Research Findings - Cancer Currents Blog
- Trastuzumab Emtansine Improves Survival in Previously Treated Metastatic HER2-Positive Breast Cancer
Two clinical trials show that trastuzumab emtansine (T-DM1) improves survival compared with other standard treatments for patients with HER2-positive metastatic breast cancer that has progressed after treatment with other HER2-targeted drugs.
- Genomic Study Seeks Clues to Help Explain Breast Cancer Disparities
Using one of the largest collections of tumor samples from African Americans with breast cancer, researchers tried to assess the extent to which the molecular characteristics on these tumors might help to explain breast cancer disparities.
- CAR T Cells: Expanding into Multiple Myeloma
Results from two early-phase trials presented at the American Society of Clinical Oncology annual meeting suggest that an immunotherapy using genetically engineered immune cells may be effective in patients with advanced multiple myeloma.
- Biomarker Test Could Reduce Unnecessary Biopsies to Detect Prostate Cancer
Findings from a new study show testing for two biomarkers in urine may help some men avoid an unnecessary biopsy to detect a suspected prostate cancer.
- HPV Vaccination Linked to Decreased Oral HPV Infections
A study of more than 2,600 young adults found that the prevalence of oral infection with four HPV types, including two cancer-causing types, was 88% lower in those who reported receiving at least one dose of an HPV vaccine than in those not vaccinated.
- Study Identifies Genetic Mutations in Tumors From 10,000 Patients with Metastatic Cancer
Researchers at Memorial Sloan Kettering Cancer Center have reported the results of an initiative to characterize the genetic mutations in tumors from more than 10,000 patients with advanced cancer treated at the center.
- Intensive Pre-Stem Cell Transplant Regimen May be Best for Younger Patients with AML, MDS
Results from a large phase III clinical trial suggest that a highly intensive preparatory regimen should be used for younger patients with acute myeloid leukemia or myelodysplastic syndromes preparing to undergo an allogeneic stem cell transplant.
- Counseling Improves Survivorship Plan Implementation for Low-Income Breast Cancer Survivors
In a randomized trial, low-income women who role-played talking with their doctor about their survivorship care plan in a counseling session reported receiving more of their recommended care than women who did not get counseling.
- Collection of Patient-Reported Outcomes Feasible in Cancer Clinical Trials
Cancer patients, even those who are undergoing difficult treatments, are willing to devote time to completing thorough assessments of the side effects they encounter in clinical trials, a new study finds.
- Nanoparticles Create Effective CAR T Cells in Living Mice
Researchers have developed a method to genetically engineer cancer-fighting immune cells in living animals using nanoparticles that carry DNA. The new study shows that the resulting immune cells, known as CAR T cells, eliminated leukemia in mice.
- Patients Who Choose No Intervention for Small Thyroid Cancers Report Lack of Support
Patients who choose not to pursue immediate biopsy or treatment for small, asymptomatic thyroid cancers, or suspected cancers, can experience a lack of support from doctors and loved ones, a new study shows.
- PARP Inhibitors May Be Effective in Brain, Other Cancers with IDH Mutations
Studies presented at the 2017 AACR annual meeting suggest that therapies which take advantage of the mutations in the IDH gene may be more effective than drugs that block it.
- Studies Identify Potential Treatment Strategies for Pediatric DIPG Brain Tumors
Two studies have identified proteins that drive growth of diffuse intrinsic pontine glioma (DIPG) tumor cells. Blocking these targets with investigational drugs slowed tumor growth in animal models.
- Avelumab Becomes First Approved Treatment for Patients with Merkel Cell Carcinoma
The FDA has approved the first drug ever for the rare skin cancer, Merkel cell carcinoma, and updated data show an improved tumor response rate and that patients’ tumors continued to respond for at least a year.
- Blinatumomab Extends Survival for Patients with Advanced ALL
Patients with previously treated acute lymphoblastic leukemia who received blinatumomab, which encourages the immune system to kill cancer cells, lived longer and experienced fewer side effects than patients given standard chemotherapy.
- Targeted Cancer Drug May Also Help Protect Fertility, Study Suggests
Findings from a new study in mice suggest that a class of targeted cancer drugs may have another use in some younger women being treated for cancer: preserving their fertility.
- Colorectal Cancer Incidence Rising in Young Adults: An Interview with Drs. Philip Rosenberg and William Anderson
Drs. Philip Rosenberg and William Anderson of NCI discuss a recent study on which they were coauthors that reported an increase in colorectal cancer incidence among adults under age 50 in the United States.
- Stem-Cell Based Tool May Help Measure Heart Toxicity of Cancer Drugs
Researchers have used adult stem cells to create a tool for ranking how toxic a group of cancer drugs, called tyrosine kinase inhibitors, are to human heart cells. Such a test could potentially identify toxic side effects earlier in the drug development process.
- Researchers Use CRISPR Gene-Editing Tool to Help Turn Immune Cells against Tumors
Using a new tool for editing genomes, known as CRISPR, researchers have genetically engineered immune cells and improved the ability of these cells to kill cancer cells in mice.
- Study Shows Platelets Can Deliver Immunotherapy, Reduce Tumor Regrowth
In experiments in mice, researchers show platelets linked to an immunotherapy drug can help eliminate residual cancer cells that remain after surgery. The engineered platelets may also prevent leftover cancer cells from spreading.
- Lung Cancer Screening Pilot Reveals Challenges, Growing Pains
A demonstration project by the Veterans Health Administration is highlighting some of the complexities and challenges associated with the expansion of lung cancer screening in the United States.
- U.S. Cancer Mortality Rates Falling, But Some Regions Left Behind, Study Finds
A study of nationwide mortality data found that, while cancer deaths in the U.S. dropped between 1980 and 2014, disparities persisted, and in 160 counties cancer mortality rose substantially.
- Potential New Cancer Therapy Could Target Tumors Two Ways
A team of researchers has developed a potential new therapy that may work in two distinct ways to attack tumors, by directly killing cancer cells and immune cells that can suppress the anti-cancer immune response.
- Combination Therapy Improves Survival for Some Men with Recurrent Prostate Cancer
Long-term results from an NCI-sponsored clinical trial suggest that adding androgen deprivation therapy to radiation therapy can improve survival for some men with recurrent prostate cancer.
- Three-Drug Combination Extends Survival for Patients with Multiple Myeloma
A phase III clinical trial demonstrates that adding the drug bortezomib to a commonly used two-drug regimen extends survival in patients with newly diagnosed multiple myeloma.
- New Therapy Benefits Patients with Neuroendocrine Tumors
Results from a clinical trial suggest that 177Lu-Dotatate may soon be a new treatment option for some patients with advanced neuroendocrine tumors.
- Less-Frequent Zoledronic Acid Treatment Effective at Preventing Bone Metastasis Complications
In a clinical trial involving patients with metastatic cancer, administration of zoledronic acid every 12 weeks was as effective at preventing skeletal-related events caused by bone metastases as administration every 4 weeks.
- Genome Study Points to New Subtypes of Esophageal Cancer
A new study by The Cancer Genome Atlas Research Network could help classify esophageal cancers according to their genetic and molecular alterations and identify potential new treatment options.
- Shifts Seen in Tobacco Product Types Purchased in US
The consumption of cigarettes, small cigars, and chewing tobacco has declined over the past 15 years, according to a new study. These declines were partially offset by a rise in consumption of large cigars, pipe tobacco, and snuff.
- The Global Economic Burden of Tobacco: An Interview with Dr. Mark Parascandola
NCI’s Dr. Mark Parascandola answers questions about The Economics of Tobacco and Tobacco Control, the latest in a series of monographs on tobacco use and tobacco control, which was co-written with the World Health Organization.
- Ibrutinib Relieves Chronic Graft-Versus-Host Disease Symptoms
The targeted cancer therapy ibrutinib can effectively treat the symptoms of chronic graft-versus-host disease, a common and serious complication of allogeneic stem cell transplants, findings from a small clinical trial show.
- For Some Breast Cancer Survivors, Drug May Reduce Treatment-Related Joint Pain
Researchers have found that duloxetine (Cymbalta®), a drug most commonly used to treat depression, may also reduce joint pain caused by aromatase inhibitors in some women being treated for early-stage breast cancer.
- New Mouse Model Closely Mimics Most Common Leukemia in Infants
Researchers have created a long-sought-after mouse model for an aggressive form of acute lymphoblastic leukemia that occurs commonly in infants and that the researchers believe can accelerate the development of new therapies for the disease.
- Brain Cancer’s Cholesterol Addiction May Offer New Treatment Strategy
Brain cancer cells are heavily dependent on a constant supply of cholesterol to survive, a new study suggests. And in mice with brain tumors, treatment with a cholesterol-depleting drug slowed tumor growth and improved survival.
- Device Uses Cancer Cells' Mass to Predict Response to Treatment
Scientists have designed a device that measures the mass of single cancer cells to predict how cells respond to drug treatment. The technology could potentially help clinicians determine whether a drug effectively kills cancer cells.
- DINO RNA Molecule Triggers Anticancer Response in Damaged Cells
Studies in cells and mice found that, in cells with damaged DNA, a noncoding RNA called DINO stabilizes the p53 protein and guides the cells into cell death, preventing tumor development.
- Modified Immunotherapy Approach Shows Promise for Leukemia
Researchers have developed an immunotherapy approach that uses immune cells whose natural cancer killing abilities have been enhanced in the lab. In a small clinical trial, the treatment led to remissions in about half of patients with acute myeloid leukemia.
- Metabolomics Study Reveals another Energy Source for Cancer Cells
Researchers have found that cancer cells can use the compound lactate to fuel biochemical reactions and to generate other compounds they need for growth and survival.
- Avelumab Induces Sustained Tumor Responses in Some Patients with Rare Skin Cancer
In a phase II clinical trial, some patients with metastatic Merkel cell carcinoma whose cancer has progressed despite treatment with chemotherapy had durable tumor responses to the immunotherapy drug avelumab.
- Many Cancer Caregivers Report Feeling Unprepared for Caregiving Challenges
Many family members who care for loved ones with cancer do not feel adequately prepared for the caregiving tasks they assume and need help to make informed decisions about end-of-life care, according to a new study.
- Chromosomal Instability Score May Predict Response to Cancer Treatment
A new study suggests that a chromosomal instability score may help guide treatment choices for patients with cancer.
- Approach May Allow for Stem Cell Transplant without Radiation, Chemotherapy
In a recent study, researchers showed that a new approach may provide a safer way to perform stem cell transplants for treating cancer and other diseases.
- Engineered Stem Cells Help Identify Potential New Treatment for Medulloblastoma
Stem cells engineered to mimic medulloblastoma development may help researchers identify potential new treatments, according to a new study.
- Nanoparticle that Mimics Salmonella Counteracts Chemotherapy Resistance
A nanoparticle that mimics Salmonella may help to counteract chemotherapy resistance, according to a new study.
- CA-125 Testing, CT Scans Still Used for Ovarian Cancer Surveillance Despite Lack of Proven Benefit
A new study shows clinicians continue to use CA-125 testing and CT scans to monitor for recurrences although the benefit of these tests has not been proven.
- Adolescents Who Wouldn’t Have Smoked May Be Drawn to E-Cigarettes
The findings from a recent study suggest that adolescents are not just using e-cigarettes as a substitute for conventional cigarettes but that e-cigarettes are attracting new users to tobacco products.
- Nanoparticle Delivers Cancer Drugs to Tumor Blood Vessels
In cancer mouse models, nanoparticles that bind to a protein called P-selectin on tumor blood vessels shrank tumors and extended survival.