Delaware Clinical and Laboratory Physicians PA
Status: Active
Contact: Gregory Andrew Masters
Phone: 302-733-6227
Helen F Graham Cancer Center
Status: Active
Contact: Gregory Andrew Masters
Phone: 302-733-6227
Medical Oncology Hematology Consultants PA
Status: Active
Contact: Gregory Andrew Masters
Phone: 302-733-6227
Regional Hematology and Oncology PA
Status: Active
Contact: Gregory Andrew Masters
Phone: 302-733-6227
Rehoboth Beach
Beebe Health Campus
Status: Active
Contact: Gregory Andrew Masters
Phone: 302-733-6227
Seaford
Nanticoke Memorial Hospital
Status: Active
Contact: Gregory Andrew Masters
Phone: 302-733-6227
Wilmington
Christiana Care Health System-Wilmington Hospital
Status: Active
Contact: Gregory Andrew Masters
Phone: 302-733-6227

District of Columbia

Washington
MedStar Georgetown University Hospital
Status: Active
Contact: Michael Jon Pishvaian
Phone: 202-444-2223
MedStar Washington Hospital Center
Status: Active
Contact: Michael Jon Pishvaian
Phone: 202-444-2223
Sibley Memorial Hospital
Status: Active
Contact: Christian Frederick Meyer
Phone: 410-955-8804 Email: jhcccro@jhmi.edu

Florida

Aventura
Mount Sinai Comprehensive Cancer Center at Aventura
Status: Active
Contact: Michael A. Schwartz
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org
Deerfield Beach
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Status: Active
Contact: Breelyn Ann Wilky
Phone: 305-243-2647
Fort Lauderdale
Holy Cross Hospital
Status: Active
Contact: Michael A. Schwartz
Phone: 954-267-7750
Jacksonville
Baptist MD Anderson Cancer Center
Status: Active
Name Not Available
Phone: 904-202-7051
Miami
University of Miami Miller School of Medicine-Sylvester Cancer Center
Status: Active
Contact: Breelyn Ann Wilky
Phone: 305-243-2647
Miami Beach
Mount Sinai Medical Center
Status: Active
Contact: Michael A. Schwartz
Phone: 305-674-2625 Email: info@msccop.com
Plantation
UM Sylvester Comprehensive Cancer Center at Plantation
Status: Active
Contact: Breelyn Ann Wilky
Phone: 305-243-2647

Georgia

Savannah
Memorial Health University Medical Center
Status: Active
Contact: Christopher E. Haberman
Phone: 912-350-8568
Summit Cancer Care-Memorial
Status: Active
Contact: Christopher E. Haberman
Phone: 912-350-8568

Hawaii

Aiea
Hawaii Oncology Inc-Pali Momi
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979
Pali Momi Medical Center
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979
The Cancer Center of Hawaii-Pali Momi
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979
Honolulu
Hawaii Cancer Care Inc-Liliha
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979
Hawaii Cancer Care Inc-POB II
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979
Hawaii Oncology Inc-Kuakini
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979
Hawaii Oncology Inc-POB I
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979
Island Urology
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979
Kaiser Permanente Moanalua Medical Center
Status: Active
Contact: Tatjana Kolevska
Phone: 510-891-3400
Kapiolani Medical Center for Women and Children
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979
Kuakini Medical Center
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979
Queen's Medical Center
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979
Straub Clinic and Hospital
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979
The Cancer Center of Hawaii-Liliha
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979
University of Hawaii Cancer Center
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979
Lihue
Wilcox Memorial Hospital and Kauai Medical Clinic
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979

Idaho

Boise
Saint Alphonsus Cancer Care Center-Boise
Status: Active
Contact: Tareq Al Baghdadi
Phone: 208-367-7954
Saint Luke's Mountain States Tumor Institute
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Caldwell
Saint Alphonsus Cancer Care Center-Caldwell
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Coeur D'Alene
Kootenai Medical Center
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Emmett
Walter Knox Memorial Hospital
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Fruitland
Saint Luke's Mountain States Tumor Institute - Fruitland
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Meridian
Idaho Urologic Institute-Meridian
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Saint Luke's Mountain States Tumor Institute - Meridian
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Nampa
Saint Alphonsus Medical Center-Nampa
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Saint Luke's Mountain States Tumor Institute - Nampa
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Post Falls
Kootenai Cancer Center
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Sandpoint
Kootenai Cancer Clinic
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Twin Falls
Saint Luke's Mountain States Tumor Institute-Twin Falls
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org

Illinois

Aurora
Rush - Copley Medical Center
Status: Active
Contact: Yujie Zhao
Phone: 630-978-6212 Email: Cancer.Research@rushcopley.com
Bloomington
Illinois CancerCare-Bloomington
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
Canton
Illinois CancerCare-Canton
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
Carbondale
Memorial Hospital of Carbondale
Status: Active
Contact: Bryan A. Faller
Phone: 618-457-5200 Email: clinical.research@sih.net
Carterville
SIH Cancer Institute
Status: Active
Contact: Bryan A. Faller
Phone: 618-985-3333 Email: clinical.research@sih.net
Carthage
Illinois CancerCare-Carthage
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
Centralia
Centralia Oncology Clinic
Status: Active
Contact: Bryan A. Faller
Phone: 217-876-4740 Email: rhamrick@dmhhs.org
Chicago
Rush University Medical Center
Status: Active
Contact: Marta Batus
Phone: 312-942-5498 Email: clinical_trials@rush.edu
Danville
Carle on Vermilion
Status: Active
Contact: Yujie Zhao
Phone: 630-978-6212 Email: Cancer.Research@rushcopley.com
Decatur
Cancer Care Specialists of Illinois - Decatur
Status: Active
Contact: Bryan A. Faller
Phone: 217-876-4740 Email: rhamrick@dmhhs.org
Decatur Memorial Hospital
Status: Active
Contact: Bryan A. Faller
Phone: 217-876-4740 Email: rhamrick@dmhhs.org
Effingham
Carle Physician Group-Effingham
Status: Active
Contact: Yujie Zhao
Phone: 630-978-6212 Email: Cancer.Research@rushcopley.com
Crossroads Cancer Center
Status: Active
Contact: Bryan A. Faller
Phone: 217-876-4740 Email: rhamrick@dmhhs.org
Eureka
Illinois CancerCare-Eureka
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
Evanston
NorthShore University HealthSystem-Evanston Hospital
Status: Active
Contact: Bruce E. Brockstein
Phone: 847-570-2109
Galesburg
Illinois CancerCare-Galesburg
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
Western Illinois Cancer Treatment Center
Status: Active
Contact: Bryan A. Faller
Phone: 309-344-2831
Glenview
NorthShore University HealthSystem-Glenbrook Hospital
Status: Active
Contact: Bruce E. Brockstein
Phone: 847-570-2109
Highland Park
NorthShore University HealthSystem-Highland Park Hospital
Status: Active
Contact: Bruce E. Brockstein
Phone: 847-570-2109
Kewanee
Illinois CancerCare-Kewanee Clinic
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
Macomb
Illinois CancerCare-Macomb
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
Mattoon
Carle Physician Group-Mattoon / Charleston
Status: Active
Contact: Yujie Zhao
Phone: 630-978-6212 Email: Cancer.Research@rushcopley.com
Maywood
Loyola University Medical Center
Status: Active
Contact: Asha Rebecca Dhanarajan
Phone: 708-226-4357
Mount Vernon
Good Samaritan Regional Health Center
Status: Active
Contact: Jay W. Carlson
Phone: 888-221-4849
Ottawa
Illinois CancerCare-Ottawa Clinic
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
Radiation Oncology of Northern Illinois
Status: Temporarily closed to accrual
Contact: James Lloyd Wade
Phone: 309-243-3605
Pekin
Illinois CancerCare-Pekin
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
Peoria
Illinois CancerCare-Peoria
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
Methodist Medical Center of Illinois
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
OSF Saint Francis Medical Center
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
Peru
Illinois CancerCare-Peru
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
Valley Radiation Oncology
Status: Active
Contact: Bryan A. Faller
Phone: 815-664-4141
Princeton
Illinois CancerCare-Princeton
Status: Active
Contact: Bryan A. Faller
Phone: 309-243-3605 Email: andersonj@illinoiscancercare.com
Skokie
North Shore Medical Center
Status: Active
Contact: Bruce E. Brockstein
Phone: 847-570-2109
Springfield
Memorial Medical Center
Status: Active
Contact: Bryan A. Faller
Phone: 217-788-3528
Southern Illinois University School of Medicine
Status: Active
Contact: Bryan A. Faller
Phone: 217-545-7929
Springfield Clinic
Status: Active
Contact: Bryan A. Faller
Phone: 800-444-7541
Swansea
Cancer Care Specialists of Illinois-Swansea
Status: Active
Contact: Bryan A. Faller
Phone: 217-876-4740 Email: rhamrick@dmhhs.org
Southwest Illinois Health Services LLP
Status: Active
Contact: Bryan A. Faller
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org
Urbana
Carle Cancer Center
Status: Active
Contact: Yujie Zhao
Phone: 630-978-6212 Email: Cancer.Research@rushcopley.com
The Carle Foundation Hospital
Status: Active
Contact: Yujie Zhao
Phone: 630-978-6212 Email: Cancer.Research@rushcopley.com
Yorkville
Rush-Copley Healthcare Center
Status: Active
Contact: Yujie Zhao
Phone: 630-978-6212 Email: Cancer.Research@rushcopley.com

Indiana

Evansville
Deaconess Clinic Downtown
Status: Active
Contact: Yujie Zhao
Phone: 877-654-0311
Fort Wayne
Parkview Hospital Randallia
Status: Active
Contact: Zhentao Zhang
Phone: 260-373-8888 Email: parkviewresearch@parkview.com
Michigan City
Franciscan Saint Anthony Health-Michigan City
Status: Temporarily closed to accrual
Contact: Yujie Zhao
Phone: 630-978-6212 Email: Cancer.Research@rushcopley.com
Woodland Cancer Care Center
Status: Temporarily closed to accrual
Contact: Yujie Zhao
Phone: 630-978-6212 Email: Cancer.Research@rushcopley.com
Mishawaka
Memorial Regional Cancer Center Day Road
Status: Active
Contact: Thomas Joseph Reid
Phone: 800-284-7370
Newburgh
Chancellor Center for Oncology
Status: Active
Contact: Yujie Zhao
Phone: 812-426-9576
South Bend
Memorial Hospital of South Bend
Status: Active
Contact: Thomas Joseph Reid
Phone: 800-284-7370

Iowa

Ames
Mary Greeley Medical Center
Status: Active
Contact: Joseph James Merchant
Phone: 515-239-2621
McFarland Clinic PC - Ames
Status: Active
Contact: Joseph James Merchant
Phone: 515-239-2621
Boone
McFarland Clinic PC-Boone
Status: Active
Contact: Joseph James Merchant
Phone: 515-239-2621
Clive
Medical Oncology and Hematology Associates-West Des Moines
Status: Active
Contact: Mehmet Sitki Copur
Phone: 515-247-3970
Mercy Cancer Center-West Lakes
Status: Active
Contact: Mehmet Sitki Copur
Phone: 888-823-5923 Email: ctsucontact@westat.com
Council Bluffs
Alegent Health Mercy Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 888-823-5923 Email: ctsucontact@westat.com
Creston
Greater Regional Medical Center
Status: Active
Contact: Mehmet Sitki Copur
Phone: 641-782-3693 Email: KOllinger@mercydesmoines.org
Des Moines
Broadlawns Medical Center
Status: Active
Contact: Robert J. Behrens
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org
Iowa Lutheran Hospital
Status: Active
Contact: Robert J. Behrens
Phone: 515-239-2621
Iowa Methodist Medical Center
Status: Active
Contact: Robert J. Behrens
Phone: 515-239-2621
Medical Oncology and Hematology Associates-Des Moines
Status: Active
Contact: Robert J. Behrens
Phone: 515-239-2621
Medical Oncology and Hematology Associates-Laurel
Status: Active
Contact: Mehmet Sitki Copur
Phone: 515-247-3970
Mercy Medical Center - Des Moines
Status: Active
Contact: Mehmet Sitki Copur
Phone: 888-221-4849
Fort Dodge
McFarland Clinic PC-Trinity Cancer Center
Status: Active
Contact: Joseph James Merchant
Phone: 515-239-2621
Trinity Regional Medical Center
Status: Active
Name Not Available
Phone: 515-574-8302
Iowa City
University of Iowa / Holden Comprehensive Cancer Center
Status: Active
Contact: Mohammed M. Milhem
Phone: 800-237-1225
Jefferson
McFarland Clinic PC-Jefferson
Status: Active
Contact: Joseph James Merchant
Phone: 515-239-2621
Marshalltown
McFarland Clinic PC-Marshalltown
Status: Active
Contact: Joseph James Merchant
Phone: 515-239-2621
West Des Moines
Mercy Medical Center-West Lakes
Status: Active
Contact: Mehmet Sitki Copur
Phone: 888-823-5923 Email: ctsucontact@westat.com
Methodist West Hospital
Status: Active
Contact: Robert J. Behrens
Phone: 515-239-2621

Kansas

Chanute
Cancer Center of Kansas - Chanute
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Dodge City
Cancer Center of Kansas - Dodge City
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
El Dorado
Cancer Center of Kansas - El Dorado
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Fort Scott
Cancer Center of Kansas - Fort Scott
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Garden City
Central Care Cancer Center - Garden City
Status: Active
Contact: Rakesh Gaur
Phone: 913-948-5588 Email: aroland@kccop.org
Great Bend
Central Care Cancer Center - Great Bend
Status: Active
Contact: Rakesh Gaur
Phone: 913-948-5588 Email: aroland@kccop.org
Independence
Cancer Center of Kansas-Independence
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Kingman
Cancer Center of Kansas-Kingman
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Lawrence
Lawrence Memorial Hospital
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Lenexa
Kansas Institute of Medicine Cancer and Blood Center
Status: Active
Contact: Rakesh Gaur
Phone: 913-948-5588 Email: aroland@kccop.org
Minimally Invasive Surgery Hospital
Status: Active
Contact: Rakesh Gaur
Phone: 913-948-5588 Email: aroland@kccop.org
Liberal
Cancer Center of Kansas-Liberal
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Manhattan
Cancer Center of Kansas-Manhattan
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5784
McPherson
Cancer Center of Kansas - McPherson
Status: Active
Contact: Shaker R. Dakhil
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org
Newton
Cancer Center of Kansas - Newton
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Overland Park
Menorah Medical Center
Status: Active
Contact: Rakesh Gaur
Phone: 913-948-5588 Email: aroland@kccop.org
Parsons
Cancer Center of Kansas - Parsons
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Pratt
Cancer Center of Kansas - Pratt
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Salina
Cancer Center of Kansas - Salina
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Wellington
Cancer Center of Kansas - Wellington
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Wichita
Associates In Womens Health
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Cancer Center of Kansas - Wichita
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Cancer Center of Kansas-Wichita Medical Arts Tower
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Via Christi Regional Medical Center
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Winfield
Cancer Center of Kansas - Winfield
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374

Kentucky

Bardstown
Flaget Memorial Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 502-350-5700
Corbin
Commonwealth Cancer Center-Corbin
Status: Active
Contact: Mehmet Sitki Copur
Phone: 888-823-5923 Email: ctsucontact@westat.com
Lexington
Saint Joseph Hospital East
Status: Active
Contact: Mehmet Sitki Copur
Phone: 859-967-5107
Saint Joseph Radiation Oncology Resource Center
Status: Active
Contact: Mehmet Sitki Copur
Phone: 859-277-3737 Email: hollinaw@sjhlex.org
London
Saint Joseph London
Status: Active
Contact: Mehmet Sitki Copur
Phone: 888-823-5923 Email: ctsucontact@westat.com
Louisville
Jewish Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 502-587-4103
Jewish Hospital Medical Center Northeast
Status: Active
Contact: Mehmet Sitki Copur
Phone: 502-210-4200
Saints Mary and Elizabeth Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 502-587-4108
Shepherdsville
Jewish Hospital Medical Center South
Status: Active
Contact: Mehmet Sitki Copur
Phone: 888-823-5923 Email: ctsucontact@westat.com

Louisiana

Baton Rouge
Medical Center of Baton Rouge
Status: Active
Contact: Marc R. Matrana
Phone: 225-761-5346 Email: Camille.Beck@Ochsner.org
Ochsner Health Center-Summa
Status: Active
Contact: Marc R. Matrana
Phone: 504-842-3708
Kenner
Ochsner Medical Center Kenner
Status: Active
Contact: Marc R. Matrana
Phone: 504-842-3708
New Orleans
Ochsner Medical Center Jefferson
Status: Active
Contact: Marc R. Matrana
Phone: 504-842-3708

Maryland

Baltimore
Johns Hopkins University / Sidney Kimmel Cancer Center
Status: Active
Contact: Christian Frederick Meyer
Phone: 410-955-8804 Email: jhcccro@jhmi.edu
MedStar Franklin Square Medical Center / Weinberg Cancer Institute
Status: Active
Contact: Michael Jon Pishvaian
Phone: 202-444-2223

Massachusetts

Boston
Dana-Farber Cancer Institute
Status: Active
Contact: Michael Jason Nathenson
Phone: 877-442-3324
Massachusetts General Hospital Cancer Center
Status: Active
Contact: Michael Jason Nathenson
Phone: 877-726-5130

Michigan

Ann Arbor
Saint Joseph Mercy Hospital
Status: Active
Contact: Tareq Al Baghdadi
Phone: 208-367-7954
University of Michigan Comprehensive Cancer Center
Status: Active
Contact: Scott Michael Schuetze
Phone: 800-865-1125
Brighton
IHA Hematology Oncology Consultants-Brighton
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Saint Joseph Mercy Brighton
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Canton
IHA Hematology Oncology Consultants-Canton
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Saint Joseph Mercy Canton
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Caro
Caro Cancer Center
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Chelsea
IHA Hematology Oncology Consultants-Chelsea
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Saint Joseph Mercy Chelsea
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Clarkston
Hematology Oncology Consultants-Clarkston
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Newland Medical Associates-Clarkston
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Dearborn
Beaumont Hospital-Dearborn
Status: Temporarily closed to accrual
Contact: Tareq Al Baghdadi
Phone: 248-551-7695
Detroit
Saint John Hospital and Medical Center
Status: Active
Contact: Tareq Al Baghdadi
Phone: 208-367-7954
East China
Great Lakes Cancer Management Specialists-Doctors Park
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Flint
Genesee Cancer and Blood Disease Treatment Center
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Genesee Hematology Oncology PC
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Genesys Hurley Cancer Institute
Status: Active
Contact: Tareq Al Baghdadi
Phone: 208-367-7954
Hurley Medical Center
Status: Active
Contact: Tareq Al Baghdadi
Phone: 208-367-7954
Gorsse Pointe Woods
Lymphoma Clinic of Michigan
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Grosse Pointe Woods
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Michigan Breast Specialists-Grosse Pointe Woods
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Jackson
Allegiance Health
Status: Temporarily closed to accrual
Contact: Tareq Al Baghdadi
Phone: 517-788-4800
Lansing
Sparrow Hospital
Status: Active
Contact: Tareq Al Baghdadi
Phone: 208-367-7954
Livonia
Hope Cancer Clinic
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Saint Mary Mercy Hospital
Status: Active
Contact: Tareq Al Baghdadi
Phone: 208-367-7954
Macomb Township
Great Lakes Cancer Management Specialists-Macomb Medical Campus
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Michigan Breast Specialists-Macomb Township
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Marlette
Saint Mary's Oncology / Hematology Associates of Marlette
Status: Active
Contact: Tareq Al Baghdadi
Phone: 989-343-2487
Pontiac
21st Century Oncology-Pontiac
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Hope Cancer Center
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Newland Medical Associates-Pontiac
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Saint Joseph Mercy Oakland
Status: Active
Contact: Tareq Al Baghdadi
Phone: 208-367-7954
Port Huron
Huron Medical Center PC
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Lake Huron Medical Center
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Rochester Hills
Great Lakes Cancer Management Specialists-Rochester Hills
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Saginaw
Oncology Hematology Associates of Saginaw Valley PC
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Saint Mary's of Michigan
Status: Active
Contact: Tareq Al Baghdadi
Phone: 208-367-7954
Sterling Heights
Bhadresh Nayak MD PC-Sterling Heights
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Tawas City
Saint Joseph Health System-Tawas City
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Warren
Advanced Breast Care Center PLLC
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Bhadresh Nayak MD PC-Warren
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Great Lakes Cancer Management Specialists-Macomb Professional Building
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Macomb Hematology Oncology PC
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Michigan Breast Specialists-Warren
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Saint John Macomb-Oakland Hospital
Status: Active
Contact: Tareq Al Baghdadi
Phone: 208-367-7954
West Branch
Saint Mary's Oncology / Hematology Associates of West Branch
Status: Active
Contact: Tareq Al Baghdadi
Phone: 989-343-2487
Ypsilanti
Huron Gastroenterology PC
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
IHA Hematology Oncology Consultants-Ann Arbor
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671

Minnesota

Bemidji
Sanford Clinic North-Bemidgi
Status: Active
Contact: Preston D. Steen
Phone: 712-252-0088
Brainerd
Essentia Health Saint Joseph's Medical Center
Status: Active
Contact: Bret E.B. Friday
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org
Burnsville
Fairview Ridges Hospital
Status: Active
Contact: Daniel M. Anderson
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Coon Rapids
Mercy Hospital
Status: Active
Contact: Daniel M. Anderson
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Deer River
Essentia Health - Deer River Clinic
Status: Active
Name Not Available
Phone: 218-786-3308
Detroit Lakes
Essentia Health Saint Mary's - Detroit Lakes Clinic
Status: Active
Name Not Available
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org
Duluth
Essentia Health Cancer Center
Status: Active
Contact: Bret E.B. Friday
Phone: 218-786-3308
Essentia Health Saint Mary's Medical Center
Status: Active
Contact: Bret E.B. Friday
Phone: 888-203-7267
Miller-Dwan Hospital
Status: Active
Contact: Bret E.B. Friday
Phone: 888-203-7267
Edina
Fairview-Southdale Hospital
Status: Active
Contact: Daniel M. Anderson
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Fergus Falls
Lake Region Healthcare Corporation-Cancer Care
Status: Active
Contact: Bret E.B. Friday
Phone: 218-736-8688
Fosston
Essentia Health - Fosston
Status: Active
Name Not Available
Phone: 701-364-6272
Fridley
Unity Hospital
Status: Active
Contact: Daniel M. Anderson
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Hibbing
Essentia Health Hibbing Clinic
Status: Active
Contact: Bret E.B. Friday
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org
Maple Grove
Fairview Maple Grove Medical Center
Status: Active
Contact: Daniel M. Anderson
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Maplewood
Minnesota Oncology Hematology PA-Maplewood
Status: Active
Contact: Daniel M. Anderson
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Saint John's Hospital - Healtheast
Status: Active
Contact: Daniel M. Anderson
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Minneapolis
Abbott-Northwestern Hospital
Status: Active
Contact: Daniel M. Anderson
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Health Partners Inc
Status: Active
Contact: Daniel M. Anderson
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Hennepin County Medical Center
Status: Active
Contact: Daniel M. Anderson
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
New Ulm
New Ulm Medical Center
Status: Active
Contact: Daniel M. Anderson
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Park Rapids
Essentia Health - Park Rapids
Status: Active
Name Not Available
Phone: 701-364-6272
Robbinsdale
North Memorial Medical Health Center
Status: Active
Contact: Daniel M. Anderson
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Saint Louis Park
Park Nicollet Clinic - Saint Louis Park
Status: Active
Contact: Daniel M. Anderson
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Saint Paul
Regions Hospital
Status: Active
Contact: Daniel M. Anderson
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
United Hospital
Status: Active
Contact: Daniel M. Anderson
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Sandstone
Essentia Health Sandstone
Status: Active
Name Not Available
Phone: 701-364-6272
Shakopee
Saint Francis Regional Medical Center
Status: Active
Contact: Daniel M. Anderson
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Stillwater
Lakeview Hospital
Status: Active
Contact: Daniel M. Anderson
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Virginia
Essentia Health Virginia Clinic
Status: Active
Contact: Bret E.B. Friday
Phone: 844-681-7944
Waconia
Ridgeview Medical Center
Status: Active
Contact: Daniel M. Anderson
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Willmar
Rice Memorial Hospital
Status: Active
Contact: Daniel M. Anderson
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Woodbury
Minnesota Oncology Hematology PA-Woodbury
Status: Active
Contact: Daniel M. Anderson
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Wyoming
Fairview Lakes Medical Center
Status: Active
Contact: Daniel M. Anderson
Phone: 952-993-1517 Email: mmcorc@healthpartners.com

Missouri

Bolivar
Central Care Cancer Center - Bolivar
Status: Active
Contact: Rakesh Gaur
Phone: 913-948-5588 Email: aroland@kccop.org
Bonne Terre
Parkland Health Center-Bonne Terre
Status: Active
Contact: Bryan A. Faller
Phone: 314-996-5569
Branson
Cox Cancer Center Branson
Status: Active
Contact: Jay W. Carlson
Phone: 888-221-4849
Cape Girardeau
Saint Francis Medical Center
Status: Active
Contact: Bryan A. Faller
Phone: 573-334-2230 Email: sfmc@sfmc.net
Southeast Cancer Center
Status: Active
Contact: Bryan A. Faller
Phone: 573-651-5550
Chesterfield
Saint Luke's Hospital
Status: Active
Contact: Donald F. Busiek
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org
Independence
Centerpoint Medical Center LLC
Status: Active
Contact: Rakesh Gaur
Phone: 913-948-5588 Email: aroland@kccop.org
Jefferson City
Capital Region Southwest Campus
Status: Active
Contact: Bryan A. Faller
Phone: 573-632-4814 Email: swooden@mail.crmc.org
Joplin
Freeman Health System
Status: Active
Contact: Jay W. Carlson
Phone: 888-221-4849
Mercy Hospital Joplin
Status: Active
Contact: Jay W. Carlson
Phone: 888-221-4849
Kansas City
Research Medical Center
Status: Active
Contact: Rakesh Gaur
Phone: 913-948-5588 Email: aroland@kccop.org
Rolla
Delbert Day Cancer Institute at PCRMC
Status: Active
Contact: Jay W. Carlson
Phone: 888-221-4849
Mercy Clinic-Rolla-Cancer and Hematology
Status: Active
Contact: Jay W. Carlson
Phone: 888-221-4849
Saint Joseph
Heartland Regional Medical Center
Status: Active
Contact: Jay W. Carlson
Phone: 913-948-5588 Email: aroland@kccop.org
Saint Louis
Mercy Hospital Saint Louis
Status: Active
Contact: Jay W. Carlson
Phone: 888-221-4849
Missouri Baptist Medical Center
Status: Active
Contact: Bryan A. Faller
Phone: 314-996-5569
Saint Louis Cancer and Breast Institute-South City
Status: Active
Contact: Jay W. Carlson
Phone: 888-221-4849
Siteman Cancer Center-South County
Status: Active
Contact: Brian Andrew Van Tine
Phone: 800-600-3606 Email: info@siteman.wustl.edu
Washington University School of Medicine
Status: Active
Contact: Brian Andrew Van Tine
Phone: 800-600-3606 Email: info@siteman.wustl.edu
Sainte Genevieve
Sainte Genevieve County Memorial Hospital
Status: Active
Contact: Bryan A. Faller
Phone: 314-996-5569
Springfield
CoxHealth South Hospital
Status: Active
Contact: Jay W. Carlson
Phone: 888-221-4849
Mercy Hospital Springfield
Status: Active
Contact: Jay W. Carlson
Phone: 888-221-4849
Sullivan
Missouri Baptist Sullivan Hospital
Status: Active
Contact: Bryan A. Faller
Phone: 314-996-5569
Sunset Hills
Missouri Baptist Outpatient Center-Sunset Hills
Status: Active
Contact: Bryan A. Faller
Phone: 314-996-5569

Montana

Billings
Billings Clinic Cancer Center
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Saint Vincent Frontier Cancer Center
Status: Active
Contact: Keren Sturtz
Phone: 800-648-6274
Saint Vincent Healthcare
Status: Active
Contact: Keren Sturtz
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Bozeman
Bozeman Deaconess Hospital
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Great Falls
Benefis Healthcare- Sletten Cancer Institute
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Helena
Saint Peter's Community Hospital
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Kalispell
Kalispell Regional Medical Center
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Missoula
Community Medical Hospital
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Saint Patrick Hospital - Community Hospital
Status: Temporarily closed to accrual
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org

Nebraska

Grand Island
CHI Health Saint Francis
Status: Active
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Kearney
CHI Health Good Samaritan
Status: Active
Contact: Mehmet Sitki Copur
Phone: 888-823-5923 Email: ctsucontact@westat.com
Heartland Hematology and Oncology
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-865-2303
Lincoln
Saint Elizabeth Regional Medical Center
Status: Active
Contact: Mehmet Sitki Copur
Phone: 402-483-2827
Omaha
Alegent Health Bergan Mercy Medical Center
Status: Active
Contact: Mehmet Sitki Copur
Phone: 402-398-6060
Alegent Health Immanuel Medical Center
Status: Active
Contact: Mehmet Sitki Copur
Phone: 402-343-8511 Email: research@alegent.org
Alegent Health Lakeside Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 888-823-5923 Email: ctsucontact@westat.com
Creighton University Medical Center
Status: Active
Contact: Mehmet Sitki Copur
Phone: 402-280-4100
Hematology and Oncology Consultants PC
Status: Active
Contact: Mehmet Sitki Copur
Phone: 402-572-3535
Nebraska Methodist Hospital
Status: Active
Contact: Kirsten M. Hotton Leu
Phone: 402-991-8070 Email: mwilwerding@canceralliance-ne.org
Papillion
Midlands Community Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 800-253-4638

Nevada

Carson City
Carson Tahoe Regional Medical Center
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Henderson
21st Century Oncology-Henderson
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Cancer and Blood Specialists-Henderson
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Comprehensive Cancer Centers of Nevada - Henderson
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Comprehensive Cancer Centers of Nevada-Horizon Ridge
Status: Active
Contact: John Allan Ellerton
Phone: 702-822-2000
Comprehensive Cancer Centers of Nevada-Southeast Henderson
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Las Vegas Cancer Center-Henderson
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Nevada Cancer Specialists-Saint Rose
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Las Vegas
21st Century Oncology
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
21st Century Oncology-Fort Apache
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
21st Century Oncology-Vegas Tenaya
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Ann M Wierman MD LTD
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Cancer and Blood Specialists-Shadow
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Cancer and Blood Specialists-Tenaya
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Cancer Therapy and Integrative Medicine
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Comprehensive Cancer Centers of Nevada
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Comprehensive Cancer Centers of Nevada - Central Valley
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Comprehensive Cancer Centers of Nevada - Northwest
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Comprehensive Cancer Centers of Nevada-Summerlin
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Desert West Surgery
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
HealthCare Partners Medical Group Oncology / Hematology-Centennial Hills
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
HealthCare Partners Medical Group Oncology / Hematology-Maryland Parkway
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
HealthCare Partners Medical Group Oncology / Hematology-San Martin
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
HealthCare Partners Medical Group Oncology / Hematology-Tenaya
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Las Vegas Cancer Center-Medical Center
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Nevada Cancer Specialists?Oakey
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Nevada Cancer Specialists-Fort Apache
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Nevada Cancer Specialists-Tenaya
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Radiation Oncology Centers of Nevada Central
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Radiation Oncology Centers of Nevada Southeast
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Summerlin Hospital Medical Center
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
University Cancer Center
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
University Medical Center of Southern Nevada
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Pahrump
Hope Cancer Care of Nevada-Pahrump
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Reno
Radiation Oncology Associates
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Renown Regional Medical Center
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Saint Mary's Regional Medical Center
Status: Active
Contact: John Allan Ellerton
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org

New Jersey

Brick
Ocean Medical Center
Status: Active
Contact: Denis B. Fitzgerald
Phone: 732-206-8384
Camden
Cooper Hospital University Medical Center
Status: Active
Contact: Nati Lerman
Phone: 856-325-6757
Hackensack
Hackensack University Medical Center
Status: Active
Contact: Samuel A. Goldlust
Phone: 201-996-2879
Holmdel
Bayshore Community Hospital
Status: Active
Contact: Denis B. Fitzgerald
Phone: 888-823-5923 Email: ctsucontact@westat.com
Manahawkin
Southern Ocean County Medical Center
Status: Active
Contact: Denis B. Fitzgerald
Phone: 609-978-3429
Mount Laurel
Cooper CyberKnife Center
Status: Active
Contact: Nati Lerman
Phone: 856-325-6757
Neptune
Jersey Shore Medical Center
Status: Active
Contact: Denis B. Fitzgerald
Phone: 732-776-4240
Red Bank
Riverview Medical Center / Booker Cancer Center
Status: Active
Contact: Denis B. Fitzgerald
Phone: 732-530-2382
Voorhees
MD Anderson Cancer Center at Cooper-Voorhees
Status: Active
Contact: Nati Lerman
Phone: 856-325-6757

New Mexico

Albuquerque
New Mexico Oncology Hematology Consultants
Status: Active
Contact: Ian Rabinowitz
Phone: 505-272-0530 Email: CLee@nmcca.org
University of New Mexico Cancer Center
Status: Active
Contact: Ian Rabinowitz
Phone: 505-925-0366 Email: LByatt@nmcca.org
Las Cruces
Memorial Medical Center - Las Cruces
Status: Active
Contact: Ian Rabinowitz
Phone: 575-556-6545 Email: Kim.Hoffman@lpnt.net

New York

New York
Columbia University / Herbert Irving Cancer Center
Status: Active
Contact: Gary K. Schwartz
Phone: 212-639-7202
Memorial Sloan Kettering Cancer Center
Status: Active
Contact: Sandra Pierina D'Angelo
Phone: 212-639-7202
Syracuse
State University of New York Upstate Medical University
Status: Active
Contact: Rahul Seth
Phone: 315-464-5476

North Carolina

Asheville
Asheville Hematology-Oncology Associates
Status: Active
Contact: Raymond Thertulien
Phone: 919-781-7070
Clinton
Southeastern Medical Oncology Center-Clinton
Status: Active
Contact: James N. Atkins
Phone: 252-399-7491
Clyde
Haywood Infusion Center
Status: Active
Contact: Raymond Thertulien
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org
Goldsboro
Southeastern Medical Oncology Center-Goldsboro
Status: Active
Contact: James N. Atkins
Phone: 252-399-7491
Wayne Memorial Hospital
Status: Active
Contact: James N. Atkins
Phone: 252-399-7491
Hendersonville
Hendersonville Hematology and Oncology at Pardee
Status: Temporarily closed to accrual
Contact: James Earl Radford
Phone: 828-696-4716
Margaret R Pardee Memorial Hospital
Status: Active
Contact: James Earl Radford
Phone: 828-696-1341
Park Ridge Health
Status: Active
Contact: Raymond Thertulien
Phone: 855-774-5433
Jacksonville
Onslow Memorial Hospital
Status: Active
Contact: James N. Atkins
Phone: 252-399-7491
Southeastern Medical Oncology Center-Jacksonville
Status: Active
Contact: James N. Atkins
Phone: 252-399-7491
Kinston
Vidant Oncology-Kinston
Status: Active
Name Not Available
Phone: 252-559-2201 Email: Carla.Zimmerman@vidanthealth.com
Wilson
Southeastern Medical Oncology Center-Wilson
Status: Temporarily closed to accrual
Contact: James N. Atkins
Phone: 800-849-0203

North Dakota

Bismarck
Sanford Bismarck Medical Center
Status: Active
Contact: Preston D. Steen
Phone: 712-252-0088
Fargo
Essentia Health Cancer Center-South University Clinic
Status: Active
Contact: Bret E.B. Friday
Phone: 800-437-4054
Roger Maris Cancer Center
Status: Active
Contact: Preston D. Steen
Phone: 712-252-0088
Sanford Broadway Medical Center
Status: Active
Contact: Preston D. Steen
Phone: 712-252-0088
Sanford Clinic North-Fargo
Status: Temporarily closed to accrual
Contact: Preston D. Steen
Phone: 712-252-0088
Jamestown
Essentia Health - Jamestown Clinic
Status: Active
Name Not Available
Phone: 701-364-6272

Ohio

Beachwood
UHHS-Chagrin Highlands Medical Center
Status: Active
Contact: Henry B. Koon
Phone: 216-844-1374
Chardon
Geauga Hospital
Status: Active
Contact: Henry B. Koon
Phone: 888-823-5923 Email: ctsucontact@westat.com
Cincinnati
Bethesda North Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 513-862-2230
Good Samaritan Hospital - Cincinnati
Status: Active
Contact: Mehmet Sitki Copur
Phone: 513-862-2230
TriHealth Cancer Institute-Anderson
Status: Active
Contact: Mehmet Sitki Copur
Phone: 513-451-4033
TriHealth Cancer Institute-Westside
Status: Active
Contact: Mehmet Sitki Copur
Phone: 513-451-4033 Email: lisa_wittwer@trihealth.com
Cleveland
Case Western Reserve University
Status: Active
Contact: Henry B. Koon
Phone: 800-641-2422
Columbus
Ohio State University Comprehensive Cancer Center
Status: Active
Contact: James Lin Chen
Phone: 800-293-5066 Email: Jamesline@osumc.edu
Elyria
Hematology Oncology Center Incorporated
Status: Temporarily closed to accrual
Contact: Henry B. Koon
Phone: 888-823-5923 Email: ctsucontact@westat.com
Mercy Cancer Center-Elyria
Status: Active
Contact: Henry B. Koon
Phone: 800-641-2422 Email: CTUReferral@UHhospitals.org
Mayfield Heights
Ireland Cancer Center Landerbrook Health Center
Status: Active
Contact: Henry B. Koon
Phone: 888-823-5923 Email: ctsucontact@westat.com
Mentor
Lake University Ireland Cancer Center
Status: Active
Contact: Henry B. Koon
Phone: 440-205-5491
Middleburg Heights
Southwest General Health Center Ireland Cancer Center
Status: Active
Contact: Henry B. Koon
Phone: 440-816-5050
Parma
University Hospitals Parma Medical Center
Status: Active
Contact: Henry B. Koon
Phone: 440-743-4747
Sandusky
Ireland Cancer Center at Firelands Regional Medical Center
Status: Active
Contact: Henry B. Koon
Phone: 888-823-5923 Email: ctsucontact@westat.com
Wadsworth
University Hospitals Sharon Health Center
Status: Active
Contact: Henry B. Koon
Phone: 888-823-5923 Email: ctsucontact@westat.com
Westlake
UH Seidman Cancer Center at Saint John Medical Center
Status: Active
Contact: Henry B. Koon
Phone: 888-823-5923 Email: ctsucontact@westat.com
UHHS-Westlake Medical Center
Status: Active
Contact: Henry B. Koon
Phone: 216-844-1374

Oklahoma

Oklahoma City
Mercy Hospital Oklahoma City
Status: Active
Contact: Jay W. Carlson
Phone: 405-751-4343

Oregon

Baker City
Saint Alphonsus Medical Center-Baker City
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Bend
Saint Charles Health System
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Clackamas
Clackamas Radiation Oncology Center
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Providence Oncology and Hematology Care Southeast
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Coos Bay
Bay Area Hospital
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Newberg
Providence Newberg Medical Center
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Ontario
Saint Alphonsus Medical Center-Ontario
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Oregon City
Providence Willamette Falls Medical Center
Status: Temporarily closed to accrual
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Portland
Kaiser Permanente Northwest
Status: Active
Contact: Abdul Hai Mansoor
Phone: 503-335-2400
Providence Portland Medical Center
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Providence Saint Vincent Medical Center
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Redmond
Saint Charles Health System-Redmond
Status: Active
Contact: Alison Katherine Conlin
Phone: 541-706-2909

Pennsylvania

Allentown
Lehigh Valley Hospital-Cedar Crest
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Bethlehem
Lehigh Valley Hospital - Muhlenberg
Status: Active
Contact: Tareq Al Baghdadi
Phone: 734-712-3671
Chadds Ford
Christiana Care Health System-Concord Health Center
Status: Active
Contact: Gregory Andrew Masters
Phone: 302-733-6227
Danville
Geisinger Medical Center
Status: Active
Contact: Joseph Joe Lukose Vadakara
Phone: 570-271-5251
Hazleton
Geisinger Medical Center-Cancer Center Hazleton
Status: Active
Contact: Joseph Joe Lukose Vadakara
Phone: 570-271-5251
Lewisburg
Geisinger Medical Oncology-Lewisburg
Status: Active
Contact: Joseph Joe Lukose Vadakara
Phone: 570-271-5251
Lewistown
Lewistown Hospital
Status: Active
Contact: Joseph Joe Lukose Vadakara
Phone: 570-271-5251
Philadelphia
Thomas Jefferson University Hospital
Status: Active
Contact: Atrayee Basu Mallick
Phone: 215-955-8874 Email: Atrayee.basumallick@jefferson.edu
Pottsville
Geisinger Cancer Services-Pottsville
Status: Active
Contact: Joseph Joe Lukose Vadakara
Phone: 570-271-5251
Scranton
Community Medical Center
Status: Active
Contact: Joseph Joe Lukose Vadakara
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org
Selinsgrove
Geisinger Medical Oncology-Selinsgrove
Status: Active
Contact: Joseph Joe Lukose Vadakara
Phone: 570-374-8555
State College
Geisinger Medical Group
Status: Active
Contact: Joseph Joe Lukose Vadakara
Phone: 570-271-5251
Wilkes-Barre
Geisinger Wyoming Valley / Henry Cancer Center
Status: Active
Contact: Joseph Joe Lukose Vadakara
Phone: 570-271-5251

South Carolina

Charleston
Medical University of South Carolina
Status: Active
Contact: Daniel Y. Reuben
Phone: 843-792-9321
Easley
Greenville Health System Cancer Institute-Easley
Status: Active
Contact: Jeffrey Kent Giguere
Phone: 864-679-3966
Greenville
Greenville Health System Cancer Institute-Butternut
Status: Active
Contact: Jeffrey Kent Giguere
Phone: 864-679-3966
Greenville Health System Cancer Institute-Eastside
Status: Active
Contact: Jeffrey Kent Giguere
Phone: 864-679-3966
Greenville Health System Cancer Institute-Faris
Status: Active
Contact: Jeffrey Kent Giguere
Phone: 864-679-3966
Greenville Memorial Hospital
Status: Active
Contact: Jeffrey Kent Giguere
Phone: 864-679-3966
Saint Francis Cancer Center
Status: Active
Contact: Robert D. Siegel
Phone: 864-255-1713
Saint Francis Hospital
Status: Active
Contact: Robert D. Siegel
Phone: 864-255-1713
Greer
Greenville Health System Cancer Institute-Greer
Status: Active
Contact: Jeffrey Kent Giguere
Phone: 864-679-3966
Seneca
Greenville Health System Cancer Institute-Seneca
Status: Active
Contact: Jeffrey Kent Giguere
Phone: 864-679-3966
Spartanburg
Greenville Health System Cancer Institute-Spartanburg
Status: Active
Contact: Jeffrey Kent Giguere
Phone: 864-679-3966

South Dakota

Sioux Falls
Sanford Cancer Center Oncology Clinic
Status: Active
Contact: Preston D. Steen
Phone: 712-252-0088
Sanford USD Medical Center - Sioux Falls
Status: Active
Contact: Preston D. Steen
Phone: 712-252-0088

Tennessee

Chattanooga
Memorial Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 423-495-7730
Hixson
Pulmonary Medicine Center of Chattanooga-Hixson
Status: Active
Contact: Mehmet Sitki Copur
Phone: 888-823-5923 Email: ctsucontact@westat.com
Ooltewah
Memorial GYN Plus
Status: Active
Contact: Mehmet Sitki Copur
Phone: 888-823-5923 Email: ctsucontact@westat.com

Texas

Bryan
Saint Joseph Regional Cancer Center
Status: Active
Contact: Mehmet Sitki Copur
Phone: 979-774-0808

Washington

Aberdeen
Providence Regional Cancer System-Aberdeen
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Anacortes
Cancer Care Center at Island Hospital
Status: Temporarily closed to accrual
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Bellevue
Swedish Cancer Institute-Eastside Oncology Hematology
Status: Temporarily closed to accrual
Contact: Keith S. Lanier
Phone: 888-823-5923 Email: ctsucontact@westat.com
Bellingham
PeaceHealth Saint Joseph Medical Center
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Bremerton
Harrison HealthPartners Hematology and Oncology-Bremerton
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Harrison Medical Center
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Burien
Highline Medical Center-Main Campus
Status: Active
Name Not Available
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Centralia
Providence Regional Cancer System-Centralia
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Edmonds
Swedish Medical Center-Edmonds
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Enumclaw
Saint Elizabeth Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 888-823-5923 Email: ctsucontact@westat.com
Everett
Providence Regional Cancer Partnership
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Federal Way
Saint Francis Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 253-944-8100
Issaquah
Swedish Cancer Institute-Issaquah
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Kennewick
Kadlec Clinic Hematology and Oncology
Status: Active
Contact: Alison Katherine Conlin
Phone: 509-783-4637 Email: research@cbho.org
Lacey
Providence Regional Cancer System-Lacey
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Lakewood
Saint Clare Hospital
Status: Active
Contact: Mehmet Sitki Copur
Phone: 253-985-6110
Longview
PeaceHealth Saint John Medical Center
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Poulsbo
Harrison HealthPartners Hematology and Oncology-Poulsbo
Status: Active
Contact: Mehmet Sitki Copur
Phone: 308-398-6518 Email: clinicaltrials@sfmc-gi.org
Seattle
Kaiser Permanente Washington
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Minor and James Medical PLLC
Status: Temporarily closed to accrual
Contact: Keith S. Lanier
Phone: 206-386-9501
Pacific Gynecology Specialists
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Swedish Medical Center-Ballard Campus
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Swedish Medical Center-Cherry Hill
Status: Active
Contact: Alison Katherine Conlin
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org
Swedish Medical Center-First Hill
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Sedro-Woolley
PeaceHealth United General Medical Center
Status: Active
Contact: Alison Katherine Conlin
Phone: 360-788-8240
Shelton
Providence Regional Cancer System-Shelton
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Spokane
Evergreen Hematology and Oncology PS
Status: Temporarily closed to accrual
Contact: Keith S. Lanier
Phone: 888-823-5923 Email: ctsucontact@westat.com
Rockwood Cancer Treatment Center-DHEC-Downtown
Status: Temporarily closed to accrual
Contact: Alison Katherine Conlin
Phone: 509-724-4454 Email: apope@rockwoodclinic.com
Rockwood North Cancer Treatment Center
Status: Temporarily closed to accrual
Contact: Alison Katherine Conlin
Phone: 509-724-4454 Email: apope@rockwoodclinic.com
Spokane Valley
Rockwood Clinic Cancer Treatment Center-Valley
Status: Temporarily closed to accrual
Contact: Alison Katherine Conlin
Phone: 509-724-4454 Email: apope@rockwoodclinic.com
Tacoma
Franciscan Research Center-Northwest Medical Plaza
Status: Active
Contact: Mehmet Sitki Copur
Phone: 888-823-5923 Email: ctsucontact@westat.com
Northwest Medical Specialties PLLC
Status: Active
Contact: Mehmet Sitki Copur
Phone: 253-428-8750
Vancouver
PeaceHealth Southwest Medical Center
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Walla Walla
Providence Saint Mary Regional Cancer Center
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org
Yakima
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Status: Temporarily closed to accrual
Contact: Keith S. Lanier
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org
Yelm
Providence Regional Cancer System-Yelm
Status: Active
Contact: Alison Katherine Conlin
Phone: 907-212-6871 Email: AKPAMC.OncologyResearchSupport@providence.org

West Virginia

Huntington
Edwards Comprehensive Cancer Center
Status: Active
Contact: Maria Rosalia B. Tria Tirona
Phone: 304-399-6617

Wisconsin

Ashland
Ashland Memorial Medical Center
Status: Active
Name Not Available
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org
Duluth Clinic Ashland
Status: Active
Contact: Bret E.B. Friday
Phone: 773-702-9171 Email: protocols@AllianceNCTN.org
Eau Claire
Marshfield Clinic Cancer Center at Sacred Heart
Status: Temporarily closed to accrual
Contact: Adedayo A. Onitilo
Phone: 800-347-0673
Marshfield
Marshfield Clinic
Status: Active
Contact: Adedayo A. Onitilo
Phone: 800-347-0673
Milwaukee
Froedtert and the Medical College of Wisconsin
Status: Active
Contact: John A. Charlson
Phone: 414-805-4380
Minocqua
Marshfield Clinic-Minocqua Center
Status: Active
Contact: Adedayo A. Onitilo
Phone: 800-347-0673
New Richmond
Cancer Center of Western Wisconsin
Status: Active
Contact: Daniel M. Anderson
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Rice Lake
Lakeview Medical Center-Marshfield Clinic
Status: Active
Contact: Adedayo A. Onitilo
Phone: 800-347-0673
Marshfield Clinic-Rice Lake Center
Status: Active
Contact: Adedayo A. Onitilo
Phone: 800-347-0673
Stevens Point
Ascension Saint Michael's Hospital
Status: Temporarily closed to accrual
Contact: Adedayo A. Onitilo
Phone: 800-347-0673
Marshfield Clinic Stevens Point Center
Status: Active
Contact: Adedayo A. Onitilo
Phone: 855-829-8555
Wausau
Marshfield Clinic-Wausau Center
Status: Active
Contact: Adedayo A. Onitilo
Phone: 800-347-0673
Weston
Marshfield Clinic - Weston Center
Status: Active
Contact: Adedayo A. Onitilo
Phone: 800-347-0673
Wisconsin Rapids
Marshfield Clinic - Wisconsin Rapids Center
Status: Active
Contact: Adedayo A. Onitilo
Phone: 800-347-0673

Wyoming

Cheyenne
Cheyenne Regional Medical Center-West
Status: Active
Contact: Keren Sturtz
Phone: 303-777-2663 Email: ccrp@co-cancerresearch.org
Cody
Billings Clinic-Cody
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Sheridan
Welch Cancer Center
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org

Trial Objectives and Outline

PRIMARY OBJECTIVES:

I. To evaluate the confirmed response rate of single agent nivolumab and dual agent nivolumab plus ipilimumab in patients with locally advanced/unresectable or metastatic soft tissue sarcoma.

SECONDARY OBJECTIVES:

I. To evaluate adverse event rates (National Cancer Institute [NCI] Common Terminology Criteria for Adverse Events [CTCAE] version [v]4.0) within each treatment arm.

II. To evaluate duration of response, clinical benefit rate, time to progression, progression-free survival, and overall survival within each treatment arm.

TERTIARY OBJECTIVES:

I. To potentially detect an early signal of confirmed response rate within a histologically defined patient cohort.

II. To assess the potential association between programmed cell death 1 ligand 1 (PD-L1) expression (by immunohistochemistry [IHC]) and clinical outcome, within each treatment.

III. To evaluate associations between selected biomarker measured in serial peripheral blood and with clinical efficacy, within each treatment.

IV. To evaluate the association between selected biomarker measured in tumor tissue with clinical efficacy, within each treatment.

V. To evaluate the association between baseline tumor mutational burden and neoantigen production with clinical efficacy within each treatment.

VI. To evaluate secondary endpoints within patients crossing over to dual agent nivolumab plus ipilimumab after experiencing progressive disease while receiving single agent nivolumab.

VII. To evaluate correlative science objectives endpoints within patients crossing over to dual agent nivolumab plus ipilimumab after experiencing progressive disease while receiving single agent nivolumab.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive nivolumab intravenously (IV) over 30 minutes once every 2 weeks. Courses repeat every 42 days for up to 108 weeks in the absence of disease progression or unacceptable toxicity. Patients who progress after 10 weeks on single agent nivolumab may elect to cross over to Arm II.

ARM II: Patients receive nivolumab IV over 30 minutes and ipilimumab IV over 90 minutes once every 3 weeks for 12 weeks. Patients then receive nivolumab IV over 30 minutes every 2 weeks. Courses repeat every 42 days for up to 108 weeks in the absence of disease progression or unacceptable toxicity. Patients who progress by imaging during the first 12 weeks of therapy may continue treatment, at the discretion of the patient and treating investigator.

After completion of study treatment, patients are followed up at 4 weeks and then every 6 months for 3 years.

Trial Phase & Type

Trial Phase

Phase II

Trial Type

Treatment

Lead Organization

Lead Organization
Alliance for Clinical Trials in Oncology

Principal Investigator
Sandra Pierina D'Angelo

Trial IDs

Primary ID A091401
Secondary IDs NCI-2015-00260
Clinicaltrials.gov ID NCT02500797