CCG Updates and Insights
Featuring current topics in cancer genomics research and news and updates from CCG.
- From Ignoring Features to Machine Learning Features: Computational Biology Then and Now
Dr. John Weinstein discusses progress in computational biology over the 12-year span of TCGA. The field has expanded greatly, with researchers taking on more complex problems and trying different approaches.
- The Genomic Data Commons Turns 2: Progress in Clinical Tool Development
The Genomic Data Commons (GDC) launched two years ago with the goal to build a collaborative, interactive knowledge system that anyone can use. Dr. Lou Staudt reflects on milestones reached at the GDC’s two year anniversary and challenges ahead in building clinically relevant tools and advancing precision medicine.
- After TCGA: Building Clinical Genomic Resources
The Center for Cancer Genomics (CCG) continues to build genomic resources with a special focus on clinical features and patient outcome. A new wave of cancer characterization projects will generate data relevant for precision medicine and build on the legacy left by The Cancer Genome Atlas, which officially concluded in April 2018.
- Office of Cancer Genomics: Integration of Structural, Functional, and Computational Genomic Data Advances Precision Oncology
A collaborative study conducted by two Office of Cancer Genomics (OCG) initiatives highlights the importance of integrating structural and functional genomics programs to improve cancer therapies, and more specifically, contribute to precision oncology treatments for children.
- Planning a Genomic Characterization Study? Tips for Collecting and Processing Biospecimens
The Biospecimen Core Resource (BCR) collects patient samples and readies them for genomic characterization, analysis, and other downstream steps. The CCG, which has managed the BCR for over a decade for use by The Cancer Genome Atlas and other projects, offers tips for researchers who may be planning their own genomic characterization study.
- How to Navigate the CTD2 Dashboard: Access to Translational Data
The Cancer Target Discovery and Development (CTD2) Dashboard aims to provide easy exploration of data to non-computational scientists. Through an open-access web interface, users can view validated data and results assembled from multiple projects or CTD2 Centers.
- Hope for a Rare Disease Through TCGA: My Perspective as a Caregiver, Patient Advocate, and Physician
The founder of the Melanoma Research Foundation's Community United for Research and Education of Ocular Melanoma (CURE OM) initiative describes her journey from having a loved one diagnosed with a rare disease, to forming a patient advocacy group, to teaming up with The Cancer Genome Atlas in a collaborative research effort.
- CTD2: Bridging Genomics to Therapeutics
The Cancer Target Discovery and Development (CTD2) initiative was established by the National Cancer Institute (NCI) to bridge the gap between cancer genomics and precision oncology and has developed many approaches for identifying therapeutic targets, perturbagens, and biomarkers. CTD2 is currently exploring cancer heterogeneities and developing strategies to overcome treatment resistance.
- A Brief Tour of DAVE: The Genomic Data Commons Analysis Toolkit
The Genomic Data Commons (GDC) gives a brief tour of DAVE: Data Analysis, Visualization, and Exploration Tools. GDC welcomes user questions and feedback to help build an accessible and valuable genomic data resource.