March 2016 - Cancer Currents Blog
- Blocking Calcium Transfer May Selectively Kill Cancer Cells
A new study shows that blocking the transfer of calcium ions (Ca2+) into mitochondria is toxic to cancer cells and impairs growth of tumors in mice, while sparing normal cells.
- New Strategy for Treating Advanced Ovarian Cancer Shows Promise in Mice
The use of a protein fragment to stimulate cells in the tumor microenvironment against cancer shows promise in animal models of metastatic ovarian cancer.
- Crizotinib Approval Expanded for Advanced Lung Cancer
The FDA has approved uses of the targeted therapy crizotinib (Xalkori®) for patients with advanced lung cancer whose tumors have alterations in the ROS1 gene.
- High-Magnification Microscopy Visualizes Tumor Blood Vessels in Real Time
High-powered intravital microscopy reveals that 50 percent of blood vessels in melanoma tumors do not have any blood flow, according to a new study.
- Keeping Pace: How New Data Can Affect Ongoing Clinical Trials
Research results sometimes outrace the design of an ongoing clinical trial and the trial has to be recalibrated to include newer treatments, according to NCI’s Dr. Jo Anne Zujewski.
- Novel Strategy Isolates Immune Cells in the Blood that Recognize Melanoma
NCI scientists have developed a novel strategy for identifying immune cells circulating in the blood that recognize specific proteins on tumor cells, a finding they believe may have potential implications for immune-based therapies.
- HPV Infections Targeted by Vaccine Decrease in U.S.
Infection with human papillomavirus (HPV) types targeted by the quadrivalent HPV vaccine has declined by nearly two-thirds among teenage girls since HPV vaccination was recommended in the United States.
- Fueling Basic Discovery: NCI’s Cooperative Human Tissue Network
Quality biospecimens are a foundational resource for cancer research. One of NCI’s longest running biospecimen programs is the Cooperative Human Tissue Network, a resource mainly for basic discovery and early translational research.
- BRCA Testing Rates High in Young Women with Breast Cancer
Testing for genetic mutations strongly associated with an increased risk of breast cancer has risen dramatically among women younger than age 40 who are diagnosed with the disease, according to a new study.