Radiation Therapy With or Without Chemotherapy in Patients With Stage I or Stage II Cervical Cancer Who Previously Underwent Surgery

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Basic Trial Information

PhaseTypeStatusAgeTrial IDs
Phase IIITissue collection/Repository, TreatmentActive18 and overGOG-0263
NCI-2011-02037, CDR0000670125, NCT01101451

Trial Description

Summary

This randomized phase III trial studies radiation therapy with chemotherapy to see how well it works compared to radiation therapy alone in treating patients with stage I or stage II cervical cancer who previously underwent surgery. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether giving radiation therapy together with chemotherapy is more effective than radiation therapy alone in treating patients with cervical cancer.

Further Study Information

PRIMARY OBJECTIVES:

I. To determine if post-operative adjuvant chemo-radiation therapy (CRT) can significantly improve recurrence-free survival (RFS) when compared to radiation therapy (RT) alone in stage I-IIA cervical cancer patients with intermediate-risk factors after treatment with radical hysterectomy.

SECONDARY OBJECTIVES:

I. To determine whether post-operative adjuvant CRT can improve overall survival (OS) when compared to RT alone in stage I-IIA cervical cancer patients with intermediate risk factors after treatment with radical hysterectomy.

II. To assess differences (across treatment arms) in incidence and severity of therapy-attributed adverse events utilizing the active version of Common Terminology Criteria for Adverse Events (CTCAE).

III. To provide assessment of patient risk vs benefit (positive study only).

IV. To determine whether post-operative adjuvant CRT improves the health-related quality-of-life (QOL) (compared to RT alone) as measured by Functional Assessment of Cancer Therapy-Cervix (FACT-Cx) Trial Outcome Index (TOI) and produce favorable toxicity profiles (with particular focus on treatment related genitourinary, gastrointestinal, neurological, pain and sexual adverse events).

TERTIARY OBJECTIVES:

I. To bank archival tumor tissue for research studies, including studies that evaluate the association between biomarkers, RFS, OS, and clinical-surgical-pathologic characteristics in patients randomized to post-operative adjuvant CRT compared to RT alone.

II. To bank deoxyribonucleic acid (DNA) from whole blood for research studies, including studies that evaluate associations between single nucleotide polymorphisms (SNPs), and measures of clinical outcome, including RFS, OS, and adverse events in patients randomized to post-operative adjuvant CRT compared to RT alone.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients undergo pelvic external-beam radiation therapy (EBRT) or intensity-modulated radiation therapy (IMRT) 5 days a week for 5.5 weeks.

ARM II: Patients receive cisplatin IV over 1-2 hours on day 1 and undergo radiotherapy as in Arm I. Treatment with cisplatin repeats every 7 days for up to 6 courses in the absence of disease progression or unacceptable toxicity.

After completion of study therapy, patients are followed up every 3 months for 2 years, every 6 months for 3 years, and then annually thereafter.

Eligibility Criteria

Inclusion Criteria:

Pathologically proven primary cervical cancer I-IIA with squamous cell carcinoma, adenosquamous carcinoma or adenocarcinoma initially treated with a standard radical hysterectomy with pelvic lymphadenectomy

Patients with the following characteristics (depth of stromal invasion and lymphovascular space involvement to be pathologically confirmed):

Positive capillary-lymphovascular space involvement and one of the following:

  • Deep third penetration
  • Middle third penetration, clinical tumor ≥ 2 cm
  • Superficial third penetration, clinical tumor ≥ 5 cm

Negative capillary-lymphatic space involvement

  • Middle or deep third penetration, clinical tumor ≥ 4 cm

Absolute neutrophil count (ANC) ≥ 1,500/mcl

Platelets ≥ 100,000/mcl

Creatinine ≤ upper limit of normal (ULN) or calculated creatinine clearance ≥ 60 mL/min

Bilirubin ≤ 1.5 times normal

Alkaline phosphate ≤ 3 times normal

Serum glutamic oxaloacetic transaminase (SGOT) ≤ 3 times normal

Gynecologic Oncology Group (GOG) performance status 0, 1, 2

Patients should not be randomized less than 3 weeks post-surgery but will not be acceptable for randomization more than 8 weeks post-surgery

Patients who have met the pre-entry requirements

Patients must have signed an approved informed consent and authorization permitting release of personal health information

Exclusion Criteria:

Patients with tumor in the parametria, pelvic lymph nodes or any other extra uterine site or with positive surgical margins

Patients with septicemia or severe infection

Patients with intestinal obstruction or gastrointestinal bleeding

Patients with postoperative fistula

Patients with cervix cancer who have received any previous radiation or chemotherapy

Patients whose circumstances do not permit completion of the study or the required follow-up

Patients with renal abnormalities requiring modification of radiation field (pelvic kidney, renal transplant, etc.)

Patients with GOG performance status of 3 or 4

Patients with a history of other invasive malignancies, with the exception of non-melanoma skin cancer, are excluded if there is any evidence of other malignancy being present within the last five years; patients are also excluded if their previous cancer treatment contraindicates this protocol therapy

Trial Contact Information

Trial Lead Organizations / Sponsors / Collaborators

Gynecologic Oncology Group

  • National Cancer Institute
Sang Young Ryu, Principal Investigator

Trial Sites

U.S.A.

Alaska
Anchorage

Alaska Breast Care and Surgery LLC

Benjamin Buckner Bridges
Ph: 208-381-3376
Email: mcdonagd@slhs.org

Benjamin Buckner Bridges
Principal Investigator

Alaska Oncology and Hematology LLC

Benjamin Buckner Bridges
Ph: 208-381-3376
Email: mcdonagd@slhs.org

Benjamin Buckner Bridges
Principal Investigator

Alaska Women's Cancer Care

Benjamin Buckner Bridges
Ph: 208-381-3376
Email: mcdonagd@slhs.org

Benjamin Buckner Bridges
Principal Investigator

Anchorage Associates in Radiation Medicine

Keith S. Lanier
Ph: 503-215-2614
Email: CanRsrchStudies@providence.org

Keith S. Lanier
Principal Investigator

Anchorage Oncology Centre

Keith S. Lanier
Ph: 503-215-2614
Email: CanRsrchStudies@providence.org

Keith S. Lanier
Principal Investigator

Katmai Oncology Group

Keith S. Lanier
Ph: 503-215-2614
Email: CanRsrchStudies@providence.org

Keith S. Lanier
Principal Investigator

Providence Alaska Medical Center

Keith S. Lanier
Ph: 503-215-2614
Email: CanRsrchStudies@providence.org

Keith S. Lanier
Principal Investigator

Arizona
Phoenix

University of Arizona Cancer Center at Saint Joseph's

John Hall Farley
Ph: 877-602-4111

John Hall Farley
Principal Investigator

California
Auburn

Sutter Auburn Faith Hospital

Stacy D. D'Andre
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Stacy D. D'Andre
Principal Investigator

Sutter Cancer Centers Radiation Oncology Services-Auburn

Stacy D. D'Andre
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Stacy D. D'Andre
Principal Investigator

Berkeley

Alta Bates Summit Medical Center-Herrick Campus

Stacy D. D'Andre
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Stacy D. D'Andre
Principal Investigator

Burbank

Providence Saint Joseph Medical Center/Disney Family Cancer Center

Keith S. Lanier
Ph: 503-215-2614
Email: CanRsrchStudies@providence.org

Keith S. Lanier
Principal Investigator

Burlingame

Mills - Peninsula Hospitals

Stacy D. D'Andre
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Stacy D. D'Andre
Principal Investigator

Cameron Park

Sutter Cancer Centers Radiation Oncology Services-Cameron Park

Stacy D. D'Andre
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Stacy D. D'Andre
Principal Investigator

Castro Valley

Eden Hospital Medical Center

Stacy D. D'Andre
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Stacy D. D'Andre
Principal Investigator

Concord

John Muir Medical Center-Concord Campus

Babak Edraki
Ph: 925-674-2580

Babak Edraki
Principal Investigator

Davis

Sutter Davis Hospital

Stacy D. D'Andre
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Stacy D. D'Andre
Principal Investigator

Loma Linda

Loma Linda University Medical Center

Yevgeniya Jane Mikhailovn Ioffe
Ph: 909-558-4050

Yevgeniya Jane Mikhailovn Ioffe
Principal Investigator

Modesto

Memorial Medical Center

Stacy D. D'Andre
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Stacy D. D'Andre
Principal Investigator

Mountain View

Palo Alto Medical Foundation-Camino Division

Stacy D. D'Andre
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Stacy D. D'Andre
Principal Investigator

Palo Alto Medical Foundation-Gynecologic Oncology

Stacy D. D'Andre
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Stacy D. D'Andre
Principal Investigator

Novato

Sutter Cancer Research Consortium

Stacy D. D'Andre
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Stacy D. D'Andre
Principal Investigator

Orange

UC Irvine Health/Chao Family Comprehensive Cancer Center

Krishnansu Sujata Tewari
Ph: 714-456-6191
Email: awallick@uci.edu

Krishnansu Sujata Tewari
Principal Investigator

Palo Alto

Palo Alto Medical Foundation Health Care

Stacy D. D'Andre
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Stacy D. D'Andre
Principal Investigator

Pomona

Pomona Valley Hospital Medical Center

Yallapragada S. (Ram) Rao
Ph: 909-865-9555

Yallapragada S. (Ram) Rao
Principal Investigator

Roseville

Sutter Cancer Centers Radiation Oncology Services-Roseville

Stacy D. D'Andre
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Stacy D. D'Andre
Principal Investigator

Sutter Roseville Medical Center

Stacy D. D'Andre
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Stacy D. D'Andre
Principal Investigator

Sacramento

Sutter General Hospital

Stacy D. D'Andre
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Stacy D. D'Andre
Principal Investigator

San Francisco

California Pacific Medical Center-Pacific Campus

Stacy D. D'Andre
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Stacy D. D'Andre
Principal Investigator

Santa Cruz

Palo Alto Medical Foundation-Santa Cruz

Stacy D. D'Andre
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Stacy D. D'Andre
Principal Investigator

Santa Rosa

Sutter Pacific Medical Foundation

Stacy D. D'Andre
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Stacy D. D'Andre
Principal Investigator

Sunnyvale

Palo Alto Medical Foundation-Sunnyvale

Stacy D. D'Andre
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Stacy D. D'Andre
Principal Investigator

Vacaville

Sutter Cancer Centers Radiation Oncology Services-Vacaville

Stacy D. D'Andre
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Stacy D. D'Andre
Principal Investigator

Vallejo

Sutter Solano Medical Center/Cancer Center

Stacy D. D'Andre
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Stacy D. D'Andre
Principal Investigator

Walnut Creek

John Muir Medical Center-Walnut Creek

Babak Edraki
Ph: 925-674-2580

Babak Edraki
Principal Investigator

Florida
Deerfield Beach

UM Sylvester Comprehensive Cancer Center at Deerfield Beach

Aaron H. Wolfson
Ph: 305-243-2647

Aaron H. Wolfson
Principal Investigator

Miami

Jackson Memorial Hospital-Holtz Children's Hospital

Aaron H. Wolfson
Ph: 305-243-2647

Aaron H. Wolfson
Principal Investigator

University of Miami Miller School of Medicine-Sylvester Cancer Center

Aaron H. Wolfson
Ph: 305-243-2647

Aaron H. Wolfson
Principal Investigator

Georgia
Gainesville

Northeast Georgia Medical Center-Gainesville

Andrew Emmons Green
Ph: 770-219-8800
Email: cancerpatient.navigator@nghs.com

Andrew Emmons Green
Principal Investigator

Savannah

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

William Edward Richards
Ph: 912-819-5704

William Edward Richards
Principal Investigator

Low Country Cancer Care Associates PC

James Joseph Burke
Ph: 912-350-8568

James Joseph Burke
Principal Investigator

Memorial University Medical Center

James Joseph Burke
Ph: 912-350-8568

James Joseph Burke
Principal Investigator

Summit Cancer Care-Memorial

James Joseph Burke
Ph: 912-350-8568

James Joseph Burke
Principal Investigator

Idaho
Boise

Saint Alphonsus Cancer Care Center-Boise

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Saint Luke's Mountain States Tumor Institute

Benjamin Buckner Bridges
Ph: 208-381-3376
Email: mcdonagd@slhs.org

Benjamin Buckner Bridges
Principal Investigator

Caldwell

Saint Alphonsus Cancer Care Center-Caldwell

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Coeur D'Alene

Kootenai Medical Center

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Emmett

Walter Knox Memorial Hospital

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Fruitland

Saint Luke's Mountain States Tumor Institute - Fruitland

Benjamin Buckner Bridges
Ph: 208-381-3376
Email: mcdonagd@slhs.org

Benjamin Buckner Bridges
Principal Investigator

Meridian

Idaho Urologic Institute-Meridian

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Saint Luke's Mountain States Tumor Institute - Meridian

Benjamin Buckner Bridges
Ph: 208-381-3376
Email: mcdonagd@slhs.org

Benjamin Buckner Bridges
Principal Investigator

Nampa

Saint Alphonsus Medical Center-Nampa

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Saint Luke's Mountain States Tumor Institute - Nampa

Benjamin Buckner Bridges
Ph: 208-381-3376
Email: mcdonagd@slhs.org

Benjamin Buckner Bridges
Principal Investigator

Post Falls

Kootenai Cancer Center

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Sandpoint

Kootenai Cancer Clinic

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Twin Falls

Saint Luke's Mountain States Tumor Institute-Twin Falls

Keith S. Lanier
Ph: 503-215-2614
Email: CanRsrchStudies@providence.org

Keith S. Lanier
Principal Investigator

Illinois
Aurora

Rush - Copley Medical Center

Sinisa Stanic
Ph: 800-446-5532

Sinisa Stanic
Principal Investigator

Bloomington

Illinois CancerCare-Bloomington

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Canton

Illinois CancerCare-Canton

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Carbondale

Memorial Hospital of Carbondale

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Carterville

SIH Cancer Institute

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Carthage

Illinois CancerCare-Carthage

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Centralia

Centralia Oncology Clinic

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Danville

Carle on Vermilion

Sinisa Stanic
Ph: 800-446-5532

Sinisa Stanic
Principal Investigator

Decatur

Cancer Care Center of Decatur

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Decatur Memorial Hospital

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Effingham

Carle Physician Group-Effingham

Sinisa Stanic
Ph: 800-446-5532

Sinisa Stanic
Principal Investigator

Crossroads Cancer Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Eureka

Illinois CancerCare-Eureka

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Galesburg

Illinois CancerCare-Galesburg

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Western Illinois Cancer Treatment Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Geneva

Northwestern Medicine Cancer Center Delnor

LaToya J. Perry
Ph: 630-315-1918
Email: Claudine.Gamster@CadenceHealth.org

LaToya J. Perry
Principal Investigator

Hinsdale

Sudarshan K Sharma MD Limted-Gynecologic Oncology

Sudarshan K. Sharma
Ph: 630-856-6757

Sudarshan K. Sharma
Principal Investigator

Kewanee

Illinois CancerCare-Kewanee Clinic

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Macomb

Illinois CancerCare-Macomb

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Mattoon

Carle Physician Group-Mattoon/Charleston

Sinisa Stanic
Ph: 800-446-5532

Sinisa Stanic
Principal Investigator

Maywood

Loyola University Medical Center

Ronald Keith Potkul
Ph: 708-226-4357

Ronald Keith Potkul
Principal Investigator

Mount Vernon

Good Samaritan Regional Health Center

Jay W. Carlson
Ph: 800-821-7532

Jay W. Carlson
Principal Investigator

Ottawa

Illinois CancerCare-Ottawa Clinic

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Pekin

Illinois CancerCare-Pekin

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Peoria

Illinois CancerCare-Peoria

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Methodist Medical Center of Illinois

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

OSF Saint Francis Medical Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

OSF Saint Francis Radiation Oncology at Peoria Cancer Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Peru

Illinois CancerCare-Peru

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Valley Radiation Oncology

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Princeton

Illinois CancerCare-Princeton

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Springfield

Central Illinois Hematology Oncology Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Memorial Medical Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Southern Illinois University School of Medicine

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Springfield Clinic

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Swansea

Cancer Care Specialists of Illinois-Swansea

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Memorial and Saint Elizabeth's Health Care Services LLP

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Urbana

Carle Cancer Center

Sinisa Stanic
Ph: 800-446-5532

Sinisa Stanic
Principal Investigator

The Carle Foundation Hospital

Sinisa Stanic
Ph: 800-446-5532

Sinisa Stanic
Principal Investigator

Warrenville

Northwestern Medicine Cancer Center Warrenville

LaToya J. Perry
Ph: 630-315-1918
Email: Claudine.Gamster@CadenceHealth.org

LaToya J. Perry
Principal Investigator

Yorkville

Rush-Copley Healthcare Center

Sinisa Stanic
Ph: 800-446-5532

Sinisa Stanic
Principal Investigator

Indiana
Fort Wayne

Parkview Hospital Randallia

Brian K. Chang
Ph: 260-373-8888
Email: parkviewresearch@parkview.com

Brian K. Chang
Principal Investigator

Radiation Oncology Associates PC

Brian K. Chang
Ph: 260-373-8888
Email: parkviewresearch@parkview.com

Brian K. Chang
Principal Investigator

Indianapolis

Saint Vincent Hospital and Health Care Center

Michael J. Callahan
Ph: 317-338-2194
Email: research@stvincent.org

Michael J. Callahan
Principal Investigator

Mishawaka

Memorial Regional Cancer Center Day Road

Nonyem A. Onujiogu
Ph: 800-284-7370

Nonyem A. Onujiogu
Principal Investigator

South Bend

Memorial Hospital of South Bend

Nonyem A. Onujiogu
Ph: 800-284-7370

Nonyem A. Onujiogu
Principal Investigator

Iowa
Ames

Mary Greeley Medical Center

Joseph James Merchant
Ph: 515-239-2621

Joseph James Merchant
Principal Investigator

McFarland Clinic PC-William R Bliss Cancer Center

Joseph James Merchant
Ph: 515-239-2621

Joseph James Merchant
Principal Investigator

Boone

McFarland Clinic PC-Boone

Joseph James Merchant
Ph: 515-239-2621

Joseph James Merchant
Principal Investigator

Des Moines

Iowa Lutheran Hospital

Robert J. Behrens
Ph: 515-282-2921

Robert J. Behrens
Principal Investigator

Iowa Methodist Medical Center

Robert J. Behrens
Ph: 515-282-2921

Robert J. Behrens
Principal Investigator

Iowa-Wide Oncology Research Coalition NCORP

Robert J. Behrens
Ph: 515-282-2921

Robert J. Behrens
Principal Investigator

Medical Oncology and Hematology Associates-Des Moines

Robert J. Behrens
Ph: 515-282-2921

Robert J. Behrens
Principal Investigator

Fort Dodge

McFarland Clinic PC-Trinity Cancer Center

Joseph James Merchant
Ph: 515-239-2621

Joseph James Merchant
Principal Investigator

Jefferson

McFarland Clinic PC-Jefferson

Joseph James Merchant
Ph: 515-239-2621

Joseph James Merchant
Principal Investigator

Marshalltown

McFarland Clinic PC-Marshalltown

Joseph James Merchant
Ph: 515-239-2621

Joseph James Merchant
Principal Investigator

West Des Moines

Methodist West Hospital

Robert J. Behrens
Ph: 515-282-2921

Robert J. Behrens
Principal Investigator

Kansas
Kansas City

University of Kansas Cancer Center

Gary Alan Johnson
Ph: 913-945-7552
Email: ctnursenav@kumc.edu

Gary Alan Johnson
Principal Investigator

Kentucky
Lexington

University of Kentucky/Markey Cancer Center

Frederick Rand Ueland
Ph: 859-257-3379

Frederick Rand Ueland
Principal Investigator

Louisiana
Baton Rouge

Mary Bird Perkins Cancer Center

Augusto C. Ochoa
Ph: 504-568-2428
Email: emede1@lsuhsc.edu

Augusto C. Ochoa
Principal Investigator

Woman's Hospital

M. Giles Fort
Ph: 225-231-5296
Email: Ericka.Seidemann@womans.org

M. Giles Fort
Principal Investigator

Covington

Mary Bird Cancer Center/Saint Tammany Parish

Augusto C. Ochoa
Ph: 504-568-2428
Email: emede1@lsuhsc.edu

Augusto C. Ochoa
Principal Investigator

Women's Cancer Care-Covington

Patricia S. Braly
Ph: 504-883-2960
Email: info@womenscc.com

Patricia S. Braly
Principal Investigator

New Orleans

Louisiana State University Health Science Center

Augusto C. Ochoa
Ph: 504-568-2428
Email: emede1@lsuhsc.edu

Augusto C. Ochoa
Principal Investigator

Maine
Scarborough

Maine Medical Center- Scarborough Campus

Matthew D. Cheney
Ph: 207-885-7565

Matthew D. Cheney
Principal Investigator

Maryland
Bethesda

Walter Reed National Military Medical Center

William J. Lowery
Ph: 301-319-2100

William J. Lowery
Principal Investigator

Michigan
Ann Arbor

Saint Joseph Mercy Hospital

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Brighton

IHA Hematology Oncology Consultants-Brighton

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Saint Joseph Mercy Brighton

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Canton

IHA Hematology Oncology Consultants-Canton

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Saint Joseph Mercy Canton Health Center

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Caro

Caro Cancer Center

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Chelsea

IHA Hematology Oncology Consultants-Chelsea

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Saint Joseph Mercy Chelsea

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Clarkston

Hematology Oncology Consultants-Clarkston

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Newland Medical Associates-Clarkston

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Dearborn

Beaumont Hospital-Dearborn

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Detroit

Saint John Hospital and Medical Center

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

East China

Great Lakes Cancer Management Specialists-Doctors Park

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Flint

Genesee Cancer and Blood Disease Treatment Center

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Genesee Hematology Oncology PC

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Genesys Hurley Cancer Institute

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Hurley Medical Center

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Gorsse Pointe Woods

Lymphoma Clinic of Michigan

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Grosse Pointe Woods

Great Lakes Cancer Management Specialists-Van Elslander Cancer Center

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Michigan Breast Specialists-Grosse Pointe Woods

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Jackson

Allegiance Health

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Kalamazoo

West Michigan Cancer Center

Sunil Nagpal
Ph: 616-391-1230
Email: crcwm-regulatory@crcwm.org

Sunil Nagpal
Principal Investigator

Lansing

Sparrow Hospital

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Livonia

Hope Cancer Clinic

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Saint Mary Mercy Hospital

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Macomb Township

Hematology Oncology Associates East PC

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Michigan Breast Specialists-Macomb Township

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Monroe

Monroe Cancer Center

Jeffrey Henry Muler
Ph: 419-824-1842

Jeffrey Henry Muler
Principal Investigator

Novi

Assarian Cancer Center

Vinay Kumar Malviya
Ph: 248-849-5337
Email: jaswinder.grewal@stjohn.org

Vinay Kumar Malviya
Principal Investigator

Pontiac

21st Century Oncology-Pontiac

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Hope Cancer Center

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Newland Medical Associates-Pontiac

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Saint Joseph Mercy Oakland

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Rochester Hills

Great Lakes Cancer Management Specialists-Rochester Hills

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Saginaw

Oncology Hematology Associates of Saginaw Valley PC

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Saint Mary's of Michigan

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Southfield

Providence Hospital-Southfield Cancer Center

Vinay Kumar Malviya
Ph: 248-849-5337
Email: jaswinder.grewal@stjohn.org

Vinay Kumar Malviya
Principal Investigator

Sterling Heights

Bhadresh Nayak MD PC-Sterling Heights

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Warren

Great Lakes Cancer Management Specialists-Macomb Professional Building

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Macomb Hematology Oncology PC

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Michigan Breast Specialists-Warren

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Saint John Macomb-Oakland Hospital

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

West Branch

Saint Mary's Oncology/Hematology Associates of West Branch

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Ypsilanti

Huron Gastroenterology PC

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

IHA Hematology Oncology Consultants-Ann Arbor

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Minnesota
Burnsville

Fairview Ridges Hospital

Rachel E. Lerner
Ph: 952-993-1517
Email: mmcorc@parknicollet.com

Rachel E. Lerner
Principal Investigator

Coon Rapids

Mercy Hospital

Rachel E. Lerner
Ph: 952-993-1517
Email: mmcorc@parknicollet.com

Rachel E. Lerner
Principal Investigator

Edina

Fairview-Southdale Hospital

Rachel E. Lerner
Ph: 952-993-1517
Email: mmcorc@parknicollet.com

Rachel E. Lerner
Principal Investigator

Fridley

Unity Hospital

Rachel E. Lerner
Ph: 952-993-1517
Email: mmcorc@parknicollet.com

Rachel E. Lerner
Principal Investigator

Maple Grove

Fairview Maple Grove Medical Center

Rachel E. Lerner
Ph: 952-993-1517
Email: mmcorc@parknicollet.com

Rachel E. Lerner
Principal Investigator

Maplewood

Minnesota Oncology Hematology PA-Maplewood

Rachel E. Lerner
Ph: 952-993-1517
Email: mmcorc@parknicollet.com

Rachel E. Lerner
Principal Investigator

Saint John's Hospital - Healtheast

Rachel E. Lerner
Ph: 952-993-1517
Email: mmcorc@parknicollet.com

Rachel E. Lerner
Principal Investigator

Minneapolis

Abbott-Northwestern Hospital

Rachel E. Lerner
Ph: 952-993-1517
Email: mmcorc@parknicollet.com

Rachel E. Lerner
Principal Investigator

Health Partners Inc

Rachel E. Lerner
Ph: 952-993-1517
Email: mmcorc@parknicollet.com

Rachel E. Lerner
Principal Investigator

Hennepin County Medical Center

Rachel E. Lerner
Ph: 952-993-1517
Email: mmcorc@parknicollet.com

Rachel E. Lerner
Principal Investigator

New Ulm

New Ulm Medical Center

Rachel E. Lerner
Ph: 952-993-1517
Email: mmcorc@parknicollet.com

Rachel E. Lerner
Principal Investigator

Robbinsdale

North Memorial Medical Health Center

Rachel E. Lerner
Ph: 952-993-1517
Email: mmcorc@parknicollet.com

Rachel E. Lerner
Principal Investigator

Saint Louis Park

Metro Minnesota Community Oncology Research Consortium

Matthew P. Boente
Ph: 952-993-1517
Email: mmcorc@parknicollet.com

Matthew P. Boente
Principal Investigator

Park Nicollet Clinic - Saint Louis Park

Rachel E. Lerner
Ph: 952-993-1517
Email: mmcorc@parknicollet.com

Rachel E. Lerner
Principal Investigator

Saint Paul

Regions Hospital

Rachel E. Lerner
Ph: 952-993-1517
Email: mmcorc@parknicollet.com

Rachel E. Lerner
Principal Investigator

United Hospital

Rachel E. Lerner
Ph: 952-993-1517
Email: mmcorc@parknicollet.com

Rachel E. Lerner
Principal Investigator

Shakopee

Saint Francis Regional Medical Center

Rachel E. Lerner
Ph: 952-993-1517
Email: mmcorc@parknicollet.com

Rachel E. Lerner
Principal Investigator

Stillwater

Lakeview Hospital

Rachel E. Lerner
Ph: 952-993-1517
Email: mmcorc@parknicollet.com

Rachel E. Lerner
Principal Investigator

Waconia

Ridgeview Medical Center

Rachel E. Lerner
Ph: 952-993-1517
Email: mmcorc@parknicollet.com

Rachel E. Lerner
Principal Investigator

Willmar

Rice Memorial Hospital

Rachel E. Lerner
Ph: 952-993-1517
Email: mmcorc@parknicollet.com

Rachel E. Lerner
Principal Investigator

Woodbury

Minnesota Oncology Hematology PA-Woodbury

Rachel E. Lerner
Ph: 952-993-1517
Email: mmcorc@parknicollet.com

Rachel E. Lerner
Principal Investigator

Wyoming

Fairview Lakes Medical Center

Rachel E. Lerner
Ph: 952-993-1517
Email: mmcorc@parknicollet.com

Rachel E. Lerner
Principal Investigator

Mississippi
Jackson

University of Mississippi Medical Center

James Tate Thigpen
Ph: 601-815-6700

James Tate Thigpen
Principal Investigator

Pascagoula

Singing River Hospital

James E. Clarkson
Ph: 228-809-5292

James E. Clarkson
Principal Investigator

Missouri
Bolivar

Central Care Cancer Center-Carrie J Babb Cancer Center

Jay W. Carlson
Ph: 800-821-7532

Jay W. Carlson
Principal Investigator

Bonne Terre

Parkland Health Center-Bonne Terre

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Branson

CoxHealth Cancer Center

Jay W. Carlson
Ph: 800-821-7532

Jay W. Carlson
Principal Investigator

Cape Girardeau

Saint Francis Medical Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Southeast Cancer Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Jefferson City

Capital Region Medical Center-Goldschmidt Cancer Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Joplin

Freeman Health System

Jay W. Carlson
Ph: 800-821-7532

Jay W. Carlson
Principal Investigator

Mercy Hospital-Joplin

Jay W. Carlson
Ph: 800-821-7532

Jay W. Carlson
Principal Investigator

Rolla

Delbert Day Cancer Institute at PCRMC

Jay W. Carlson
Ph: 800-821-7532

Jay W. Carlson
Principal Investigator

Saint John's Clinic-Rolla-Cancer and Hematology

Jay W. Carlson
Ph: 800-821-7532

Jay W. Carlson
Principal Investigator

Saint Louis

Mercy Hospital Saint Louis

Jay W. Carlson
Ph: 800-821-7532

Jay W. Carlson
Principal Investigator

Missouri Baptist Medical Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Saint Louis Cancer and Breast Institute-South City

Jay W. Carlson
Ph: 800-821-7532

Jay W. Carlson
Principal Investigator

Sainte Genevieve

Sainte Genevieve County Memorial Hospital

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Springfield

CoxHealth South Hospital

Jay W. Carlson
Ph: 800-821-7532

Jay W. Carlson
Principal Investigator

Mercy Hospital Springfield

Jay W. Carlson
Ph: 800-821-7532

Jay W. Carlson
Principal Investigator

Sullivan

Missouri Baptist Sullivan Hospital

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Sunset Hills

Missouri Baptist Outpatient Center-Sunset Hills

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Montana
Anaconda

Community Hospital of Anaconda

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Billings

Billings Clinic Cancer Center

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Saint Vincent Healthcare

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Bozeman

Bozeman Deaconess Hospital

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Great Falls

Benefis Healthcare- Sletten Cancer Institute

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Great Falls Clinic

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Helena

Saint Peter's Community Hospital

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Kalispell

Kalispell Regional Medical Center

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Missoula

Community Medical Hospital

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Saint Patrick Hospital - Community Hospital

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Nebraska
Omaha

Nebraska Methodist Hospital

Peter Craig Morris
Ph: 402-354-7939
Email: kathryn.bartz@nmhs.org

Peter Craig Morris
Principal Investigator

New Hampshire
Lebanon

Dartmouth Hitchcock Medical Center

Leslie R. DeMars
Ph: 800-639-6918
Email: cancer.research.nurse@dartmouth.edu

Leslie R. DeMars
Principal Investigator

New Jersey
Basking Ridge

Memorial Sloan Kettering Cancer Center at Basking Ridge

Mario Mendes Leitao
Ph: 212-639-7202

Mario Mendes Leitao
Principal Investigator

Long Branch

Monmouth Medical Center

Mitchell F. Weiss
Ph: 732-923-7689

Mitchell F. Weiss
Principal Investigator

Mount Holly

Virtua Memorial

Randolph Bruce Deger
Ph: 609-914-6762

Randolph Bruce Deger
Principal Investigator

Paramus

The Valley Hospital-Luckow Pavilion

Noah A. Goldman
Ph: 201-634-5792

Noah A. Goldman
Principal Investigator

Ridgewood

Valley Hospital

Noah A. Goldman
Ph: 201-634-5792

Noah A. Goldman
Principal Investigator

Voorhees

Virtua Voorhees

Randolph Bruce Deger
Ph: 609-914-6762

Randolph Bruce Deger
Principal Investigator

Westwood

Valley Health System-Hematology/Oncology

Noah A. Goldman
Ph: 201-634-5792

Noah A. Goldman
Principal Investigator

New Mexico
Albuquerque

Lovelace Medical Center-Saint Joseph Square

Carolyn Y. Muller
Ph: 505-925-0366
Email: LByatt@nmcca.org

Carolyn Y. Muller
Principal Investigator

Lovelace Radiation Oncology

Carolyn Y. Muller
Ph: 505-925-0366
Email: LByatt@nmcca.org

Carolyn Y. Muller
Principal Investigator

Southwest Gynecologic Oncology Associates Inc

Carolyn Y. Muller
Ph: 505-925-0366
Email: LByatt@nmcca.org

Carolyn Y. Muller
Principal Investigator

University of New Mexico Cancer Center

Carolyn Y. Muller
Ph: 505-925-0366
Email: LByatt@nmcca.org

Carolyn Y. Muller
Principal Investigator

Las Cruces

Memorial Medical Center - Las Cruces

Carolyn Y. Muller
Ph: 505-925-0366
Email: LByatt@nmcca.org

Carolyn Y. Muller
Principal Investigator

New York
Brooklyn

New York-Presbyterian/Brooklyn Methodist Hospital

Katherine Economos
Ph: 718-780-3677
Email: Adg9003@nyp.org

Katherine Economos
Principal Investigator

Commack

Memorial Sloan Kettering Commack

Mario Mendes Leitao
Ph: 212-639-7202

Mario Mendes Leitao
Principal Investigator

New York

Memorial Sloan-Kettering Cancer Center

Mario Mendes Leitao
Ph: 212-639-7202

Mario Mendes Leitao
Principal Investigator

Rochester

Highland Hospital

Richard G. Moore
Ph: 585-275-5830

Richard G. Moore
Principal Investigator

University of Rochester

Richard G. Moore
Ph: 585-275-5830

Richard G. Moore
Principal Investigator

Rockville Centre

Memorial Sloan Kettering Rockville Centre

Mario Mendes Leitao
Ph: 212-639-7202

Mario Mendes Leitao
Principal Investigator

West Harrison

Memorial Sloan Kettering Westchester

Mario Mendes Leitao
Ph: 212-639-7202

Mario Mendes Leitao
Principal Investigator

North Carolina
Chapel Hill

UNC Lineberger Comprehensive Cancer Center

Linda Van Le
Ph: 877-668-0683
Email: cancerclinicaltrials@med.unc.edu

Linda Van Le
Principal Investigator

Charlotte

Novant Health Presbyterian Medical Center

John Matthew McDonald
Ph: 704-384-5369

John Matthew McDonald
Principal Investigator

Oncology Specialists of Charlotte

John Matthew McDonald
Ph: 704-384-5369

John Matthew McDonald
Principal Investigator

Southern Oncology Specialists-Charlotte

John Matthew McDonald
Ph: 704-384-5369

John Matthew McDonald
Principal Investigator

Clinton

Southeastern Medical Oncology Center-Clinton

James N. Atkins
Ph: 919-580-0000

James N. Atkins
Principal Investigator

Goldsboro

Southeastern Medical Oncology Center-Goldsboro

James N. Atkins
Ph: 919-580-0000

James N. Atkins
Principal Investigator

Wayne Memorial Hospital

James N. Atkins
Ph: 919-580-0000

James N. Atkins
Principal Investigator

Huntersville

Lake Norman Hematology Oncology Specialists-Huntersville

John Matthew McDonald
Ph: 704-384-5369

John Matthew McDonald
Principal Investigator

Southern Oncology Specialists-Huntersville

John Matthew McDonald
Ph: 704-384-5369

John Matthew McDonald
Principal Investigator

Jacksonville

Onslow Memorial Hospital

James N. Atkins
Ph: 919-580-0000

James N. Atkins
Principal Investigator

Southeastern Medical Oncology Center-Jacksonville

James N. Atkins
Ph: 919-580-0000

James N. Atkins
Principal Investigator

Matthews

Matthews Radiation Oncology Center

John Matthew McDonald
Ph: 704-384-5369

John Matthew McDonald
Principal Investigator

Novant Health Cancer Specialists-Matthews

John Matthew McDonald
Ph: 704-384-5369

John Matthew McDonald
Principal Investigator

Mooresville

Lake Norman Hematology Oncology Specialists-Mooresville

John Matthew McDonald
Ph: 704-384-5369

John Matthew McDonald
Principal Investigator

Wilson

Southeastern Medical Oncology Center-Wilson

James N. Atkins
Ph: 919-580-0000

James N. Atkins
Principal Investigator

Ohio
Akron

Summa Akron City Hospital/Cooper Cancer Center

Vivian E. von Gruenigen
Ph: 330-375-6101

Vivian E. von Gruenigen
Principal Investigator

Belpre

Strecker Cancer Center-Belpre

John Philip Kuebler
Ph: 614-566-3275

John Philip Kuebler
Principal Investigator

Chillicothe

Adena Regional Medical Center

John Philip Kuebler
Ph: 800-446-5532

John Philip Kuebler
Principal Investigator

Cleveland

Case Western Reserve University

Steven E. Waggoner
Ph: 800-641-2422

Steven E. Waggoner
Principal Investigator

Cleveland Clinic Cancer Center/Fairview Hospital

Peter G. Rose
Ph: 866-223-8100

Peter G. Rose
Principal Investigator

Cleveland Clinic Foundation

Peter G. Rose
Ph: 866-223-8100

Peter G. Rose
Principal Investigator

MetroHealth Medical Center

Kimberly Erin Resnick
Ph: 216-778-8526
Email: kbauchens@metrohealth.org

Kimberly Erin Resnick
Principal Investigator

Columbus

Columbus Oncology and Hematology Associates Inc

John Philip Kuebler
Ph: 614-566-3275

John Philip Kuebler
Principal Investigator

Doctors Hospital

John Philip Kuebler
Ph: 800-446-5532

John Philip Kuebler
Principal Investigator

Grant Medical Center

John Philip Kuebler
Ph: 614-566-3275

John Philip Kuebler
Principal Investigator

Mount Carmel East Hospital

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

Mount Carmel Health Center West

John Philip Kuebler
Ph: 800-446-5532

John Philip Kuebler
Principal Investigator

Ohio State University Comprehensive Cancer Center

David M. O'Malley
Ph: 800-293-5066
Email: Jamesline@osumc.edu

David M. O'Malley
Principal Investigator

Riverside Methodist Hospital

John Philip Kuebler
Ph: 800-446-5532

John Philip Kuebler
Principal Investigator

The Mark H Zangmeister Center

John Philip Kuebler
Ph: 502-361-8496

John Philip Kuebler
Principal Investigator

Delaware

Delaware Health Center-Grady Cancer Center

John Philip Kuebler
Ph: 614-566-3275

John Philip Kuebler
Principal Investigator

Delaware Radiation Oncology

John Philip Kuebler
Ph: 614-566-3275

John Philip Kuebler
Principal Investigator

Grady Memorial Hospital

John Philip Kuebler
Ph: 800-446-5532

John Philip Kuebler
Principal Investigator

Lancaster

Fairfield Medical Center

John Philip Kuebler
Ph: 614-566-3275

John Philip Kuebler
Principal Investigator

Mansfield

OhioHealth Mansfield Hospital

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

Marietta

Marietta Memorial Hospital

John Philip Kuebler
Ph: 800-446-5532

John Philip Kuebler
Principal Investigator

Marion

OneHealth Marion General Hospital

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

Mayfield Heights

Hillcrest Hospital Cancer Center

Peter G. Rose
Ph: 866-223-8100

Peter G. Rose
Principal Investigator

Mentor

Lake University Ireland Cancer Center

Steven E. Waggoner
Ph: 800-641-2422

Steven E. Waggoner
Principal Investigator

Mount Vernon

Knox Community Hospital

John Philip Kuebler
Ph: 614-566-3275

John Philip Kuebler
Principal Investigator

Newark

Licking Memorial Hospital

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

Newark Radiation Oncology

John Philip Kuebler
Ph: 614-566-3275

John Philip Kuebler
Principal Investigator

Portsmouth

Southern Ohio Medical Center

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

Sylvania

Flower Hospital

Jeffrey Henry Muler
Ph: 419-824-1842

Jeffrey Henry Muler
Principal Investigator

Toledo

The Toledo Hospital/Toledo Children's Hospital

Jeffrey Henry Muler
Ph: 419-824-1842

Jeffrey Henry Muler
Principal Investigator

Westerville

Saint Ann's Hospital

John Philip Kuebler
Ph: 800-446-5532

John Philip Kuebler
Principal Investigator

Zanesville

Genesis Healthcare System Cancer Care Center

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

Oklahoma
Oklahoma City

University of Oklahoma Health Sciences Center

Robert S. Mannel
Ph: 405-271-8777
Email: ou-clinical-trials@ouhsc.edu

Robert S. Mannel
Principal Investigator

Tulsa

Oklahoma Cancer Specialists and Research Institute-Tulsa

Robert S. Mannel
Ph: 405-271-8777
Email: ou-clinical-trials@ouhsc.edu

Robert S. Mannel
Principal Investigator

Oregon
Baker City

Saint Alphonsus Medical Center-Baker City

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Bend

Saint Charles Health System

Keith S. Lanier
Ph: 503-215-2614
Email: CanRsrchStudies@providence.org

Keith S. Lanier
Principal Investigator

Clackamas

Clackamas Radiation Oncology Center

Benjamin Buckner Bridges
Ph: 208-381-3376
Email: mcdonagd@slhs.org

Benjamin Buckner Bridges
Principal Investigator

Providence Oncology and Hematology Care Southeast

Keith S. Lanier
Ph: 503-215-2614
Email: CanRsrchStudies@providence.org

Keith S. Lanier
Principal Investigator

Coos Bay

Bay Area Hospital

Benjamin Buckner Bridges
Ph: 208-381-3376
Email: mcdonagd@slhs.org

Benjamin Buckner Bridges
Principal Investigator

Gresham

Legacy Mount Hood Medical Center

William E. Winter
Ph: 800-220-4937
Email: cancer@lhs.org

William E. Winter
Principal Investigator

Newberg

Providence Newberg Medical Center

Benjamin Buckner Bridges
Ph: 208-381-3376
Email: mcdonagd@slhs.org

Benjamin Buckner Bridges
Principal Investigator

Ontario

Saint Alphonsus Medical Center-Ontario

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Oregon City

Providence Willamette Falls Medical Center

Benjamin Buckner Bridges
Ph: 208-381-3376
Email: mcdonagd@slhs.org

Benjamin Buckner Bridges
Principal Investigator

Portland

Legacy Good Samaritan Hospital and Medical Center

William E. Winter
Ph: 800-220-4937
Email: cancer@lhs.org

William E. Winter
Principal Investigator

Providence Portland Medical Center

Keith S. Lanier
Ph: 503-215-2614
Email: CanRsrchStudies@providence.org

Keith S. Lanier
Principal Investigator

Providence Saint Vincent Medical Center

Keith S. Lanier
Ph: 503-215-2614
Email: CanRsrchStudies@providence.org

Keith S. Lanier
Principal Investigator

Tualatin

Legacy Meridian Park Hospital

William E. Winter
Ph: 800-220-4937
Email: cancer@lhs.org

William E. Winter
Principal Investigator

Pennsylvania
Abington

Abington Memorial Hospital

Joel I. Sorosky
Ph: 215-481-2402

Joel I. Sorosky
Principal Investigator

Allentown

Lehigh Valley Hospital-Cedar Crest

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Bethlehem

Lehigh Valley Hospital - Muhlenberg

J. Rebecca Liu
Ph: 734-712-3456

J. Rebecca Liu
Principal Investigator

Danville

Geisinger Medical Center

Radhika P. Gogoi
Ph: 570-271-5251

Radhika P. Gogoi
Principal Investigator

Easton

Easton Hospital

Rajen P. Oza
Ph: 973-729-7001

Rajen P. Oza
Principal Investigator

Philadelphia

Drexel University School of Medicine

Scott Daniel Richard
Ph: 866-884-4484

Scott Daniel Richard
Principal Investigator

University of Pennsylvania/Abramson Cancer Center

Robert Allen Burger
Ph: 215-746-7406

Robert Allen Burger
Principal Investigator

Pittsburgh

West Penn Hospital

Thomas Carl Krivak
Ph: 412-578-5000

Thomas Carl Krivak
Principal Investigator

West Reading

Reading Hospital

Bernice L. Robinson-Bennett
Ph: 610-988-9323

Bernice L. Robinson-Bennett
Principal Investigator

Wilkes-Barre

Geisinger Wyoming Valley/Henry Cancer Center

Radhika P. Gogoi
Ph: 570-271-5251

Radhika P. Gogoi
Principal Investigator

Rhode Island
Providence

Women and Infants Hospital

Paul A. DiSilvestro
Ph: 401-274-1122

Paul A. DiSilvestro
Principal Investigator

South Carolina
Easley

Greenville Health System Cancer Institute-Easley

Jeffrey W. Elder
Ph: 864-679-3966

Jeffrey W. Elder
Principal Investigator

Greenville

Greenville Health System Cancer Institute-Butternut

Jeffrey W. Elder
Ph: 864-679-3966

Jeffrey W. Elder
Principal Investigator

Greenville Health System Cancer Institute-Eastside

Jeffrey W. Elder
Ph: 864-679-3966

Jeffrey W. Elder
Principal Investigator

Greenville Health System Cancer Institute-Faris

Jeffrey W. Elder
Ph: 864-679-3966

Jeffrey W. Elder
Principal Investigator

Greenville Memorial Hospital

Jeffrey W. Elder
Ph: 864-679-3966

Jeffrey W. Elder
Principal Investigator

Saint Francis Cancer Center

David Griffin
Ph: 864-512-1000

David Griffin
Principal Investigator

Saint Francis Hospital

David Griffin
Ph: 864-512-1000

David Griffin
Principal Investigator

Greer

Greenville Health System Cancer Institute-Greer

Jeffrey W. Elder
Ph: 864-679-3966

Jeffrey W. Elder
Principal Investigator

Seneca

Greenville Health System Cancer Institute-Seneca

Jeffrey W. Elder
Ph: 864-679-3966

Jeffrey W. Elder
Principal Investigator

Spartanburg

Greenville Health System Cancer Institute-Spartanburg

Jeffrey W. Elder
Ph: 864-679-3966

Jeffrey W. Elder
Principal Investigator

South Dakota
Rapid City

Rapid City Regional Hospital

Michael O. Robinson
Ph: 605-716-3982
Email: research@rcrh.org

Michael O. Robinson
Principal Investigator

Sioux Falls

Avera Cancer Institute

Luis A. Rojas-Espaillat
Ph: 888-634-7268
Email: oncregulatory@avera.org

Luis A. Rojas-Espaillat
Principal Investigator

Texas
Austin

Austin Cancer Centers-Central Austin

James Stuart Ferriss
Ph: 512-324-7991

James Stuart Ferriss
Principal Investigator

Austin Cancer Centers-North

James Stuart Ferriss
Ph: 512-324-7991

James Stuart Ferriss
Principal Investigator

University Medical Center Brackenridge

James Stuart Ferriss
Ph: 512-324-7991

James Stuart Ferriss
Principal Investigator

Dallas

Parkland Memorial Hospital

David Scott Miller
Ph: 214-648-7097

David Scott Miller
Principal Investigator

UT Southwestern/Simmons Cancer Center-Dallas

David Scott Miller
Ph: 214-648-7097

David Scott Miller
Principal Investigator

Galveston

University of Texas Medical Branch

Lyuba Levine
Ph: 409-772-1950
Email: clinical.research@utmb.edu

Lyuba Levine
Principal Investigator

Houston

Memorial Hermann Texas Medical Center

Joseph Anthony Lucci
Ph: 713-792-3245

Joseph Anthony Lucci
Principal Investigator

The Methodist Hospital System

Aparna A. Kamat
Ph: 713-790-2700

Aparna A. Kamat
Principal Investigator

Sugar Land

Houston Methodist Sugar Land Hospital

Aparna A. Kamat
Ph: 713-790-2700

Aparna A. Kamat
Principal Investigator

Utah
American Fork

American Fork Hospital / Huntsman Intermountain Cancer Center

R. Jeffrey Lee
Ph: 801-507-3950

R. Jeffrey Lee
Principal Investigator

Cedar City

Sandra L Maxwell Cancer Center

R. Jeffrey Lee
Ph: 801-507-3950

R. Jeffrey Lee
Principal Investigator

Logan

Logan Regional Hospital

R. Jeffrey Lee
Ph: 801-507-3950

R. Jeffrey Lee
Principal Investigator

Murray

Intermountain Medical Center

R. Jeffrey Lee
Ph: 801-507-3950

R. Jeffrey Lee
Principal Investigator

Ogden

McKay-Dee Hospital Center

R. Jeffrey Lee
Ph: 801-507-3950

R. Jeffrey Lee
Principal Investigator

Provo

Utah Valley Regional Medical Center

R. Jeffrey Lee
Ph: 801-507-3950

R. Jeffrey Lee
Principal Investigator

Riverton

Riverton Hospital

R. Jeffrey Lee
Ph: 801-507-3950

R. Jeffrey Lee
Principal Investigator

Saint George

Dixie Medical Center Regional Cancer Center

R. Jeffrey Lee
Ph: 801-507-3950

R. Jeffrey Lee
Principal Investigator

Salt Lake City

LDS Hospital

R. Jeffrey Lee
Ph: 801-507-3950

R. Jeffrey Lee
Principal Investigator

Utah Cancer Specialists-Salt Lake City

R. Jeffrey Lee
Ph: 801-507-3950

R. Jeffrey Lee
Principal Investigator

Virginia
Portsmouth

Naval Medical Center - Portsmouth

Edward F. Miles
Ph: 757-953-5939

Edward F. Miles
Principal Investigator

Washington
Aberdeen

Providence Regional Cancer System-Aberdeen

Keith S. Lanier
Ph: 503-215-2614
Email: CanRsrchStudies@providence.org

Keith S. Lanier
Principal Investigator

Anacortes

Cancer Care Center at Island Hospital

Paul G. Montgomery
Ph: 208-381-3376
Email: mcdonagd@slhs.org

Paul G. Montgomery
Principal Investigator

Bellingham

PeaceHealth Saint Joseph Medical Center

Benjamin Buckner Bridges
Ph: 208-381-3376
Email: mcdonagd@slhs.org

Benjamin Buckner Bridges
Principal Investigator

Centralia

Providence Regional Cancer System-Centralia

Keith S. Lanier
Ph: 503-215-2614
Email: CanRsrchStudies@providence.org

Keith S. Lanier
Principal Investigator

Edmonds

Swedish Medical Center-Edmonds

Keith S. Lanier
Ph: 503-215-2614
Email: CanRsrchStudies@providence.org

Keith S. Lanier
Principal Investigator

Everett

Providence Regional Cancer Partnership

Keith S. Lanier
Ph: 503-215-2614
Email: CanRsrchStudies@providence.org

Keith S. Lanier
Principal Investigator

Issaquah

Swedish Cancer Institute-Issaquah

Keith S. Lanier
Ph: 503-215-2614
Email: CanRsrchStudies@providence.org

Keith S. Lanier
Principal Investigator

Kennewick

Kadlec Clinic Hematology and Oncology

Heidi Joy Gray
Ph: 206-616-8289

Heidi Joy Gray
Principal Investigator

Tri-Cities Cancer Center

Heidi Joy Gray
Ph: 206-616-8289

Heidi Joy Gray
Principal Investigator

Kirkland

EvergreenHealth Medical Center

Heidi Joy Gray
Ph: 206-616-8289

Heidi Joy Gray
Principal Investigator

Lacey

Providence Regional Cancer System-Lacey

Keith S. Lanier
Ph: 503-215-2614
Email: CanRsrchStudies@providence.org

Keith S. Lanier
Principal Investigator

Longview

PeaceHealth Saint John Medical Center

Keith S. Lanier
Ph: 503-215-2614
Email: CanRsrchStudies@providence.org

Keith S. Lanier
Principal Investigator

Mount Vernon

Skagit Valley Hospital

Heidi Joy Gray
Ph: 206-616-8289

Heidi Joy Gray
Principal Investigator

Skagit Valley Hospital Regional Cancer Care Center

Heidi Joy Gray
Ph: 206-616-8289

Heidi Joy Gray
Principal Investigator

Port Angeles

Olympic Medical Center

Heidi Joy Gray
Ph: 206-616-8289

Heidi Joy Gray
Principal Investigator

Seattle

Fred Hutchinson Cancer Research Center

Heidi Joy Gray
Ph: 206-616-8289

Heidi Joy Gray
Principal Investigator

Group Health Cooperative-Seattle

Benjamin Buckner Bridges
Ph: 208-381-3376
Email: mcdonagd@slhs.org

Benjamin Buckner Bridges
Principal Investigator

Northwest Hospital

Heidi Joy Gray
Ph: 206-616-8289

Heidi Joy Gray
Principal Investigator

Pacific Gynecology Specialists

Keith S. Lanier
Ph: 503-215-2614
Email: CanRsrchStudies@providence.org

Keith S. Lanier
Principal Investigator

Seattle Cancer Care Alliance

Heidi Joy Gray
Ph: 206-616-8289

Heidi Joy Gray
Principal Investigator

Swedish Medical Center-Ballard Campus

Keith S. Lanier
Ph: 503-215-2614
Email: CanRsrchStudies@providence.org

Keith S. Lanier
Principal Investigator

Swedish Medical Center-Cherry Hill

Benjamin Buckner Bridges
Ph: 208-381-3376
Email: mcdonagd@slhs.org

Benjamin Buckner Bridges
Principal Investigator

Swedish Medical Center-First Hill

Keith S. Lanier
Ph: 503-215-2614
Email: CanRsrchStudies@providence.org

Keith S. Lanier
Principal Investigator

University of Washington Medical Center

Heidi Joy Gray
Ph: 206-616-8289

Heidi Joy Gray
Principal Investigator

Women's Cancer Center of Seattle

Heidi Joy Gray
Ph: 206-616-8289

Heidi Joy Gray
Principal Investigator

Sequim

Olympic Medical Cancer Care Center

Heidi Joy Gray
Ph: 206-616-8289

Heidi Joy Gray
Principal Investigator

Shelton

Providence Regional Cancer System-Shelton

Keith S. Lanier
Ph: 503-215-2614
Email: CanRsrchStudies@providence.org

Keith S. Lanier
Principal Investigator

Spokane

Cancer Care Northwest - Spokane South

Heidi Joy Gray
Ph: 206-616-8289

Heidi Joy Gray
Principal Investigator

Cancer Care Northwest-North Spokane

Heidi Joy Gray
Ph: 206-616-8289

Heidi Joy Gray
Principal Investigator

Cancer Care Northwest-Valley

Heidi Joy Gray
Ph: 206-616-8289

Heidi Joy Gray
Principal Investigator

Rockwood Cancer Treatment Center-DHEC-Downtown

Benjamin Buckner Bridges
Ph: 208-381-3376
Email: mcdonagd@slhs.org

Benjamin Buckner Bridges
Principal Investigator

Rockwood North Cancer Treatment Center

Benjamin Buckner Bridges
Ph: 208-381-3376
Email: mcdonagd@slhs.org

Benjamin Buckner Bridges
Principal Investigator

Spokane Valley

Rockwood Clinic Cancer Treatment Center-Valley

Benjamin Buckner Bridges
Ph: 208-381-3376
Email: mcdonagd@slhs.org

Benjamin Buckner Bridges
Principal Investigator

Tacoma

Northwest NCI Community Oncology Research Program

John A. Keech
Ph: 253-403-2394

John A. Keech
Principal Investigator

Vancouver

Legacy Salmon Creek Hospital

William E. Winter
Ph: 800-220-4937
Email: cancer@lhs.org

William E. Winter
Principal Investigator

PeaceHealth Southwest Medical Center

Benjamin Buckner Bridges
Ph: 208-381-3376
Email: mcdonagd@slhs.org

Benjamin Buckner Bridges
Principal Investigator

Walla Walla

Providence Saint Mary Regional Cancer Center

Keith S. Lanier
Ph: 503-215-2614
Email: CanRsrchStudies@providence.org

Keith S. Lanier
Principal Investigator

Wenatchee

Wenatchee Valley Hospital and Clinics

Heidi Joy Gray
Ph: 206-616-8289

Heidi Joy Gray
Principal Investigator

Yelm

Providence Regional Cancer System-Yelm

Keith S. Lanier
Ph: 503-215-2614
Email: CanRsrchStudies@providence.org

Keith S. Lanier
Principal Investigator

West Virginia
Wheeling

Wheeling Hospital/Schiffler Cancer Center

Jondavid Pollock
Ph: 304-243-6442

Jondavid Pollock
Principal Investigator

Wisconsin
Green Bay

Saint Vincent Hospital Cancer Center Green Bay

Jonathan Edward Tammela
Ph: 920-433-8889
Email: Christy.Gilchrist@hshs.org

Jonathan Edward Tammela
Principal Investigator

La Crosse

Gundersen Lutheran Medical Center

Kurt Oettel
Ph: 608-775-2385
Email: cancerctr@gundersenhealth.org

Kurt Oettel
Principal Investigator

Milwaukee

Froedtert and the Medical College of Wisconsin

William H. Bradley
Ph: 414-805-4380

William H. Bradley
Principal Investigator

New Richmond

Cancer Center of Western Wisconsin

Rachel E. Lerner
Ph: 952-993-1517
Email: mmcorc@parknicollet.com

Rachel E. Lerner
Principal Investigator

Wyoming
Cody

Billings Clinic-Cody

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Sheridan

Welch Cancer Center

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Japan

Kagoshima City

Kagoshima City Hospital

Toshiaki Nakamura
Ph: 011+81+099+224+2101

Toshiaki Nakamura
Principal Investigator

Kure

Kure National Hospital

Takashi Sawasaki
Ph: (0823) 22-3111

Takashi Sawasaki
Principal Investigator

Niigata City

Niigata University Medical and Dental Hospital

Takayuki Enomoto
Ph: 81-025-223-6161

Takayuki Enomoto
Principal Investigator

Sendai

Tohoku University School of Medicine

Nobuo Yaegashi
Email: med-som@bureau.tohoku.ac.jp

Nobuo Yaegashi
Principal Investigator

Republic of Korea

Incheon

Gachon University Gil Hospital

Kwang-Beom Lee
Ph: -3623

Kwang-Beom Lee
Principal Investigator

Seongnam City

Seoul National University Bundang Hospital

Kidong Kim
Ph: -4882

Kidong Kim
Principal Investigator

Seoul

Kyung Hee University Hospital at Gangdong

Jong-Min Lee
Ph: 82-2-961-0554

Jong-Min Lee
Principal Investigator

Yonsei University Health System-Severance Hospital

Sang-Wun Kim
Email: ihcc@yuhs.ac

Sang-Wun Kim
Principal Investigator

Link to the current ClinicalTrials.gov record.
NLM Identifier NCT01101451

Note: Information about participating sites on pharmaceutical industry trials may be incomplete. Please visit the ClinicalTrials.gov record via the link above for more information about participating sites.