Archive - Insights & Innovations Blog
- Researchers Design a Precise Library for CRISPR-Mediated Genetic Screens
Researchers in the Cancer Target Discovery and Development Network used machine learning to create improved CRISPR libraries for genomic studies. Their new libraries of single guide RNAs can be used to alter gene expression with greater sensitivity and specificity.
- Democratizing Access to CCG Data: Cancer Genomics Cloud Pilots
Big data is essential to cancer research. Yet as we collect more cancer data, we limit the number of researchers who can participate. By enabling access to NCI data and computational resources in the cloud, the cloud pilots contribute to a cancer data ecosystem that enables diverse researchers to advance precision oncology.
- Functional Genomics Study Finds Druggable Target in KRAS-mutant Lung Cancer
A new study by the Cancer Target Discovery and Development Network identified XPO1 as a vulnerability specific to KRAS-mutant lung cancers that responds to available drugs. Paired with genomics-based patient selection, this finding could improve lung cancer care.
- TCGA to Complete its Final Analysis: the PanCanAtlas
TCGA’s data on all 33 cancer types will be integrated into its final analysis, called PanCanAtlas. PanCanAtlas will focus on the themes of cell-of-origin, oncogenic processes, and pathways.
- Diagnosed With Ovarian Cancer, a Researcher Mined TCGA Data to Study Her Own Disease
Faced the bleak prognosis associated with stage IIIC ovarian cancer, Shirley Pepke, Ph.D., used her computational biology background to study her own cancer in comparison to TCGA data. Pepke has now been in remission for a year.