Images of cells showing what our cells do normally, some abnormal proteins cause cancer, and how PROTAC, a small-molecule drug with two binding regions, harnesses the normal process to dispose of cancer-causing proteins. One PROTAC end binds with a cancer-causing protein, while the other end binds with the E3 ligase ("garbage police") and starts tagging, or issuing tickets to, the cancer-causing protein. In this way, the PROTAC molecule takes advantage of a normal process that already exists to direct the cancer-causing protein to the proteasome (the garbage truck) for disposal.